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GENE：FAH

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FAH
FullNmae fumarylacetoacetate hydrolase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3579
EnsembleID ENSG00000103876
Uniprot P16930

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FAH immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FAH GO:0004334,GO:0005515,GO:0005829,GO:0006527,GO:0006559,GO:0006559,GO:0006572,GO:0006629,GO:0046872,GO:0070062,GO:1902000

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FAH hsa:2184 path:hsa00350 Tyrosine metabolism - Homo sapiens (human)
FAH hsa:2184 path:hsa01100 Metabolic pathways - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FAH EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 FAH 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 FAH 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC FAH 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 FAH 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 FAH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FAH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FAH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FAH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FAH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FAH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FAH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FAH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FAH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 FAH 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 FAH 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EED18 FAH 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000DDD35 FAH 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
PLEKHF2 FAH 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRTAP5-9 FAH 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP10-8 FAH 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LDHA FAH 25348397 N/A physical interaction ComPPI
SERTAD1 FAH 25348397 N/A physical interaction ComPPI
PGM1 FAH 25348397 N/A physical interaction ComPPI
EGFR FAH 20029029 24234451 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
SORD FAH 25348397 N/A physical interaction ComPPI
GOT2 FAH 25348397 N/A physical interaction ComPPI
ADAMTSL4 FAH 25348397 N/A physical interaction ComPPI
ABAT FAH 25348397 N/A physical interaction ComPPI
TCF4 FAH 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct

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