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GENE：TCL1A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TCL1A
FullNmae TCL1 family AKT coactivator A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11648
EnsembleID ENSG00000100721
Uniprot P56279

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TCL1A immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TCL1A GO:0005515,GO:0005654,GO:0005783,GO:0005829,GO:0008284,GO:0010918,GO:0019901,GO:0031334,GO:0032991,GO:0033138,GO:0033138,GO:0042802,GO:0042802,GO:0043066,GO:0043539,GO:0043539,GO:0071356,GO:0071902

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TCL1A hsa:8115 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TCL1A AKT2 11707444 15169787 23180781 physical association anti tag coimmunoprecipitation,fluorescence polarization spectroscopy,nuclear magnetic resonance,x ray scattering InnateDB
TCL1A AKT1 10716693 11707444 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
TCL1A AKT3 11707444 23180781 physical association anti tag coimmunoprecipitation InnateDB
EP300 TCL1A 19064921 23180781 physical association anti tag coimmunoprecipitation InnateDB
TCL1A JUN 19064921 23180781 physical association anti tag coimmunoprecipitation InnateDB
TCL1A JUNB 19064921 23180781 physical association anti tag coimmunoprecipitation InnateDB
FOS TCL1A 19064921 23180781 physical association anti tag coimmunoprecipitation InnateDB
AKT1 TCL1A 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
PRDM14 TCL1A 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF TCL1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TCL1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TCL1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TCL1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TCL1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 TCL1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
TCL1A AKT3 25361965 interaction type N/A PTMCode2
AKT3 TCL1A 25361965 interaction type N/A PTMCode2
TCL1A AKT1 25361965 interaction type N/A PTMCode2
AKT1 TCL1A 25361965 interaction type N/A PTMCode2
TCL1A AKT2 25361965 interaction type N/A PTMCode2
AKT2 TCL1A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TXLNA TCL1A 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TXLNB TCL1A 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GOLGA2 TCL1A 24234451 25348397 25416956 27107012 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
TCL1A LSM3 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TCL1A TTC33 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TCL1A TP53BP2 25348397 N/A two hybrid,physical interaction ComPPI
TCL1A AKT3 11707444 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TCL1A CALCOCO2 14525934 16189514 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
TCL1A H2AW 14525934 16189514 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
TCL1A AKT1 10983986 12009899 14525934 24234451 25348397 25910212 26871637 29997244 physical association bioluminescence resonance energy transfer,two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
TCL1A AKT2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
TCL1A ATM 22065599 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TCL1A EP300 19064921 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TCL1A FOS 19064921 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TCL1A JUNB 19064921 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TCL1A JUN 19064921 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TCL1A DNMT3A 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TCL1A TCF4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TCL1A TRAF1 24234451 25348397 25416956 27107012 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
TCL1A CADPS 25348397 N/A physical interaction ComPPI
TCL1A WDR47 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TCL1A CEP55 24234451 25348397 25416956 27107012 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
TCL1A PRTFDC1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TCL1A CARD9 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TCL1A FLACC1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TCL1A LNX2 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
TCL1A NTAQ1 24234451 25348397 27107012 physical association two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
TCL1A NIF3L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TCL1A TRMT61A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TCL1A NFKBIA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TCL1A LNX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TCL1A TRAF2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TCL1A TAX1BP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TCL1A INCA1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TCL1A NFKBID 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TCL1A PPP1R13B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TCL1A TEPSIN 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TCL1A TNKS 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TCL1A CCDC13 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TCL1A DDIT4L 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TCL1A TCL1A 24234451 25416956 physical association two hybrid array,two hybrid prey pooling approach IntAct
TLE5 TCL1A 12421830 27898060 stimulant N/A OmniPath
AKT1 TCL1A 10716693 10983986 11707444 12009899 15169787 16189514 25416956 27898060 N/A N/A OmniPath
TCL1A AKT1 10716693 10983986 11707444 12009899 15169787 16189514 25416956 27898060 stimulant N/A OmniPath
FOS TCL1A 19064921 27898060 N/A N/A OmniPath
TCL1A EP300 19064921 27898060 N/A N/A OmniPath
TCL1A AKT3 10983986 11707444 27898060 stimulant N/A OmniPath
AKT2 TCL1A 10983986 11707444 15169787 27898060 N/A N/A OmniPath
TCL1A AKT2 10983986 11707444 15169787 27898060 stimulant N/A OmniPath
TCL1A JUN 19064921 27898060 N/A N/A OmniPath

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