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GENE：KPNA3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol KPNA3
FullNmae karyopherin subunit alpha 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6396
EnsembleID ENSG00000102753
Uniprot O00505

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
KPNA3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
KPNA3 GO:0005515,GO:0005634,GO:0005643,GO:0005654,GO:0005654,GO:0005654,GO:0005829,GO:0005829,GO:0006606,GO:0006607,GO:0008139,GO:0042564,GO:0043657,GO:0046718,GO:0061608,GO:0065003,GO:0075732

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
KPNA3 hsa:3839 path:hsa03013 Nucleocytoplasmic transport - Homo sapiens (human)
KPNA3 hsa:3839 path:hsa05132 Salmonella infection - Homo sapiens (human)
KPNA3 hsa:3839 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
KPNA3 IRF9 15175343 23180781 physical association gst pull down InnateDB
WAS KPNA3 23180781 24872192 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 KPNA3 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 KPNA3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 KPNA3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 KPNA3 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 KPNA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA KPNA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF KPNA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 KPNA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 KPNA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 KPNA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A KPNA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF KPNA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC KPNA3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000BD1DE KPNA3 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001938D9 KPNA3 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 KPNA3 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 KPNA3 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000285DCB KPNA3 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000015B295 KPNA3 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000016FD1B KPNA3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 KPNA3 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00003BD367 KPNA3 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS0000081E1F KPNA3 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000008931A KPNA3 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000034979B KPNA3 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS0000171CD1 KPNA3 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000041CB9C KPNA3 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00000F0F49 KPNA3 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000007D64A KPNA3 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000040EE1D KPNA3 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00000F6E49 KPNA3 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00004407DC KPNA3 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
KPNA3 KPNB1 25361965 interaction type N/A PTMCode2
KPNB1 KPNA3 25361965 interaction type N/A PTMCode2
KPNA3 HNRNPC 25361965 interaction type N/A PTMCode2
HNRNPC KPNA3 25361965 interaction type N/A PTMCode2
KPNA3 RCC1 25361965 interaction type N/A PTMCode2
RCC1 KPNA3 25361965 interaction type N/A PTMCode2
NFKB1 KPNA3 25361965 interaction type N/A PTMCode2
KPNA3 NFKB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KPNA2 KPNA3 25348397 N/A physical interaction ComPPI
FAM90A1 KPNA3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FAM50B KPNA3 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MAPK9 KPNA3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HNRNPC KPNA3 14525934 16189514 19447967 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
HEXIM2 KPNA3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ZCCHC12 KPNA3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KPNA3 FTL 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KPNA3 TEX37 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KPNA3 APOL6 25348397 N/A two hybrid,physical interaction ComPPI
KPNA3 DDX21 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KPNA3 RCC1 10744690 14525934 25348397 26186194 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
KPNA3 TGM2 10100610 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
KPNA3 COIL 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
KPNA3 KPNB1 10523667 14525934 24234451 25348397 26496610 27898060 9435235 association anti tag coimmunoprecipitation,experimental interaction detection,surface plasmon resonance,physical interaction,in vitro ComPPI,HPRD,IntAct,OmniPath
KPNA3 NFKB1 14525934 14743216 25348397 N/A experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD
KPNA3 CDKN1B 14525934 15057270 24234451 25348397 association,physical association experimental interaction detection,pull down,biochemical,in vitro ComPPI,HPRD,IntAct
KPNA3 ARRB2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA3 ARRB1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA3 USP42 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA3 MEPCE 25348397 N/A physical interaction ComPPI
KPNA3 SIRT1 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
KPNA3 CUL3 25348397 N/A physical interaction ComPPI
KPNA3 ZNF131 25348397 N/A physical interaction ComPPI
KPNA3 BARD1 25348397 N/A physical interaction ComPPI
KPNA3 TP53BP1 25348397 N/A physical interaction ComPPI
KPNA3 CBX5 20562864 21888893 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
KPNA3 NACC1 25348397 N/A physical interaction ComPPI
KPNA3 HDAC1 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA3 MYOD1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
KPNA3 NFE2L2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
KPNA3 EPHA2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
KPNA3 ERCC3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KPNA3 GATA6 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
KPNA3 GTF2H1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KPNA3 MCM4 25348397 N/A physical interaction ComPPI
KPNA3 KPNA6 25348397 N/A physical interaction ComPPI
KPNA3 MCM6 25348397 N/A physical interaction ComPPI
KPNA3 MMS19 25348397 N/A physical interaction ComPPI
KPNA3 HSF1 24234451 25036637 25348397 27173435 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
KPNA3 MVP 25348397 N/A physical interaction ComPPI
KPNA3 MTA1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KPNA3 ZBTB24 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KPNA3 TSSC4 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KPNA3 NUP50 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KPNA3 MAT2B 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KPNA3 ZCCHC10 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KPNA3 RPRD1A 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KPNA3 SLC5A11 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KPNA3 POLDIP3 25348397 N/A physical interaction ComPPI
KPNA3 APEX1 25348397 N/A physical interaction ComPPI
KPNA3 IER2 25348397 N/A physical interaction ComPPI
KPNA3 HSPB1 24234451 25277244 25348397 physical association reverse ras recruitment system,physical interaction ComPPI,IntAct
KPNA3 ACTR1A 25348397 N/A physical interaction ComPPI
KPNA3 CANX 25348397 N/A physical interaction ComPPI
KPNA3 CLGN 25348397 N/A physical interaction ComPPI
KPNA3 COPB1 25348397 N/A physical interaction ComPPI
KPNA3 GNL1 25348397 N/A physical interaction ComPPI
KPNA3 HSP90B1 25348397 N/A physical interaction ComPPI
KPNA3 IPO8 25348397 N/A physical interaction ComPPI
KPNA3 IPO9 25348397 N/A physical interaction ComPPI
KPNA3 NRDC 25348397 N/A physical interaction ComPPI
KPNA3 KPNA4 25348397 N/A physical interaction ComPPI
KPNA3 TMCO1 25348397 N/A physical interaction ComPPI
KPNA3 NTRK1 25348397 N/A physical interaction ComPPI
KPNA3 KIF22 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA3 NCBP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA3 NUP153 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA3 NCBP2 24234451 25348397 26382858 26496610 association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
KPNA3 LCOR 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA3 KMT2E 25348397 N/A physical interaction ComPPI
KPNA3 UBXN7 25348397 N/A physical interaction ComPPI
KPNA3 RBBP4 25348397 N/A physical interaction ComPPI
KPNA3 FAM204A 25348397 N/A physical interaction ComPPI
KPNA3 CTDSPL2 25348397 N/A physical interaction ComPPI
KPNA3 PPM1D 25348397 N/A physical interaction ComPPI
KPNA3 MECP2 25348397 N/A physical interaction ComPPI
KPNA3 B2M 25348397 N/A physical interaction ComPPI
KPNA3 LMNA 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
KPNA3 GTF2IRD1 25348397 N/A physical interaction ComPPI
KPNA3 BRCA1 25348397 N/A physical interaction ComPPI
KPNA3 AICDA 19412186 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
KPNA3 RELA 25348397 N/A tandem affinity purification ComPPI
KPNA3 MDM4 16511560 24234451 25348397 physical association pull down ComPPI,IntAct
KPNA3 HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
KPNA3 GRM1 19084525 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
KPNA3 SLX4 19596235 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
KPNA3 MRTFA 20818336 24234451 25348397 physical association peptide array ComPPI,IntAct
KPNA3 CBX1 21888893 24234451 25348397 association tandem affinity purification ComPPI,IntAct
KPNA3 HTT 17500595 24234451 25348397 physical association two hybrid ComPPI,IntAct
KPNA3 SF1 24234451 25348397 26420826 physical association two hybrid fragment pooling approach ComPPI,IntAct
KPNA3 ZNF76 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KPNA3 FAM214B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KPNA3 BAHD1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KPNA3 POLR3C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KPNA3 NMNAT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KPNA3 ZNF764 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KPNA3 UVSSA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KPNA3 TNIP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KPNA3 CCDC102B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KPNA3 KAT5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KPNA3 RAD52 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KPNA3 NPM1 20701745 24234451 25348397 N/A pull down ComPPI,IntAct
KPNA3 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
KPNA3 LARP7 18281698 24234451 25348397 association tandem affinity purification ComPPI,IntAct
NCBP3 KPNA3 24234451 26382858 association pull down IntAct
KPNA3 NOTCH1 20454918 27898060 stimulant N/A OmniPath
IRF9 KPNA3 15175343 27898060 N/A N/A OmniPath
WAS KPNA3 24872192 27898060 N/A N/A OmniPath

Visualization










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