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GENE：LAMA5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LAMA5
FullNmae laminin subunit alpha 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6485
EnsembleID ENSG00000130702
Uniprot O15230

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LAMA5 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LAMA5 GO:0001658,GO:0001738,GO:0001942,GO:0005178,GO:0005201,GO:0005576,GO:0005604,GO:0005604,GO:0005610,GO:0005615,GO:0005634,GO:0007229,GO:0007517,GO:0016331,GO:0016477,GO:0030155,GO:0030324,GO:0030334,GO:0031594,GO:0034446,GO:0036484,GO:0042475,GO:0043083,GO:0043259,GO:0043259,GO:0043260,GO:0045995,GO:0048705,GO:0050678,GO:0060271,GO:0060445,GO:0062023,GO:0070062,GO:0072659,GO:0098965,GO:0098978,GO:0099173

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LAMA5 hsa:3911 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
LAMA5 hsa:3911 path:hsa04510 Focal adhesion - Homo sapiens (human)
LAMA5 hsa:3911 path:hsa04512 ECM-receptor interaction - Homo sapiens (human)
LAMA5 hsa:3911 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
LAMA5 hsa:3911 path:hsa05146 Amoebiasis - Homo sapiens (human)
LAMA5 hsa:3911 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
LAMA5 hsa:3911 path:hsa05200 Pathways in cancer - Homo sapiens (human)
LAMA5 hsa:3911 path:hsa05222 Small cell lung cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GZMB LAMA5 15843372 23180781 protein cleavage protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR LAMA5 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 LAMA5 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 LAMA5 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 LAMA5 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 LAMA5 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 LAMA5 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 LAMA5 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C LAMA5 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 LAMA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LAMA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LAMA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 LAMA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 LAMA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS LAMA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LAMA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF LAMA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 LAMA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 LAMA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 LAMA5 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00003CF1AD LAMA5 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C85C7 LAMA5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000009A9A2 LAMA5 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
LAMA5 LAMC1 25361965 interaction type N/A PTMCode2
LAMC1 LAMA5 25361965 interaction type N/A PTMCode2
LAMA5 LAMC2 25361965 interaction type N/A PTMCode2
LAMC2 LAMA5 25361965 interaction type N/A PTMCode2
LAMA5 BCAM 25361965 interaction type N/A PTMCode2
BCAM LAMA5 25361965 interaction type N/A PTMCode2
LAMA5 LAMB2 25361965 interaction type N/A PTMCode2
LAMB2 LAMA5 25361965 interaction type N/A PTMCode2
LAMA5 DAG1 25361965 interaction type N/A PTMCode2
DAG1 LAMA5 25361965 interaction type N/A PTMCode2
LAMA5 COL7A1 25361965 interaction type N/A PTMCode2
COL7A1 LAMA5 25361965 interaction type N/A PTMCode2
LAMA5 LAMC3 25361965 interaction type N/A PTMCode2
LAMC3 LAMA5 25361965 interaction type N/A PTMCode2
LAMA5 SV2A 25361965 interaction type N/A PTMCode2
SV2A LAMA5 25361965 interaction type N/A PTMCode2
LAMB1 LAMA5 25361965 interaction type N/A PTMCode2
LAMA5 LAMB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CRKL LAMA5 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD2 LAMA5 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
MEP1A LAMA5 10620696 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
UBC LAMA5 25348397 N/A physical interaction ComPPI
CFTR LAMA5 25348397 N/A physical interaction ComPPI
USP4 LAMA5 25348397 N/A physical interaction ComPPI
DAG1 LAMA5 24234451 25348397 association cross-linking study,physical interaction,in vitro ComPPI,IntAct
TFAP2C LAMA5 24234451 24835590 25348397 physical association two hybrid ComPPI,IntAct
LAMA5 SV2A 10617638 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
LAMA5 COL7A1 14525934 25348397 27898060 9245798 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
LAMA5 MYOC 14525934 16289162 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
LAMA5 BTBD10 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
LAMA5 LAMC1 11133776 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
LAMA5 FBLN2 14525934 25348397 9006922 N/A experimental interaction detection,physical interaction ComPPI,HPRD
LAMA5 FBXO6 25348397 N/A physical interaction ComPPI
LAMA5 SUSD4 25348397 N/A physical interaction ComPPI
LAMA5 TMEM25 25348397 N/A physical interaction ComPPI
LAMA5 PTPRK 25348397 N/A physical interaction ComPPI
LAMA5 RNASEH2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LAMA5 CRP 25348397 N/A physical interaction ComPPI
LAMA5 OS9 25348397 N/A physical interaction ComPPI
LAMA5 SCGB2A2 25348397 N/A physical interaction ComPPI
LAMA5 DEFA1 25348397 N/A physical interaction ComPPI
LAMA5 DKK3 25348397 N/A physical interaction ComPPI
LAMA5 ODAPH 25348397 N/A physical interaction ComPPI
LAMA5 INSL5 25348397 N/A physical interaction ComPPI
LAMA5 TRIM25 25348397 N/A physical interaction ComPPI
LAMA5 ATF7IP 14525934 15231748 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
LAMA5 MUC7 16203048 24234451 25348397 physical association two hybrid ComPPI,IntAct
BCAM LAMA5 11133776 12244066 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
NUDCD1 LAMA5 24234451 29021621 association anti tag coimmunoprecipitation IntAct
PLEC LAMA5 24234451 30021884 physical association cross-linking study IntAct
LAMA5 CD151 10842354 15677332 27898060 stimulant N/A OmniPath

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