Gene Information gene info

  1. Home

GENE：PLCB2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PLCB2
FullNmae phospholipase C beta 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9055
EnsembleID ENSG00000137841
Uniprot Q00722

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PLCB2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PLCB2 GO:0001580,GO:0004435,GO:0004435,GO:0004435,GO:0004435,GO:0004629,GO:0005509,GO:0005515,GO:0005543,GO:0005829,GO:0006644,GO:0007186,GO:0007200,GO:0007202,GO:0016042,GO:0031680,GO:0031683,GO:0046488,GO:0048015,GO:0051209,GO:0098992

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PLCB2 hsa:5330 path:hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04540 Gap junction - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04611 Platelet activation - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04713 Circadian entrainment - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04720 Long-term potentiation - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04730 Long-term depression - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04742 Taste transduction - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04911 Insulin secretion - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04916 Melanogenesis - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04918 Thyroid hormone synthesis - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04924 Renin secretion - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04927 Cortisol synthesis and secretion - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04929 GnRH secretion - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04934 Cushing syndrome - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04970 Salivary secretion - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04971 Gastric acid secretion - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04972 Pancreatic secretion - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa05016 Huntington disease - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa05131 Shigellosis - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa05142 Chagas disease - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa05143 African trypanosomiasis - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa05146 Amoebiasis - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa05200 Pathways in cancer - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)
PLCB2 hsa:5330 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PLCB2 MAPK14 12054652 23180781 physical association anti tag coimmunoprecipitation InnateDB
PLCB2 MAP2K3 12054652 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
PLCB2 MAP2K6 12054652 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
SLC9A3R1 PLCB2 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
ETS1 PLCB2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 PLCB2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PLCB2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PLCB2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PLCB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PLCB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR PLCB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 PLCB2 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
MAPK14 PLCB2 25361965 interaction type N/A PTMCode2
PLCB2 MAPK14 25361965 interaction type N/A PTMCode2
PLCB2 GNA11 25361965 interaction type N/A PTMCode2
GNA11 PLCB2 25361965 interaction type N/A PTMCode2
PLCB2 RAC1 25361965 interaction type N/A PTMCode2
RAC1 PLCB2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
RAC1 PLCB2 25348397 N/A x-ray crystallography,x-ray crystallography,physical interaction ComPPI
MAPK14 PLCB2 25348397 N/A physical interaction ComPPI
SLC9A3R1 PLCB2 10980202 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SLC9A3R2 PLCB2 25348397 N/A physical interaction ComPPI
GNAQ PLCB2 11753430 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TRPM7 PLCB2 11941371 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
TRPC3 PLCB2 14525934 15623527 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAP2K6 PLCB2 12054652 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SNCA PLCB2 25348397 N/A physical interaction ComPPI
MAP2K3 PLCB2 25348397 N/A two hybrid,physical interaction,in vivo ComPPI
PLCB2 ALK 25348397 N/A physical interaction ComPPI
PLCB2 WDR36 25348397 N/A physical interaction ComPPI
PLCB2 TBXA2R 25348397 N/A physical interaction ComPPI
PLCB2 WDR26 25348397 N/A physical interaction ComPPI
PLCB2 HNRNPCL2 24234451 30021884 physical association cross-linking study IntAct
PLCB2 TRPM7 11941371 22180838 27898060 inhibition N/A OmniPath
GNA11 PLCB2 1333052 27898060 3017978 stimulant N/A OmniPath
MAP2K3 PLCB2 12054652 16189514 27898060 N/A N/A OmniPath
PLCB2 MAP2K3 12054652 16189514 27898060 N/A N/A OmniPath
PLCB2 MAPK14 12054652 27898060 stimulant N/A OmniPath
MAPK14 PLCB2 12054652 27898060 N/A N/A OmniPath
MAP2K6 PLCB2 12054652 16189514 27898060 N/A N/A OmniPath
PLCB2 MAP2K6 12054652 16189514 27898060 N/A N/A OmniPath
GNB1 PLCB2 1465133 27898060 stimulant N/A OmniPath

Visualization










  Return