GENE：PDE4B
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PDE4B |
| FullNmae | phosphodiesterase 4B |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:8781 |
| EnsembleID | ENSG00000184588 |
| Uniprot | Q07343 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PDE4B | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PDE4B | GO:0000930,GO:0001780,GO:0004115,GO:0004115,GO:0004115,GO:0004115,GO:0004115,GO:0005634,GO:0005813,GO:0005829,GO:0005829,GO:0005891,GO:0006198,GO:0007165,GO:0008021,GO:0014069,GO:0030018,GO:0030552,GO:0030593,GO:0032729,GO:0032743,GO:0043015,GO:0043197,GO:0044325,GO:0044325,GO:0046872,GO:0048471,GO:0050852,GO:0050900,GO:0060076,GO:0071222,GO:0071466,GO:0071872,GO:0086004,GO:0140199,GO:1901841,GO:1901898 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PDE4B | hsa:5142 | path:hsa00230 | Purine metabolism - Homo sapiens (human) |
| PDE4B | hsa:5142 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| PDE4B | hsa:5142 | path:hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| PDE4B | hsa:5142 | path:hsa04928 | Parathyroid hormone synthesis, secretion and action - Homo sapiens (human) |
| PDE4B | hsa:5142 | path:hsa05032 | Morphine addiction - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PDE4B | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | PDE4B | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | PDE4B | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | PDE4B | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | PDE4B | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | PDE4B | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | PDE4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PDE4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PDE4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PDE4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PDE4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | PDE4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PDE4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| IGF1R | PDE4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PDE4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | PDE4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | PDE4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | PDE4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | PDE4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000285DCB | PDE4B | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003ABC4 | PDE4B | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007A060 | PDE4B | 25416803 27468165 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00000EED18 | PDE4B | 25416803 27468165 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKACA | PDE4B | 12441002 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| APOA1 | PDE4B | 15174051 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| NTRK1 | PDE4B | 25348397 | N/A | physical interaction | ComPPI |
| PDE4D | PDE4B | 25348397 | N/A | physical interaction | ComPPI |
| XPO1 | PDE4B | 25348397 | N/A | physical interaction | ComPPI |
| PAFAH1B1 | PDE4B | 25348397 | N/A | physical interaction | ComPPI |
| PDE4B | DISC1 | 17043677 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PDE4B | ALB | 15174051 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PDE4B | MAGEA11 | 25348397 | N/A | physical interaction | ComPPI |
| PDE4B | RCBTB2 | 25348397 | N/A | physical interaction | ComPPI |
| PDE4B | MOV10 | 25348397 | N/A | physical interaction | ComPPI |
| PDE4B | NXF1 | 25348397 | N/A | physical interaction | ComPPI |
| PRKACA | PDE4B | 12023945 12441002 27898060 | N/A | N/A | OmniPath |
| PRKCD | PDE4B | 12441002 27898060 | N/A | N/A | OmniPath |