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GENE：PPP1R12B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PPP1R12B
FullNmae protein phosphatase 1 regulatory subunit 12B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7619
EnsembleID ENSG00000077157
Uniprot O60237

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PPP1R12B mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPP1R12B immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PPP1R12B GO:0004857,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006937,GO:0007165,GO:0008047,GO:0019208,GO:0019901,GO:0030018,GO:0030018,GO:0031672,GO:0031672

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PPP1R12B hsa:4660 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
PPP1R12B hsa:4660 path:hsa04510 Focal adhesion - Homo sapiens (human)
PPP1R12B hsa:4660 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
PPP1R12B hsa:4660 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
PPP1R12B hsa:4660 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL16 PPP1R12B 12923170 23180781 physical association anti tag coimmunoprecipitation,two hybrid,pull down,surface plasmon resonance InnateDB

Source Target Pmid Interactiontype Methods Database
AR PPP1R12B 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PPP1R12B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PPP1R12B 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 PPP1R12B 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PPP1R12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PPP1R12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PPP1R12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PPP1R12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PPP1R12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PPP1R12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PPP1R12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PPP1R12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PPP1R12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PPP1R12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002152A8 PPP1R12B 23622248 25416803 27292025 mrna cleavage,inhibition clip,clash TarBase
URS00002075FA PPP1R12B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F PPP1R12B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 PPP1R12B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 PPP1R12B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 PPP1R12B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 PPP1R12B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000076995 PPP1R12B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000054DF42 PPP1R12B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001DA458 PPP1R12B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 PPP1R12B 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001C770D PPP1R12B 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000083D87 PPP1R12B 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000AB32B PPP1R12B 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075A760 PPP1R12B 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000007F792 PPP1R12B 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075AB0E PPP1R12B 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000AD002 PPP1R12B 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 PPP1R12B 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ROCK1 PPP1R12B 22135298 phosphorylation N/A PhosphoSite
PPP1CA PPP1R12B 25361965 interaction type N/A PTMCode2
PPP1R12B PPP1CA 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HSPA8 PPP1R12B 25348397 N/A physical interaction ComPPI
PPP2R1A PPP1R12B 25348397 N/A physical interaction ComPPI
PPP1CB PPP1R12B 24234451 25348397 26496610 28330616 association anti tag coimmunoprecipitation,pull down,physical interaction,in vitro,proximity-dependent biotin identification ComPPI,IntAct
SKP1 PPP1R12B 25348397 N/A physical interaction ComPPI
PPP1R12A PPP1R12B 24234451 25348397 28330616 association pull down,proximity-dependent biotin identification ComPPI,IntAct
PRKG1 PPP1R12B 25348397 N/A physical interaction ComPPI
PIK3R3 PPP1R12B 25348397 N/A physical interaction ComPPI
IQGAP1 PPP1R12B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MYO18A PPP1R12B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IL16 PPP1R12B 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
COPS6 PPP1R12B 25348397 N/A physical interaction ComPPI
NUAK1 PPP1R12B 25348397 N/A physical interaction ComPPI
SYNPO PPP1R12B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12B PAN2 25348397 N/A physical interaction ComPPI
PPP1R12B FKBP6 25348397 N/A physical interaction ComPPI
PPP1R12B CD14 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12B MYH9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12B ANLN 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12B MYO19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ROCK1 PPP1R12B 16431080 22937917 27898060 inhibition N/A OmniPath
PPP1R14A PPP1R12B 12495628 27898060 inhibition N/A OmniPath
PPP1R12B MYO18A 186030 27898060 inhibition N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B1987 PPP1R12B 27087310 direct interaction,inhibition N/A NPInter

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