GENE：RYR3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | RYR3 |
| FullNmae | ryanodine receptor 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:10485 |
| EnsembleID | ENSG00000198838 |
| Uniprot | Q15413 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| RYR3 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| RYR3 | GO:0005219,GO:0005219,GO:0005219,GO:0005509,GO:0005516,GO:0005790,GO:0006816,GO:0006874,GO:0006941,GO:0014808,GO:0015278,GO:0016020,GO:0030018,GO:0033017,GO:0033017,GO:0033017,GO:0034704,GO:0042383,GO:0048763,GO:0048763,GO:0051209,GO:0051289,GO:0070588,GO:0071277,GO:0071286,GO:0071313,GO:0071318 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| RYR3 | hsa:6263 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| RYR3 | hsa:6263 | path:hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| RYR3 | hsa:6263 | path:hsa04713 | Circadian entrainment - Homo sapiens (human) |
| RYR3 | hsa:6263 | path:hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| RYR3 | hsa:6263 | path:hsa04970 | Salivary secretion - Homo sapiens (human) |
| RYR3 | hsa:6263 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| RYR3 | hsa:6263 | path:hsa05012 | Parkinson disease - Homo sapiens (human) |
| RYR3 | hsa:6263 | path:hsa05020 | Prion disease - Homo sapiens (human) |
| RYR3 | hsa:6263 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | RYR3 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | RYR3 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | RYR3 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | RYR3 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | RYR3 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | RYR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | RYR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | RYR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | RYR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | RYR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | RYR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | RYR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | RYR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | RYR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | RYR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | RYR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | RYR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | RYR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FKBP1A | RYR3 | 11171121 11598113 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| BMI1 | RYR3 | 25348397 | N/A | physical interaction | ComPPI |
| RYR2 | RYR3 | 12213830 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| CFTR | RYR3 | 25348397 | N/A | physical interaction | ComPPI |
| RYR3 | CUL1 | 25348397 | N/A | physical interaction | ComPPI |
| RYR3 | HNF1A | 20195357 24234451 25348397 | physical association | display technology,physical interaction | ComPPI,IntAct |
| RYR3 | FKBP1B | 25348397 | N/A | physical interaction | ComPPI |
| RTN4 | RYR3 | 24234451 30021884 | physical association | cross-linking study | IntAct |