Gene Information gene info

  1. Home

GENE：AFDN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol AFDN
FullNmae afadin, adherens junction formation factor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7137
EnsembleID ENSG00000130396
Uniprot P55196

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
AFDN mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
AFDN immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
AFDN GO:0005515,GO:0005654,GO:0005829,GO:0005829,GO:0005886,GO:0005911,GO:0005912,GO:0007155,GO:0007165,GO:0007267,GO:0010628,GO:0016607,GO:0022409,GO:0030054,GO:0030336,GO:0031267,GO:0032880,GO:0044291,GO:0044331,GO:0045296,GO:0046930,GO:0046931,GO:0050839,GO:0051015,GO:0061951,GO:0070160,GO:0070830,GO:0090557,GO:2000049

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
AFDN hsa:4301 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
AFDN hsa:4301 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
AFDN hsa:4301 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
AFDN hsa:4301 path:hsa04520 Adherens junction - Homo sapiens (human)
AFDN hsa:4301 path:hsa04530 Tight junction - Homo sapiens (human)
AFDN hsa:4301 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HRAS AFDN 10545207 10922060 23180781 physical association two hybrid InnateDB
AFDN RAP1A 10922060 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
PFN1 AFDN 10922060 23180781 physical association two hybrid InnateDB
AFDN RIT1 10545207 23180781 physical association two hybrid InnateDB
RIT2 AFDN 10545207 23180781 physical association two hybrid InnateDB
EPHB3 AFDN 23331499 9707552 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AFDN MRAS 20005715 interaction type N/A PSP,SignaLink
AFDN RAP2A 20005715 interaction type N/A PSP,SignaLink
AFDN RRAS 20005715 interaction type N/A PSP,SignaLink
AFDN BCR 20005715 interaction type N/A PSP
AFDN SRC 20005715 interaction type N/A PSP,SignaLink
AFDN EPHB2 20005715 interaction type N/A PSP,SignaLink
AFDN EPHB3 20005715 interaction type N/A PSP,SignaLink
AFDN RRAS2 20005715 interaction type N/A PSP
AFDN RAP1A 20005715 interaction type N/A PSP
AFDN PICK1 20005715 interaction type N/A PSP,SignaLink
AFDN BCR 12808105 20005715 20005715 21071413 N/A N/A SignaLink
AFDN RAP1A 10922060 10922060 20005715 20005715 21071413 N/A N/A SignaLink
AFDN RRAS2 11788587 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR AFDN 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 AFDN 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 AFDN 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 AFDN 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA AFDN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF AFDN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 AFDN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS AFDN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A AFDN 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 AFDN 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000134ADC AFDN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000041CB9C AFDN 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
BCR AFDN 22135298 phosphorylation N/A PhosphoSite
CDK2 AFDN 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
NCK2 AFDN 25348397 N/A physical interaction ComPPI
FAM110A AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NECTIN2 AFDN 23750010 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
FAM53C AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
YWHAG AFDN 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,physical interaction ComPPI,IntAct
KEAP1 AFDN 25348397 N/A physical interaction ComPPI
RIN1 AFDN 25348397 N/A physical interaction ComPPI
CBY1 AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
HRAS AFDN 25348397 N/A physical interaction ComPPI
SRC AFDN 17491594 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,filter binding,pull down,imaging technique ComPPI,IntAct
EPHB2 AFDN 24234451 25348397 9707552 physical association two hybrid,physical interaction ComPPI,IntAct
GRB2 AFDN 25348397 N/A physical interaction ComPPI
JUN AFDN 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
SMAD2 AFDN 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CPNE2 AFDN 25348397 N/A physical interaction ComPPI
EPHB6 AFDN 24234451 25348397 9707552 physical association two hybrid,physical interaction ComPPI,IntAct
SORBS1 AFDN 25348397 N/A physical interaction ComPPI
GIGYF1 AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
YWHAB AFDN 15324660 24234451 25348397 physical association coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAZ AFDN 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
PFN1 AFDN 25348397 N/A physical interaction ComPPI
RRAS2 AFDN 25348397 N/A physical interaction ComPPI
MRAS AFDN 10446149 24234451 25348397 physical association two hybrid,coimmunoprecipitation ComPPI,IntAct
NTRK1 AFDN 25348397 N/A physical interaction ComPPI
CDH1 AFDN 25348397 N/A physical interaction ComPPI
MAGI1 AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NECTIN1 AFDN 10225955 24234451 25348397 N/A pull down,physical interaction ComPPI,IntAct
NECTIN3 AFDN 11024295 15811349 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
F11R AFDN 25348397 N/A physical interaction ComPPI
FGF9 AFDN 25348397 N/A physical interaction ComPPI
SORBS2 AFDN 25348397 N/A physical interaction ComPPI
RAB3IP AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAP1A AFDN 25348397 N/A physical interaction ComPPI
YWHAQ AFDN 25348397 N/A physical interaction ComPPI
LMO2 AFDN 12067721 24234451 25348397 27898060 physical association coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct,OmniPath
RIT1 AFDN 10545207 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ARRB2 AFDN 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CYP1A1 AFDN 25348397 N/A physical interaction ComPPI
BCR AFDN 17491594 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
YWHAH AFDN 17979178 24234451 25348397 association tandem affinity purification ComPPI,IntAct
YWHAE AFDN 25348397 N/A physical interaction ComPPI
SSX2IP AFDN 25348397 N/A physical interaction ComPPI
SH3PXD2A AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TBC1D25 AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
VCAM1 AFDN 19738201 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 AFDN 25348397 N/A physical interaction ComPPI
CTNNA1 AFDN 23750010 24234451 25348397 colocalization physical interaction,confocal microscopy ComPPI,IntAct
HIF1AN AFDN 25348397 N/A physical interaction ComPPI
PRKN AFDN 23393160 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NRXN3 AFDN 25348397 N/A physical interaction ComPPI
NRXN2 AFDN 25348397 N/A physical interaction ComPPI
CUL7 AFDN 25348397 N/A physical interaction ComPPI
CDK16 AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NR2C2 AFDN 25348397 N/A physical interaction ComPPI
NOTCH2 AFDN 25348397 N/A physical interaction ComPPI
RAP1GAP AFDN 12590145 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ID2 AFDN 25348397 N/A physical interaction ComPPI
TRIM25 AFDN 25348397 N/A physical interaction ComPPI
EPHB3 AFDN 24234451 25348397 9707552 physical association two hybrid,physical interaction ComPPI,IntAct
KIF13B AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25B AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TESK2 AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EPHA7 AFDN 24234451 25348397 9707552 physical association two hybrid,physical interaction ComPPI,IntAct
SRGAP2 AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ZNF638 AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SIPA1L1 AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ZBTB21 AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EIF4E2 AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
KCTD3 AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NECTIN4 AFDN 15811349 24234451 25348397 physical association two hybrid ComPPI,IntAct
EZR AFDN 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NRAS AFDN 25348397 N/A physical interaction ComPPI
KMT2A AFDN 25348397 N/A physical interaction ComPPI
LATS2 AFDN 25348397 N/A physical interaction ComPPI
USP21 AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
HNRNPA1 AFDN 25348397 N/A physical interaction ComPPI
MTUS2 AFDN 25348397 N/A physical interaction ComPPI
LIMA1 AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DBN1 AFDN 23750010 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,confocal microscopy ComPPI,IntAct
SIRT7 AFDN 25348397 N/A physical interaction ComPPI
KSR1 AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
LRFN1 AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MEN1 AFDN 25348397 N/A physical interaction ComPPI
AGAP1 AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
FN1 AFDN 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
AFDN USP9X 10620020 25348397 27898060 9722616 N/A physical interaction ComPPI,OmniPath
AFDN NRXN1 25348397 N/A physical interaction ComPPI
AFDN NRXN1 25348397 N/A physical interaction ComPPI
AFDN NRXN2 25348397 N/A physical interaction ComPPI
AFDN NRXN3 25348397 N/A physical interaction ComPPI
AFDN JAG1 25348397 N/A physical interaction ComPPI
AFDN TJP1 23750010 24234451 25348397 colocalization physical interaction,confocal microscopy ComPPI,IntAct
AFDN LGR4 25348397 N/A physical interaction ComPPI
AFDN OBSL1 25348397 N/A physical interaction ComPPI
AFDN CCDC8 25348397 N/A physical interaction ComPPI
AFDN NAA38 25348397 N/A physical interaction ComPPI
AFDN NUP35 25348397 N/A physical interaction ComPPI
AFDN CAPZA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AFDN KLHDC3 25348397 N/A physical interaction ComPPI
AFDN MRPS11 25348397 N/A physical interaction ComPPI
AFDN FUOM 25348397 N/A physical interaction ComPPI
AFDN PRICKLE3 25348397 N/A physical interaction ComPPI
AFDN CEPT1 25348397 N/A physical interaction ComPPI
AFDN TMEM184A 25348397 N/A physical interaction ComPPI
AFDN DENND1A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
AFDN DCLK1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
AFDN SRSF12 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
AFDN SYDE1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
AFDN FAM110B 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
AFDN ANKRD34A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
AFDN BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
FGL1 AFDN 25348397 N/A physical interaction ComPPI
HRAS AFDN 10334923 10545207 10922060 27898060 stimulant N/A OmniPath
AFDN RIN1 10545207 27898060 stimulant N/A OmniPath
MAP2K6 AFDN 12808105 27898060 N/A N/A OmniPath
RAP1A AFDN 10224125 10922060 27898060 stimulant N/A OmniPath
AFDN NECTIN3 10744716 11024295 15811349 27898060 N/A N/A OmniPath
AFDN NECTIN2 10225955 10733589 15811349 23750010 27898060 N/A N/A OmniPath
AFDN EPHB6 27898060 9707552 N/A N/A OmniPath
AFDN NECTIN1 10225955 10617658 15811349 27898060 N/A N/A OmniPath
AFDN EPHA7 27898060 9707552 N/A N/A OmniPath
AFDN EPHB3 27898060 9707552 N/A N/A OmniPath
AFDN RIT1 10545207 27898060 stimulant N/A OmniPath

Visualization










  Return