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GENE：PNKP

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PNKP
FullNmae polynucleotide kinase 3'-phosphatase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9154
EnsembleID ENSG00000039650
Uniprot Q96T60

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PNKP parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PNKP immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PNKP GO:0003684,GO:0003690,GO:0003690,GO:0004519,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0006261,GO:0006281,GO:0006281,GO:0006287,GO:0006289,GO:0006303,GO:0006979,GO:0009314,GO:0009314,GO:0010836,GO:0016020,GO:0016310,GO:0017076,GO:0032212,GO:0035861,GO:0046403,GO:0046403,GO:0046403,GO:0046404,GO:0046404,GO:0051103,GO:0051973,GO:1904355,GO:2001034

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PNKP hsa:11284 path:hsa03410 Base excision repair - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
LYL1 PNKP 18160048 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP PNKP 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PNKP 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A PNKP 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 PNKP 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CTCF PNKP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PNKP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PNKP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PNKP 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 PNKP 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
ATM PNKP 22135298 phosphorylation N/A PhosphoSite
XRCC1 PNKP 25361965 interaction type N/A PTMCode2
PNKP XRCC1 25361965 interaction type N/A PTMCode2
PNKP XRCC4 25361965 interaction type N/A PTMCode2
XRCC4 PNKP 25361965 interaction type N/A PTMCode2
PNKP LIG3 25361965 interaction type N/A PTMCode2
LIG3 PNKP 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KRTAP4-12 PNKP 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ZBTB14 PNKP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PNMA5 PNKP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
POLB PNKP 25348397 N/A physical interaction ComPPI
TP53BP1 PNKP 21637298 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
LMNA PNKP 25348397 N/A physical interaction ComPPI
MCM5 PNKP 25348397 N/A physical interaction ComPPI
SP4 PNKP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNIP1 PNKP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HBA1 PNKP 25348397 N/A physical interaction ComPPI
RPRM PNKP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NF2 PNKP 25348397 N/A physical interaction ComPPI
PICK1 PNKP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DDX20 PNKP 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC PNKP 25348397 N/A physical interaction ComPPI
SMAD5 PNKP 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PNKP XRCC1 11163244 14525934 17353931 19155274 21637298 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,isothermal titration calorimetry,pull down,x-ray crystallography,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
PNKP MAGEA11 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PNKP TRIM37 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
PNKP MYOZ1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PNKP LIG3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PNKP MCM3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PNKP NOM1 25348397 N/A physical interaction ComPPI
PNKP XRCC4 14525934 15385968 17353931 21637298 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,isothermal titration calorimetry,pull down,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,HPRD,IntAct
PNKP NOL3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PNKP LAS1L 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PNKP NUP93 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PNKP SLC25A12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PNKP DNAAF5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PNKP ATAD3B 25348397 N/A physical interaction ComPPI
PNKP APP 25348397 N/A physical interaction ComPPI
PNKP MID1 25348397 N/A physical interaction ComPPI
PNKP NASP 25348397 N/A physical interaction ComPPI
PNKP XRCC6 25348397 N/A physical interaction ComPPI
PNKP XRCC5 25348397 N/A physical interaction ComPPI
PNKP SSRP1 25348397 N/A physical interaction ComPPI
PNKP GEMIN4 25348397 N/A physical interaction ComPPI
PNKP CDK11B 25348397 N/A physical interaction ComPPI
PNKP CDK11A 25348397 N/A physical interaction ComPPI
PNKP PARP1 25348397 N/A physical interaction ComPPI
PNKP HNRNPU 25348397 N/A physical interaction ComPPI
PNKP NOLC1 25348397 N/A physical interaction ComPPI
PNKP SUPT16H 25348397 N/A physical interaction ComPPI
PNKP NRDC 25348397 N/A physical interaction ComPPI
PNKP AGTPBP1 25348397 N/A physical interaction ComPPI
PNKP TCOF1 25348397 N/A physical interaction ComPPI
PNKP DCAF1 25348397 N/A physical interaction ComPPI
PNKP UBE2O 25348397 N/A physical interaction ComPPI
PNKP GZMK 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PNKP KDM1A 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PNKP SUV39H1 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PNKP RPA3 25348397 N/A physical interaction ComPPI
PNKP RPA2 25348397 N/A physical interaction ComPPI
PNKP IKZF1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PNKP EED 25348397 N/A physical interaction ComPPI
PNKP CCDC43 25348397 N/A physical interaction ComPPI
PNKP DCPS 25348397 N/A physical interaction ComPPI
PNKP SBDS 25348397 N/A physical interaction ComPPI
PNKP NTRK1 25348397 N/A physical interaction ComPPI
PNKP ATXN3 25348397 25590633 27898060 N/A physical interaction ComPPI,OmniPath
PNKP FOXO3 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
PNKP HBB 25348397 N/A physical interaction ComPPI
PNKP TRIM25 25348397 N/A physical interaction ComPPI
PNKP YWHAZ 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PNKP KLHL12 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP TARBP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP SYNGR3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP DVL3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP CISD2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP CACFD1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP SYP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP MGST2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP CNTROB 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP KANK2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP CARD10 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP FADS6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP GAS8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP THAP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP MSANTD4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP SNX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP MCC 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP COL17A1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP PSTPIP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PNKP TBC1D1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LIG4 PNKP 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RPA1 PNKP 25348397 N/A physical interaction ComPPI
YWHAQ PNKP 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
C18ORF25 PNKP 25348397 N/A physical interaction ComPPI
ZNF639 PNKP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TRIM26 PNKP 25348397 N/A physical interaction ComPPI
ATM PNKP 21637298 21824916 27898060 stimulant N/A OmniPath
XRCC4 PNKP 12032095 15385968 17353931 21637298 26186194 27898060 stimulant N/A OmniPath
XRCC1 PNKP 11163244 15367657 15385968 17353931 19155274 21637298 26496610 27898060 stimulant N/A OmniPath
PRKDC PNKP 21824916 27898060 stimulant N/A OmniPath

Visualization










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