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GENE：PDE6D

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PDE6D
FullNmae phosphodiesterase 6D
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8788
EnsembleID ENSG00000156973
Uniprot O43924

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PDE6D immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PDE6D GO:0005095,GO:0005515,GO:0005737,GO:0005829,GO:0005829,GO:0005856,GO:0005929,GO:0007601,GO:0030659,GO:0031267,GO:0031410,GO:0050896

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PDE6D hsa:5147 path:hsa00230 Purine metabolism - Homo sapiens (human)
PDE6D hsa:5147 path:hsa01100 Metabolic pathways - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HRAS PDE6D 11980706 23180781 physical association two hybrid InnateDB
RND1 PDE6D 11980706 23180781 physical association two hybrid InnateDB
PDE6D RAP1A 11980706 23180781 physical association two hybrid InnateDB
ARL2 PDE6D 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PDE6D 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA PDE6D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PDE6D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PDE6D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PDE6D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC PDE6D N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000027464B PDE6D 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000047A8F PDE6D 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000214763 PDE6D 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F PDE6D 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001A6D0C PDE6D 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 PDE6D 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 PDE6D 22100165 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ARL16 PDE6D 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CDC42 PDE6D 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PDE6D RHOB 11786539 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
PDE6D RHOA 11786539 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
PDE6D RAP1A 11786539 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
PDE6D RAP2B 11786539 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
PDE6D HRAS 11980706 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
PDE6D GRK1 14525934 16473576 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
PDE6D GRK7 14525934 16473576 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
PDE6D RAB8A 14525934 16473576 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PDE6D RHEB 11980706 14525934 23698361 24234451 25348397 physical association two hybrid,experimental interaction detection,fluorescent resonance energy transfer,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
PDE6D RAB13 14525934 24234451 25348397 27898060 9712853 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
PDE6D ARL3 10518933 11980706 14525934 16169070 18588884 24234451 25348397 26455799 27898060 association,physical association two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo,tandem affinity purification,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct,OmniPath
PDE6D ARL2 11980706 14525934 16189514 18588884 21516116 24234451 25348397 25416956 27107012 physical association two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,pull down,physical interaction,mammalian protein protein interaction trap,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
PDE6D RND1 11786539 11980706 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
PDE6D RPGR 14525934 23559067 24234451 25348397 27898060 9990021 physical association two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,molecular sieving,pull down,x-ray crystallography,physical interaction,in vitro,inference by socio-affinity scoring,two hybrid ComPPI,HPRD,IntAct,OmniPath
PDE6D CETN3 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PDE6D RAD23A 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PDE6D ARL15 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PDE6D PTGIR 14525934 16527812 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
PDE6D RAB18 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PDE6D FAM219A 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PDE6D RASA1 11786539 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
PDE6D GNAI1 11980706 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PDE6D CUL1 25348397 N/A physical interaction ComPPI
PDE6D COPS5 25348397 N/A physical interaction ComPPI
PDE6D TALDO1 25348397 N/A physical interaction ComPPI
PDE6D DNAJC11 25348397 N/A physical interaction ComPPI
PDE6D C6ORF141 25348397 N/A physical interaction ComPPI
PDE6D INPP5E 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
PDE6D RAB28 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
PDE6D KRAS 23698361 25348397 27898060 N/A physical interaction,amplified luminescent proximity homogeneous assay ComPPI,OmniPath
PDE6D OTP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PDE6D HRAS 11786539 11980706 27898060 N/A N/A OmniPath
RAP1A PDE6D 11786539 11980706 27898060 N/A N/A OmniPath

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