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GENE：CD22

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CD22
FullNmae CD22 molecule
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1643
EnsembleID ENSG00000012124
Uniprot P20273

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CD22 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CD22 GO:0001791,GO:0002638,GO:0005102,GO:0005515,GO:0005737,GO:0005769,GO:0005769,GO:0005886,GO:0007155,GO:0009897,GO:0009986,GO:0016020,GO:0019903,GO:0019903,GO:0019903,GO:0030100,GO:0030246,GO:0030888,GO:0030888,GO:0032809,GO:0033691,GO:0033691,GO:0033691,GO:0042113,GO:0042113,GO:0042609,GO:0042609,GO:0050776,GO:0050849,GO:0050859,GO:0050859,GO:0050859,GO:0050859,GO:0055037,GO:0055037,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CD22 hsa:933 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
CD22 hsa:933 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
CD22 hsa:933 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CD22 PTPRC 15240561 16408005 23180781 7537381 physical association anti tag coimmunoprecipitation,pull down InnateDB
CD19 CD22 16408005 23180781 9120258 physical association anti tag coimmunoprecipitation,pull down InnateDB
CD22 CD22 16408005 23180781 29145629 physical association anti tag coimmunoprecipitation,inferred by curator InnateDB,Reactome
CD22 SH2D1A 19150402 23180781 physical association peptide array,pull down InnateDB
PTPN6 CD22 11551923 23180781 8627166 physical association anti tag coimmunoprecipitation InnateDB
CD22 SYK 23180781 8627166 physical association anti tag coimmunoprecipitation InnateDB
CD22 PLCG1 23180781 8627166 physical association anti tag coimmunoprecipitation InnateDB
PLCG1 CD22 23180781 8627166 physical association anti tag coimmunoprecipitation InnateDB
CD22 GRB2 11551923 23180781 physical association anti tag coimmunoprecipitation InnateDB
CD22 PTPN6 11551923 23180781 23836650 29145629 7618087 9890995 physical association anti tag coimmunoprecipitation,inferred by curator InnateDB,Reactome
CD22 LYN 10228003 23180781 physical association affinity technology InnateDB
IGHM CD22 11994425 29145629 7561031 7706301 8475064 9480991 9547345 9601638 physical association inferred by curator Reactome
CD22 CD79B 11994425 29145629 7561031 7706301 8475064 9480991 9547345 9601638 physical association inferred by curator Reactome
IGKC CD22 11994425 29145629 7561031 7706301 8475064 9480991 9547345 9601638 physical association inferred by curator Reactome
IGHD CD22 11994425 29145629 7561031 7706301 8475064 9480991 9547345 9601638 physical association inferred by curator Reactome
CD79A CD22 11994425 29145629 7561031 7706301 8475064 9480991 9547345 9601638 physical association inferred by curator Reactome
LYN CD22 29145629 9480991 9547345 9601638 enzymatic reaction inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
GATA2 CD22 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 CD22 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CD22 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CD22 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CD22 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CD22 15892171 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 CD22 12855573 trascriptional regulation,stimulation inferred by curator TFlink
JUN CD22 N/A trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 CD22 N/A trascriptional regulation,stimulation inferred by curator TFlink
POU2F2 CD22 N/A trascriptional regulation,stimulation inferred by curator TFlink
SP1 CD22 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A CD22 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 CD22 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000006FDD4 CD22 24169826 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
CD22 ST6GAL1 25361965 interaction type N/A PTMCode2
ST6GAL1 CD22 25361965 interaction type N/A PTMCode2
CD22 AP2M1 25361965 interaction type N/A PTMCode2
AP2M1 CD22 25361965 interaction type N/A PTMCode2
CD22 GRB2 25361965 interaction type N/A PTMCode2
GRB2 CD22 25361965 interaction type N/A PTMCode2
CD22 HP 25361965 interaction type N/A PTMCode2
HP CD22 25361965 interaction type N/A PTMCode2
CD22 ATP2B4 25361965 interaction type N/A PTMCode2
ATP2B4 CD22 25361965 interaction type N/A PTMCode2
CD22 PTPRC 25361965 interaction type N/A PTMCode2
PTPRC CD22 25361965 interaction type N/A PTMCode2
CD22 SYK 25361965 interaction type N/A PTMCode2
SYK CD22 25361965 interaction type N/A PTMCode2
CD22 PTPN6 25361965 interaction type N/A PTMCode2
PTPN6 CD22 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LCP2 CD22 14525934 15668918 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPN6 CD22 14525934 15588985 24234451 25348397 7618087 8627166 9890995 association,physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SYK CD22 14525934 24234451 25348397 8627166 8647200 association,physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
LYN CD22 14525934 24234451 25348397 8647200 association,physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
PIK3R1 CD22 14525934 24234451 25348397 8647200 association coimmunoprecipitation,experimental interaction detection,in vitro ComPPI,HPRD,IntAct
INPP5D CD22 10748054 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SHC1 CD22 10748054 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GRB2 CD22 11551923 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
AP2A1 CD22 25348397 N/A physical interaction ComPPI
PTPRC CD22 10648410 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction,in vivo ComPPI,IntAct
S100A7 CD22 25348397 N/A physical interaction ComPPI
ATP2B4 CD22 14525934 15133509 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
AP2M1 CD22 12646615 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
IGHM CD22 25348397 N/A in vivo ComPPI
HP CD22 11967116 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CD19 CD22 14525934 16408005 25348397 27898060 9120258 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
CD22 PLCG1 14525934 24234451 25348397 8627166 association,physical association coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
CD22 CPA4 25348397 N/A physical interaction ComPPI
ST6GAL1 CD22 14525934 25348397 8702538 N/A experimental interaction detection,in vitro ComPPI,HPRD
LYN CD22 10228003 10748054 27898060 8647200 stimulant N/A OmniPath
CD22 PTPN6 10228003 11356834 11551923 15588985 27898060 7618087 8627166 9890995 stimulant N/A OmniPath
PTPN6 CD22 10228003 11356834 11551923 15588985 27898060 7618087 8627166 9890995 N/A N/A OmniPath
GRB2 CD22 10748054 11551923 27898060 N/A N/A OmniPath
GSK3B CD22 16393971 27898060 N/A N/A OmniPath

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