Gene Information gene info

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GENE：ACAN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ACAN
FullNmae aggrecan
LocusType gene with protein product
Status Approved
HGNC_id HGNC:319
EnsembleID ENSG00000157766
Uniprot P16112

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ACAN immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ACAN GO:0001501,GO:0001501,GO:0002052,GO:0005201,GO:0005515,GO:0005540,GO:0005576,GO:0005615,GO:0005796,GO:0006508,GO:0007155,GO:0007417,GO:0010001,GO:0030021,GO:0030246,GO:0043202,GO:0045202,GO:0046872,GO:0062023,GO:0072534

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ACAN SOX9 23180781 24111521 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR ACAN 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA ACAN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ACAN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ACAN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ACAN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ACAN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ACAN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 ACAN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ACAN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ACAN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SHOX ACAN 24421874 trascriptional regulation,stimulation inferred by curator TFlink
SHOX2 ACAN 24421874 trascriptional regulation,stimulation inferred by curator TFlink
SIRT1 ACAN 21337390 trascriptional regulation,stimulation inferred by curator TFlink
SP1 ACAN 12081893 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 ACAN 12081893 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
TNFAIP6 ACAN 25361965 interaction type N/A PTMCode2
ACAN TNFAIP6 25361965 interaction type N/A PTMCode2
ACAN ADAMTS5 25361965 interaction type N/A PTMCode2
ADAMTS5 ACAN 25361965 interaction type N/A PTMCode2
ACAN MMP3 25361965 interaction type N/A PTMCode2
MMP3 ACAN 25361965 interaction type N/A PTMCode2
ACAN MMP14 25361965 interaction type N/A PTMCode2
MMP14 ACAN 25361965 interaction type N/A PTMCode2
ACAN MMP19 25361965 interaction type N/A PTMCode2
MMP19 ACAN 25361965 interaction type N/A PTMCode2
ACAN MMP1 25361965 interaction type N/A PTMCode2
MMP1 ACAN 25361965 interaction type N/A PTMCode2
ACAN FBLN1 25361965 interaction type N/A PTMCode2
FBLN1 ACAN 25361965 interaction type N/A PTMCode2
ACAN CTSB 25361965 interaction type N/A PTMCode2
CTSB ACAN 25361965 interaction type N/A PTMCode2
ACAN ADAMTS4 25361965 interaction type N/A PTMCode2
ADAMTS4 ACAN 25361965 interaction type N/A PTMCode2
MMP2 ACAN 25361965 interaction type N/A PTMCode2
ACAN MMP2 25361965 interaction type N/A PTMCode2
MMP20 ACAN 25361965 interaction type N/A PTMCode2
ACAN MMP20 25361965 interaction type N/A PTMCode2
MMP8 ACAN 25361965 interaction type N/A PTMCode2
ACAN MMP8 25361965 interaction type N/A PTMCode2
LUM ACAN 25361965 interaction type N/A PTMCode2
ACAN LUM 25361965 interaction type N/A PTMCode2
TNR ACAN 25361965 interaction type N/A PTMCode2
ACAN TNR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MMP3 ACAN 14525934 25348397 7998967 N/A experimental interaction detection,protease assay,in vitro ComPPI,HPRD
MMP14 ACAN 11854269 14525934 25348397 27898060 9688535 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
CTSB ACAN 1326552 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PCOLCE ACAN 24117177 24234451 25348397 N/A surface plasmon resonance array ComPPI,IntAct
ADAMTS1 ACAN 12054629 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
FBLN1 ACAN 10400671 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ADAMTS5 ACAN 11854269 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TNR ACAN 11038354 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ADAMTS4 ACAN 10751421 11854269 14525934 14701864 16188468 25348397 N/A experimental interaction detection,protease assay,in vitro ComPPI,HPRD
LUM ACAN 14525934 15505028 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
HAPLN1 ACAN 12888576 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MMP2 ACAN 14525934 25348397 7998967 N/A experimental interaction detection,in vitro ComPPI,HPRD
ACAN MMP19 25348397 N/A in vitro ComPPI
ACAN MMP8 14525934 25348397 7998967 8216228 N/A experimental interaction detection,in vitro ComPPI,HPRD
ACAN TNFAIP6 14525934 25348397 27898060 9654129 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
ACAN FBLN2 11038354 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
ACAN MMP20 10922468 14525934 N/A experimental interaction detection HPRD
ACAN MMP1 14525934 8216228 N/A experimental interaction detection HPRD

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