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GENE：KLC4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol KLC4
FullNmae kinesin light chain 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:21624
EnsembleID ENSG00000137171
Uniprot Q9NSK0

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
KLC4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
KLC4 GO:0005515,GO:0005737,GO:0005871,GO:0005874,GO:0007018,GO:0019894

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
KLC4 hsa:89953 path:hsa04814 Motor proteins - Homo sapiens (human)
KLC4 hsa:89953 path:hsa05010 Alzheimer disease - Homo sapiens (human)
KLC4 hsa:89953 path:hsa05012 Parkinson disease - Homo sapiens (human)
KLC4 hsa:89953 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
KLC4 hsa:89953 path:hsa05016 Huntington disease - Homo sapiens (human)
KLC4 hsa:89953 path:hsa05020 Prion disease - Homo sapiens (human)
KLC4 hsa:89953 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
KLC4 hsa:89953 path:hsa05132 Salmonella infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EZH2 KLC4 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
APP KLC4 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
SMARCA4 KLC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA KLC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF KLC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 KLC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 KLC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 KLC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 KLC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS KLC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A KLC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 KLC4 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000079D48 KLC4 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
KPNA2 KLC4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDE4DIP KLC4 25348397 N/A physical interaction ComPPI
NECAB2 KLC4 25348397 N/A physical interaction ComPPI
CEP43 KLC4 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
KIF5B KLC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COIL KLC4 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
MEOX2 KLC4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
YWHAG KLC4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDR2 KLC4 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
KRT33B KLC4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRT31 KLC4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KATNAL1 KLC4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SERTAD1 KLC4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CBY1 KLC4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EZH2 KLC4 25348397 N/A physical interaction ComPPI
YWHAB KLC4 17353931 24234451 24255178 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAZ KLC4 14525934 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
NTRK1 KLC4 25348397 N/A physical interaction ComPPI
DIAPH1 KLC4 25348397 N/A physical interaction ComPPI
TRIP6 KLC4 25348397 N/A physical interaction ComPPI
COPB2 KLC4 25348397 N/A physical interaction ComPPI
MCM3AP KLC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RUFY1 KLC4 25348397 N/A physical interaction ComPPI
YWHAQ KLC4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ABI3 KLC4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EPB41L2 KLC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KLC1 KLC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAH KLC4 17979178 24234451 25348397 association tandem affinity purification ComPPI,IntAct
YWHAE KLC4 25348397 N/A physical interaction ComPPI
MEF2A KLC4 25348397 N/A physical interaction ComPPI
TRAK2 KLC4 25348397 N/A physical interaction ComPPI
CDK9 KLC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KIF5C KLC4 25348397 N/A physical interaction ComPPI
NUCB1 KLC4 25348397 N/A physical interaction ComPPI
KLC3 KLC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KIF5A KLC4 25348397 N/A physical interaction ComPPI
CLIP2 KLC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KIF2B KLC4 25348397 N/A physical interaction ComPPI
PUF60 KLC4 25348397 N/A physical interaction ComPPI
TADA2A KLC4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TGOLN2 KLC4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NLN KLC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
USHBP1 KLC4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EZR KLC4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
KLC2 KLC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NUP43 KLC4 25348397 N/A physical interaction ComPPI
KRT15 KLC4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KLC4 TCEA2 25348397 N/A physical interaction ComPPI
KLC4 APP 25348397 N/A physical interaction ComPPI
KLC4 COA8 25348397 N/A physical interaction ComPPI
KLC4 CARMIL1 25348397 N/A physical interaction ComPPI
KLC4 KRT13 25348397 N/A physical interaction ComPPI
KLC4 SYNE4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KLC4 CEP57L1 25348397 N/A physical interaction ComPPI
KLC4 KPTN 25348397 N/A physical interaction ComPPI
KLC4 CHRNA9 25348397 N/A physical interaction ComPPI
KLC4 UMPS 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KLC4 KIF14 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KLC4 PARP16 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KLC4 PLXNA3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KLC4 IARS2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KLC4 OSBPL5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KLC4 MYCL 25348397 N/A physical interaction ComPPI
KLC4 COG6 25348397 N/A physical interaction ComPPI
KLC4 KRT34 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KLC4 KRT16 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AZIN1 KLC4 25348397 N/A physical interaction ComPPI
SLC16A9 KLC4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct

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