GENE：PLCG2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PLCG2 |
| FullNmae | phospholipase C gamma 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9066 |
| EnsembleID | ENSG00000197943 |
| Uniprot | P16885 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PLCG2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PLCG2 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PLCG2 | GO:0001775,GO:0001784,GO:0001878,GO:0002092,GO:0002223,GO:0002223,GO:0002224,GO:0002281,GO:0002316,GO:0002732,GO:0004435,GO:0004435,GO:0004435,GO:0004435,GO:0004629,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005886,GO:0006661,GO:0009395,GO:0010628,GO:0010628,GO:0010634,GO:0012501,GO:0016055,GO:0019216,GO:0019722,GO:0019722,GO:0019901,GO:0030168,GO:0030183,GO:0031663,GO:0032481,GO:0032587,GO:0032733,GO:0032735,GO:0032743,GO:0032747,GO:0032755,GO:0032760,GO:0032959,GO:0035556,GO:0035556,GO:0035556,GO:0038095,GO:0043069,GO:0043122,GO:0043410,GO:0045121,GO:0048015,GO:0048471,GO:0048678,GO:0050731,GO:0050850,GO:0050852,GO:0050853,GO:0050853,GO:0050853,GO:0050853,GO:0051091,GO:0051092,GO:0051209,GO:0051209,GO:0060100,GO:0060907,GO:0061760,GO:0070062,GO:0070884,GO:0071277,GO:0071396,GO:0097110,GO:0097708,GO:0140031,GO:0150078,GO:1900227,GO:1902808,GO:1903428,GO:1903721,GO:1990782,GO:1990858 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PLCG2 | hsa:5336 | path:hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa01521 | EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04611 | Platelet activation - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04613 | Neutrophil extracellular trap formation - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa04935 | Growth hormone synthesis, secretion and action - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa05110 | Vibrio cholerae infection - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa05131 | Shigellosis - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa05171 | Coronavirus disease - COVID-19 - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa05214 | Glioma - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| PLCG2 | hsa:5336 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PLCG2 | WAS | 10590061 23180781 | physical association | gst pull down | InnateDB |
| PLCG2 | JAK1 | 14978237 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PLCG2 | JAK2 | 14978237 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PLCG2 | SYK | 10026222 10469124 12573241 14656219 15161916 15184383 16449524 19592646 21659545 22041900 23180781 24243840 29145629 7517665 7518558 8629002 8630736 8657103 8702662 8986718 8995445 | enzymatic reaction,physical association | anti tag coimmunoprecipitation,gst pull down,inferred by curator | InnateDB,Reactome |
| PLCG2 | LYN | 10469124 10981967 23180781 | phosphorylation reaction,physical association | anti tag coimmunoprecipitation,gst pull down,affinity technology,in-gel kinase assay | InnateDB |
| PLCG2 | GRB2 | 10469124 23180781 | physical association | gst pull down | InnateDB |
| PLCG2 | CTTN | 10469124 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PLCG2 | FCER1G | 10469124 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PLCG2 | PLCG2 | 10469124 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PLCG2 | MAPT | 18467332 23180781 | physical association | pull down | InnateDB |
| PLCG2 | IRS2 | 15644415 29145629 8034732 | physical association | inferred by curator | Reactome |
| LYN | PLCG2 | 15644415 29145629 8034732 | physical association | inferred by curator | Reactome |
| IGKC | PLCG2 | 15161916 29145629 7517665 8657103 | physical association | inferred by curator | Reactome |
| PLCG2 | BTK | 12573241 15184383 15365099 21659545 24243840 29145629 7518558 8629002 8630736 8986718 | enzymatic reaction,physical association | inferred by curator | Reactome |
| VAV1 | PLCG2 | 10395673 11007481 11278486 11340169 11804587 12573241 12670394 17540168 24243840 29145629 7518558 8629002 8630736 8673706 8986718 9099726 | physical association | inferred by curator | Reactome |
| PLCG2 | SOS1 | 10026222 10811803 11390650 12471105 19592646 20484116 24243840 29145629 8702662 8995445 | physical association | inferred by curator | Reactome |
| PLCG2 | DAPP1 | 10770799 29145629 | physical association | inferred by curator | Reactome |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BLNK | PLCG2 | 20005715 | interaction type | N/A | PSP |
| CD19 | PLCG2 | 20005715 | interaction type | N/A | PSP |
| GAB1 | PLCG2 | 20005715 | interaction type | N/A | PSP,SignaLink |
| GRB2 | PLCG2 | 20005715 | interaction type | N/A | PSP |
| LAT | PLCG2 | 20005715 | interaction type | N/A | PSP |
| LAT2 | PLCG2 | 20005715 | interaction type | N/A | PSP |
| LCP2 | PLCG2 | 20005715 | interaction type | N/A | PSP,SignaLink |
| PIK3R1 | PLCG2 | 20005715 | interaction type | N/A | PSP,SignaLink |
| SH3BP2 | PLCG2 | 20005715 | interaction type | N/A | PSP |
| SHC1 | PLCG2 | 10623845 20005715 21071413 | interaction type | N/A | PSP,SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PLCG2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | PLCG2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | PLCG2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | PLCG2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| PRDM14 | PLCG2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | PLCG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PLCG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PLCG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | PLCG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PLCG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PLCG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PLCG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PLCG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PLCG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | PLCG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | PLCG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | PLCG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | PLCG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | PLCG2 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000048BA36 | PLCG2 | 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C85C7 | PLCG2 | 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F859B | PLCG2 | 20371350 22012620 23446348 24398324 24906430 25416803 26701625 27292025 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000023F008 | PLCG2 | 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005F9738 | PLCG2 | 20371350 22012620 23446348 24398324 24906430 25416803 26701625 27292025 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000148B91 | PLCG2 | 20371350 22012620 23446348 24398324 24906430 25416803 26701625 27292025 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C770D | PLCG2 | 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000060AABB | PLCG2 | 20371350 22012620 23446348 24398324 24906430 25416803 26701625 27292025 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000048D44E | PLCG2 | 20371350 24398324 24906430 25416803 26701625 27292025 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00003D8730 | PLCG2 | 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000122ED0 | PLCG2 | 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032EF64 | PLCG2 | 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237CBD | PLCG2 | 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029979D | PLCG2 | 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000B1C9 | PLCG2 | 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000A07C1 | PLCG2 | 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000031E12 | PLCG2 | 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000324096 | PLCG2 | 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000022AAA | PLCG2 | 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000435A77 | PLCG2 | 20371350 24398324 24906430 25416803 26701625 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000075B0F6 | PLCG2 | 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C5969 | PLCG2 | 20371350 22012620 24398324 24906430 25416803 26701625 27292025 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00005CC20C | PLCG2 | 20371350 22012620 23446348 24398324 24906430 25416803 26701625 27292025 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000075AB16 | PLCG2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000605E00 | PLCG2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SYK | PLCG2 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| SRC | PLCG2 | 22135298 | phosphorylation | N/A | PhosphoSite |
| LCK | PLCG2 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| FYN | PLCG2 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| BTK | PLCG2 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| RAC2 | PLCG2 | 25361965 | interaction type | N/A | PTMCode2 |
| PLCG2 | RAC2 | 25361965 | interaction type | N/A | PTMCode2 |
| PLCG2 | FYN | 25361965 | interaction type | N/A | PTMCode2 |
| PLCG2 | SYK | 25361965 | interaction type | N/A | PTMCode2 |
| PLCG2 | HCK | 25361965 | interaction type | N/A | PTMCode2 |
| HCK | PLCG2 | 25361965 | interaction type | N/A | PTMCode2 |
| PLCG2 | TEC | 25361965 | interaction type | N/A | PTMCode2 |
| TEC | PLCG2 | 25361965 | interaction type | N/A | PTMCode2 |
| PLCG2 | SHC1 | 25361965 | interaction type | N/A | PTMCode2 |
| SHC1 | PLCG2 | 25361965 | interaction type | N/A | PTMCode2 |
| PLCG2 | LCK | 25361965 | interaction type | N/A | PTMCode2 |
| KDR | PLCG2 | 25361965 | interaction type | N/A | PTMCode2 |
| PLCG2 | KDR | 25361965 | interaction type | N/A | PTMCode2 |
| LCP2 | PLCG2 | 25361965 | interaction type | N/A | PTMCode2 |
| PLCG2 | LCP2 | 25361965 | interaction type | N/A | PTMCode2 |
| EPOR | PLCG2 | 25361965 | interaction type | N/A | PTMCode2 |
| PLCG2 | EPOR | 25361965 | interaction type | N/A | PTMCode2 |
| GAB1 | PLCG2 | 25361965 | interaction type | N/A | PTMCode2 |
| PLCG2 | GAB1 | 25361965 | interaction type | N/A | PTMCode2 |
| EGFR | PLCG2 | 25361965 | interaction type | N/A | PTMCode2 |
| PLCG2 | EGFR | 25361965 | interaction type | N/A | PTMCode2 |
| ERBB2 | PLCG2 | 25361965 | interaction type | N/A | PTMCode2 |
| PLCG2 | ERBB2 | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3R1 | PLCG2 | 25361965 | interaction type | N/A | PTMCode2 |
| PLCG2 | PIK3R1 | 25361965 | interaction type | N/A | PTMCode2 |
| BLK | PLCG2 | 25361965 | interaction type | N/A | PTMCode2 |
| PLCG2 | BLK | 25361965 | interaction type | N/A | PTMCode2 |
| GAB2 | PLCG2 | 25361965 | interaction type | N/A | PTMCode2 |
| PLCG2 | GAB2 | 25361965 | interaction type | N/A | PTMCode2 |
| PLCG2 | BTK | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LCP2 | PLCG2 | 25348397 | N/A | in vitro | ComPPI |
| RALBP1 | PLCG2 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| LAT | PLCG2 | 24234451 24642916 25348397 | N/A | surface plasmon resonance,physical interaction,in vitro,surface plasmon resonance array | ComPPI,IntAct |
| NPM1 | PLCG2 | 25348397 | N/A | in vivo | ComPPI |
| PTPN6 | PLCG2 | 25348397 | N/A | physical interaction | ComPPI |
| ZNF512B | PLCG2 | 15231748 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| ERBB2 | PLCG2 | 16273093 24234451 25241761 25348397 | physical association | protein array,physical interaction,proximity ligation assay | ComPPI,IntAct |
| VAV1 | PLCG2 | 25348397 | N/A | physical interaction | ComPPI |
| BTK | PLCG2 | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| SYK | PLCG2 | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| TEC | PLCG2 | 25348397 | N/A | in vitro | ComPPI |
| SH3BP2 | PLCG2 | 11390470 24234451 25348397 | association | pull down,in vivo | ComPPI,IntAct |
| CBLB | PLCG2 | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| BLNK | PLCG2 | 21822214 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction,in vivo | ComPPI,IntAct |
| KIT | PLCG2 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
| LYN | PLCG2 | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| PIK3R1 | PLCG2 | 17474147 24234451 25241761 25348397 | physical association | peptide array,physical interaction,proximity ligation assay | ComPPI,IntAct |
| PTPN11 | PLCG2 | 25348397 | N/A | physical interaction | ComPPI |
| PRKCA | PLCG2 | 25348397 | N/A | physical interaction | ComPPI |
| LCK | PLCG2 | 25348397 | N/A | in vitro | ComPPI |
| FLT1 | PLCG2 | 25348397 | N/A | two hybrid,in vitro | ComPPI |
| KDR | PLCG2 | 25348397 | N/A | in vivo | ComPPI |
| PLCG2 | SHC1 | 10623845 12135708 25348397 27898060 | N/A | physical interaction,in vivo | ComPPI,OmniPath |
| PLCG2 | KHDRBS1 | 25348397 | N/A | in vitro,in vivo | ComPPI |
| PLCG2 | PRKD1 | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| PLCG2 | GAB2 | 25348397 | N/A | physical interaction,in vitro,in vivo | ComPPI |
| PLCG2 | LAT2 | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| PLCG2 | JAK1 | 25348397 | N/A | in vivo | ComPPI |
| PLCG2 | JAK2 | 25348397 | N/A | in vivo | ComPPI |
| PLCG2 | CD19 | 25348397 | N/A | in vivo | ComPPI |
| PLCG2 | EPOR | 15644415 24234451 25348397 | physical association | two hybrid,mammalian protein protein interaction trap,in vivo | ComPPI,IntAct |
| PLCG2 | ITK | 25348397 | N/A | in vitro | ComPPI |
| PLCG2 | DAPP1 | 25348397 | N/A | in vitro,in vivo | ComPPI |
| PLCG2 | LIME1 | 25348397 | N/A | in vivo | ComPPI |
| PLCG2 | FCER1G | 25348397 | N/A | in vivo | ComPPI |
| PLCG2 | FYN | 25348397 | N/A | physical interaction,in vitro,in vivo | ComPPI |
| PLCG2 | HCK | 25348397 | N/A | in vitro | ComPPI |
| PLCG2 | PLXNB1 | 25348397 | N/A | physical interaction | ComPPI |
| PLCG2 | IRS1 | 25348397 | N/A | physical interaction | ComPPI |
| PLCG2 | PLD1 | 25348397 | N/A | physical interaction | ComPPI |
| PLCG2 | EGFR | 16273093 24234451 24658140 25241761 25348397 | physical association | protein array,ubiquitin reconstruction,physical interaction,luminescence based mammalian interactome mapping,proximity ligation assay | ComPPI,IntAct |
| PLCG2 | LHX8 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array,validated two hybrid | ComPPI,IntAct |
| PLCG2 | PTTG1 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array,validated two hybrid | ComPPI,IntAct |
| PLCG2 | PTTG2 | 25348397 | N/A | physical interaction | ComPPI |
| PLCG2 | TP53 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array,validated two hybrid | ComPPI,IntAct |
| PLCG2 | ELK1 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array,validated two hybrid | ComPPI,IntAct |
| PLCG2 | EPYC | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array,validated two hybrid | ComPPI,IntAct |
| PLCG2 | HSPD1 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array,validated two hybrid | ComPPI,IntAct |
| PLCG2 | ASB9 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| PLCG2 | RTL10 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| PLCG2 | SETD9 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| PLCG2 | KCTD17 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| PLCG2 | PSMD3 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping | ComPPI,IntAct |
| PLCG2 | FSBP | 25348397 | N/A | physical interaction | ComPPI |
| PLCG2 | RAD54B | 25348397 | N/A | physical interaction | ComPPI |
| PLCG2 | ZKSCAN7 | 25348397 | N/A | physical interaction | ComPPI |
| PLCG2 | PLCG1 | 24234451 25241761 25348397 | physical association | physical interaction,proximity ligation assay | ComPPI,IntAct |
| PLCG2 | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
| PLCG2 | GRB2 | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| PLCG2 | AR | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
| PLCG2 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
| PLCG2 | CD244 | 24234451 24642916 25348397 | N/A | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| PLCG2 | SH2D1B | 24234451 24642916 25348397 | association | pull down,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| BLK | PLCG2 | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| GAB1 | PLCG2 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy,in vivo | ComPPI,IntAct |
| ISL1 | PLCG2 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| TWIST2 | PLCG2 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| MED28 | PLCG2 | 16964398 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| ESD | PLCG2 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| GABPB2 | PLCG2 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| SRC | PLCG2 | 11606584 27898060 | stimulant | N/A | OmniPath |
| LCK | PLCG2 | 11606584 12181444 15144186 15184383 16497976 19901323 27898060 7682059 | stimulant | N/A | OmniPath |
| LYN | PLCG2 | 10469124 10981967 12181444 15144186 16497976 19901323 27898060 7682059 8395016 | N/A | N/A | OmniPath |
| PLCG2 | LYN | 10469124 10981967 12181444 15144186 27898060 7682059 8395016 | N/A | N/A | OmniPath |
| FYN | PLCG2 | 12181444 15144186 16497976 19901323 27898060 7682059 8395016 | stimulant | N/A | OmniPath |
| HCK | PLCG2 | 12181444 15144186 16497976 19901323 27898060 7682059 | N/A | N/A | OmniPath |
| PLCG2 | TRPC3 | 12970180 27898060 | stimulant | N/A | OmniPath |
| PLCG2 | GRB2 | 10469124 17474147 27898060 | N/A | N/A | OmniPath |
| JAK1 | PLCG2 | 14978237 27898060 | N/A | N/A | OmniPath |
| BTK | PLCG2 | 10981967 11507089 11606584 11971963 12093870 12181444 12780340 14656219 15184383 16497976 17239630 17290227 19690332 19901323 27898060 7682059 | stimulant | N/A | OmniPath |
| JAK2 | PLCG2 | 14978237 27898060 | N/A | N/A | OmniPath |
| PLCG2 | WAS | 10590061 27898060 | N/A | N/A | OmniPath |