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GENE：METTL1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol METTL1
FullNmae methyltransferase 1, tRNA methylguanosine
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7030
EnsembleID ENSG00000037897
Uniprot Q9UBP6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
METTL1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
METTL1 GO:0000049,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006400,GO:0008176,GO:0008176,GO:0030488,GO:0036265,GO:0036416,GO:0043527,GO:0106004,GO:0106143

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AKT1 METTL1 15861136 23180781 phosphorylation reaction in-gel kinase assay InnateDB
WDR4 METTL1 15861136 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 METTL1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 METTL1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HIF1A METTL1 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
MYC METTL1 12747840 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
EGR1 METTL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000037E170 METTL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001EE123 METTL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004F24A9 METTL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000A9FB9 METTL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000054A671 METTL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075ABF4 METTL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000519450 METTL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000E7139 METTL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000192A75 METTL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF METTL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001A6D0C METTL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 METTL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 METTL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000246356 METTL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 METTL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000204177 METTL1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
RPS6KA1 METTL1 22135298 phosphorylation N/A PhosphoSite
AKT1 METTL1 22135298 phosphorylation N/A PhosphoSite
METTL1 WDR4 25361965 interaction type N/A PTMCode2
WDR4 METTL1 25361965 interaction type N/A PTMCode2
METTL1 MRTO4 25361965 interaction type N/A PTMCode2
MRTO4 METTL1 25361965 interaction type N/A PTMCode2
NSUN2 METTL1 25361965 interaction type N/A PTMCode2
METTL1 NSUN2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TSNAX METTL1 25348397 N/A physical interaction ComPPI
TPD52L2 METTL1 25348397 N/A physical interaction ComPPI
DR1 METTL1 25348397 N/A physical interaction ComPPI
PRKDC METTL1 25348397 N/A physical interaction ComPPI
GTF2I METTL1 25348397 N/A physical interaction ComPPI
TOM1L1 METTL1 25348397 N/A physical interaction ComPPI
PRDX1 METTL1 25348397 N/A physical interaction ComPPI
CACYBP METTL1 25348397 N/A physical interaction ComPPI
RPS6KA1 METTL1 14525934 15861136 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PDLIM5 METTL1 25348397 N/A physical interaction ComPPI
IPO11 METTL1 25348397 N/A physical interaction ComPPI
TP53RK METTL1 25348397 N/A physical interaction ComPPI
ACTR3 METTL1 25348397 N/A physical interaction ComPPI
ARPC1B METTL1 25348397 N/A physical interaction ComPPI
NUCB1 METTL1 25348397 N/A physical interaction ComPPI
SNU13 METTL1 25348397 N/A physical interaction ComPPI
AKT1 METTL1 14525934 15861136 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
METTL1 WDR4 14525934 15861136 16189514 24234451 25348397 25416956 26751069 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vivo,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
METTL1 METTL18 25348397 N/A physical interaction ComPPI
METTL1 AARS1 25348397 N/A physical interaction ComPPI
METTL1 ARPC2 25348397 N/A physical interaction ComPPI
METTL1 ARPC4 25348397 N/A physical interaction ComPPI
METTL1 ARPC5 25348397 N/A physical interaction ComPPI
METTL1 DNAAF5 25348397 N/A physical interaction ComPPI
METTL1 KIFBP 25348397 N/A physical interaction ComPPI
METTL1 ACTR2 25348397 N/A physical interaction ComPPI
METTL1 NPLOC4 25348397 N/A physical interaction ComPPI
METTL1 TPRKB 25348397 N/A physical interaction ComPPI
METTL1 NIF3L1 25348397 N/A physical interaction ComPPI
METTL1 PCLAF 25348397 N/A physical interaction ComPPI
METTL1 PRDX2 25348397 N/A physical interaction ComPPI
METTL1 UBE3A 25348397 N/A physical interaction ComPPI
METTL1 APEX1 25348397 N/A physical interaction ComPPI
METTL1 C15ORF40 25348397 N/A physical interaction ComPPI
METTL1 PPA2 25348397 N/A physical interaction ComPPI
METTL1 TRMT61A 25348397 N/A physical interaction ComPPI
CTPS2 METTL1 25348397 N/A physical interaction ComPPI
RPS6KA1 METTL1 15861136 25233213 27898060 inhibition N/A OmniPath
AKT1 METTL1 15861136 27898060 3627513 inhibition N/A OmniPath
METTL1 AKT1 15861136 27898060 N/A N/A OmniPath
RPS6KA3 METTL1 15861136 27898060 N/A N/A OmniPath

Visualization










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