Gene Information gene info

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GENE：CACNA1S

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CACNA1S
FullNmae calcium voltage-gated channel subunit alpha1 S
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1397
EnsembleID ENSG00000081248
Uniprot Q13698

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CACNA1S immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CACNA1S GO:0001501,GO:0002074,GO:0005245,GO:0005245,GO:0005515,GO:0005516,GO:0005737,GO:0005886,GO:0005891,GO:0005891,GO:0006816,GO:0006936,GO:0006941,GO:0007029,GO:0007520,GO:0007528,GO:0008331,GO:0008331,GO:0016529,GO:0030315,GO:0030315,GO:0031674,GO:0034765,GO:0036094,GO:0043501,GO:0045933,GO:0046872,GO:0048741,GO:0051209,GO:0070588,GO:0071313,GO:0098703,GO:0140677,GO:1990454,GO:1990454

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CACNA1S hsa:779 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04727 GABAergic synapse - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04911 Insulin secretion - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04924 Renin secretion - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04927 Cortisol synthesis and secretion - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04929 GnRH secretion - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04934 Cushing syndrome - Homo sapiens (human)
CACNA1S hsa:779 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
CACNA1S hsa:779 path:hsa05010 Alzheimer disease - Homo sapiens (human)
CACNA1S hsa:779 path:hsa05020 Prion disease - Homo sapiens (human)
CACNA1S hsa:779 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
CACNA1S hsa:779 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
CACNA1S hsa:779 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
CACNA1S hsa:779 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)
CACNA1S hsa:779 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PRDM14 CACNA1S 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPA CACNA1S 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CACNA1S 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CACNA1S 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CACNA1S 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CACNA1S 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 CACNA1S 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
RYR1 CACNA1S 25361965 interaction type N/A PTMCode2
CACNA1S RYR1 25361965 interaction type N/A PTMCode2
CALM3 CACNA1S 25361965 interaction type N/A PTMCode2
CACNA1S CALM3 25361965 interaction type N/A PTMCode2
CALM2 CACNA1S 25361965 interaction type N/A PTMCode2
CACNA1S CALM2 25361965 interaction type N/A PTMCode2
CALM1 CACNA1S 25361965 interaction type N/A PTMCode2
CACNA1S CALM1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CCDC106 CACNA1S 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
YWHAQ CACNA1S 25348397 N/A physical interaction ComPPI
CACNA1S RYR1 12496092 14525934 25348397 9199552 N/A experimental interaction detection,in vivo ComPPI,HPRD
CACNA1S SRI 14525934 25348397 9668070 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CACNA1S RIMS2 14525934 14660679 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CACNA1S PPP2R2A 25348397 N/A physical interaction ComPPI
CACNA1S PDZD3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CACNA1S YWHAZ 20618440 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CACNA1S TNKS2 22153077 24234451 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
CACNA1S CYSRT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct

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