GENE：CD3G
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CD3G |
| FullNmae | CD3 gamma subunit of T-cell receptor complex |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1675 |
| EnsembleID | ENSG00000160654 |
| Uniprot | P09693 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CD3G | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CD3G | GO:0002250,GO:0004888,GO:0004888,GO:0004888,GO:0005515,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0007163,GO:0007166,GO:0007166,GO:0007166,GO:0009897,GO:0015031,GO:0030159,GO:0030669,GO:0042105,GO:0042105,GO:0042105,GO:0042105,GO:0042106,GO:0042110,GO:0042608,GO:0042802,GO:0045059,GO:0046629,GO:0046631,GO:0050852,GO:0065003,GO:0070228 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CD3G | hsa:917 | path:hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| CD3G | hsa:917 | path:hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| CD3G | hsa:917 | path:hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| CD3G | hsa:917 | path:hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| CD3G | hsa:917 | path:hsa05142 | Chagas disease - Homo sapiens (human) |
| CD3G | hsa:917 | path:hsa05162 | Measles - Homo sapiens (human) |
| CD3G | hsa:917 | path:hsa05166 | Human T-cell leukemia virus 1 infection - Homo sapiens (human) |
| CD3G | hsa:917 | path:hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| CD3G | hsa:917 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
| CD3G | hsa:917 | path:hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CD3G | SYK | 11493682 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| ZAP70 | CD3G | 11493682 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CD3G | CD3E | 15084594 23109003 | chemical activation reaction | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | CD3G | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CEBPA | CD3G | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CD3G | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFATC1 | CD3G | 15879122 16219537 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFATC2 | CD3G | 15879122 16219537 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | CD3G | 16219537 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00006DE17B | CD3G | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F2EB0 | CD3G | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C4DB5 | CD3G | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000007F792 | CD3G | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AD002 | CD3G | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000075C4B1 | CD3G | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000355E82 | CD3G | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKCA | CD3G | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LAT | CD3G | 25348397 | N/A | two hybrid | ComPPI |
| CD3E | CD3G | 14525934 20890284 2138083 24234451 25348397 | association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| CD3D | CD3G | 14525934 25348397 9485181 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| CD3G | NR3C1 | 25348397 | N/A | physical interaction | ComPPI |
| CD3G | FYN | 25348397 | N/A | physical interaction | ComPPI |
| CD3G | MAL | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CD3G | TMEM54 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CD3G | TMEM203 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CD3G | EMP1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CD3G | TMEM262 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| PDGFRB | CD3G | 27898060 3112151 | N/A | N/A | OmniPath |