Gene Information gene info

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GENE：PRKG2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRKG2
FullNmae protein kinase cGMP-dependent 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9416
EnsembleID ENSG00000138669
Uniprot Q13237

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRKG2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PRKG2 GO:0004672,GO:0004692,GO:0004692,GO:0005524,GO:0005829,GO:0006468,GO:0007165,GO:0016324,GO:0030553,GO:0031965,GO:0032332,GO:0042802,GO:0046146,GO:0051019,GO:0072659,GO:0106310,GO:1903829,GO:2001226

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRKG2 hsa:5593 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
PRKG2 hsa:5593 path:hsa04540 Gap junction - Homo sapiens (human)
PRKG2 hsa:5593 path:hsa04611 Platelet activation - Homo sapiens (human)
PRKG2 hsa:5593 path:hsa04713 Circadian entrainment - Homo sapiens (human)
PRKG2 hsa:5593 path:hsa04714 Thermogenesis - Homo sapiens (human)
PRKG2 hsa:5593 path:hsa04730 Long-term depression - Homo sapiens (human)
PRKG2 hsa:5593 path:hsa04740 Olfactory transduction - Homo sapiens (human)
PRKG2 hsa:5593 path:hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human)
PRKG2 hsa:5593 path:hsa04924 Renin secretion - Homo sapiens (human)
PRKG2 hsa:5593 path:hsa04970 Salivary secretion - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
YBX1 PRKG2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PRKG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PRKG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PRKG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PRKG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PRKG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PRKG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PRKG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PRKG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PRKG2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 PRKG2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00003003B4 PRKG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000101787 PRKG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000260A3A PRKG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000038718E PRKG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 PRKG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A PRKG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 PRKG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 PRKG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B PRKG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F PRKG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 PRKG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE PRKG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 PRKG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000037B2E0 PRKG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000319E1 PRKG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000496C56 PRKG2 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKG2 NOS3 22135298 phosphorylation N/A PhosphoSite
PRKG2 ERBB2 22135298 phosphorylation N/A PhosphoSite
PRKG2 LASP1 22135298 phosphorylation N/A PhosphoSite
PRKG2 PTS 22135298 phosphorylation N/A PhosphoSite
PRKG2 MET 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PTS PRKG2 10531334 14525934 25348397 7493990 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HSP90AB1 PRKG2 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
UNC119 PRKG2 25348397 N/A physical interaction ComPPI
HSP90AA1 PRKG2 25348397 N/A physical interaction ComPPI
LASP1 PRKG2 25348397 N/A in vitro,in vivo ComPPI
MYLK PRKG2 14525934 25348397 6547441 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PKM PRKG2 25348397 N/A protein kinase assay ComPPI
WDR77 PRKG2 25348397 N/A physical interaction ComPPI
NEDD4 PRKG2 25348397 N/A physical interaction ComPPI
PLCB3 PRKG2 11278298 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKG2 HSP90AA2P 25348397 N/A physical interaction ComPPI
PRKG2 FBXO25 25348397 N/A physical interaction ComPPI
PRKG2 CDKL5 23602568 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
PRKG2 PDE9A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PRKG2 NPHP3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PRKG2 PLCB3 11278298 11325525 16126727 19651622 27898060 N/A N/A OmniPath
PRKG2 NOS3 10671564 11292821 12574113 12644458 15136572 16126727 16428343 16497987 16527820 16527893 16754797 17116756 18622039 21757745 27898060 N/A N/A OmniPath
PRKG2 CREB1 10575022 27898060 stimulant N/A OmniPath
PRKG2 NOLC1 12167624 27898060 N/A N/A OmniPath
PRKG2 HSPB1 19593530 27898060 inhibition N/A OmniPath
PRKG2 NOS1 27898060 7532810 stimulant N/A OmniPath
PRKG2 LASP1 12571245 17287340 18077418 18088087 18212344 18669648 20068231 20166139 27898060 N/A N/A OmniPath
PRKG2 TAGLN 11053353 27898060 N/A N/A OmniPath
PRKG2 PDE5A 15082510 27898060 stimulant N/A OmniPath
PRKG2 CD38 27898060 8663443 stimulant N/A OmniPath
PRKG2 PTS 10531334 20068231 20166139 27898060 7493990 stimulant N/A OmniPath
PRKG2 CTH 25900831 27898060 N/A N/A OmniPath
PRKG2 MTF1 11923282 27898060 N/A N/A OmniPath

Visualization










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