GENE：SMC5
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SMC5 |
| FullNmae | structural maintenance of chromosomes 5 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:20465 |
| EnsembleID | ENSG00000198887 |
| Uniprot | Q8IY18 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SMC5 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SMC5 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SMC5 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SMC5 | GO:0000217,GO:0000722,GO:0000724,GO:0000724,GO:0000724,GO:0000775,GO:0000781,GO:0000781,GO:0000803,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0006974,GO:0007059,GO:0016605,GO:0016607,GO:0016887,GO:0016925,GO:0019827,GO:0030054,GO:0030261,GO:0030915,GO:0030915,GO:0030915,GO:0032204,GO:0034184,GO:0035061,GO:0035861,GO:0044772,GO:0044828,GO:0051301,GO:0051984,GO:0071459,GO:0090398,GO:0140588 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SMC5 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | SMC5 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| NR1I2 | SMC5 | 19129222 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | SMC5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SMC5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SMC5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | SMC5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SMC5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SMC5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | SMC5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000007F792 | SMC5 | 23446348 23592263 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000046CDA6 | SMC5 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AD002 | SMC5 | 23446348 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C85B2 | SMC5 | 23446348 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000032835F | SMC5 | 23446348 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000020CEC2 | SMC5 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000250A40 | SMC5 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001799A3 | SMC5 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000019D79B | SMC5 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SGTA | SMC5 | 25348397 | N/A | physical interaction | ComPPI |
| TK1 | SMC5 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| TP53BP1 | SMC5 | 24234451 25348397 29656893 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| SMN1 | SMC5 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| YWHAZ | SMC5 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| MDC1 | SMC5 | 24234451 25348397 29656893 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| PJA1 | SMC5 | 25348397 | N/A | physical interaction | ComPPI |
| ASF1B | SMC5 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| RAD50 | SMC5 | 25348397 | N/A | physical interaction | ComPPI |
| BRCA1 | SMC5 | 24234451 25348397 29656893 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| SMC5 | SMC6 | 15601840 18086888 24234451 25348397 26496610 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction | ComPPI,IntAct |
| SMC5 | RABL2A | 25348397 | N/A | physical interaction | ComPPI |
| SMC5 | NSMCE4A | 25348397 | N/A | physical interaction | ComPPI |
| H1-1 | SMC5 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| H1-5 | SMC5 | 24234451 30021884 | physical association | cross-linking study | IntAct |