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GENE：C2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol C2
FullNmae complement C2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1248
EnsembleID ENSG00000166278
Uniprot P06681

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
C2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
C2 GO:0004252,GO:0005515,GO:0005576,GO:0005601,GO:0005615,GO:0006508,GO:0006956,GO:0006956,GO:0006958,GO:0007584,GO:0009617,GO:0032496,GO:0045087,GO:0046872,GO:0070062,GO:0097066,GO:2000427

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
C2 hsa:717 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
C2 hsa:717 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
C2 hsa:717 path:hsa05133 Pertussis - Homo sapiens (human)
C2 hsa:717 path:hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
C2 hsa:717 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
C2 hsa:717 path:hsa05322 Systemic lupus erythematosus - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
C1S C2 11527969 2244876 23180781 cleavage reaction protease assay InnateDB
MASP2 C2 11527969 23180781 cleavage reaction protease assay InnateDB
MASP1 C2 11527969 23180781 cleavage reaction protease assay InnateDB
C2 C4B 11341920 23180781 physical association surface plasmon resonance InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 C2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 C2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 C2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA C2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF C2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 C2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 C2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 C2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 C2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 C2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS C2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A C2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF C2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 C2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00001E0AEA C2 17612493 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
C2 C4B 25361965 interaction type N/A PTMCode2
C4B C2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
C4A C2 25348397 N/A physical interaction ComPPI
CREB3 C2 25348397 N/A two hybrid bait and prey pooling approach ComPPI
EBP C2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STOM C2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CD55 C2 25348397 N/A physical interaction ComPPI
ERGIC3 C2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
C2 SEC11C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
C2 SLC10A1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
C2 FAM209A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
C4B C2 25348397 N/A physical interaction ComPPI
C2 MASP1 10946292 14525934 N/A experimental interaction detection HPRD
PSMA4 C2 14525934 8175701 N/A experimental interaction detection HPRD
C2 C3 14525934 3546307 N/A experimental interaction detection HPRD
C2 C5 12878586 14525934 27898060 8175701 N/A experimental interaction detection HPRD,OmniPath
C2 C1S 11527969 2244876 27898060 N/A N/A OmniPath

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