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GENE：PPM1F

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PPM1F
FullNmae protein phosphatase, Mg2+/Mn2+ dependent 1F
LocusType gene with protein product
Status Approved
HGNC_id HGNC:19388
EnsembleID ENSG00000100034
Uniprot P49593

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PPM1F immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPM1F autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPM1F apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPM1F apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PPM1F GO:0004722,GO:0004722,GO:0005515,GO:0005634,GO:0005829,GO:0005829,GO:0006469,GO:0006469,GO:0006470,GO:0008138,GO:0010628,GO:0010634,GO:0010811,GO:0017018,GO:0030335,GO:0032880,GO:0032991,GO:0033137,GO:0033192,GO:0035970,GO:0043280,GO:0043280,GO:0044387,GO:0045892,GO:0045927,GO:0046872,GO:0048471,GO:0050921,GO:0051224,GO:0051496,GO:0051496,GO:0051496,GO:0051894,GO:0070262,GO:0071466,GO:0097193,GO:2000048

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR PPM1F 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PPM1F 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PPM1F 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PPM1F 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PPM1F 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PPM1F 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PPM1F 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PPM1F 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PPM1F 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PPM1F 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PPM1F 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PPM1F 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000005481D PPM1F 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 PPM1F 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000036AFF1 PPM1F 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000331800 PPM1F 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002CEB74 PPM1F 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002F0130 PPM1F 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F PPM1F 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002FF522 PPM1F 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075D814 PPM1F 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075CC78 PPM1F 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005F9738 PPM1F 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000AF45F PPM1F 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003E226A PPM1F 19536157 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075AB14 PPM1F 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005C1F22 PPM1F 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047E28E PPM1F 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000006B702 PPM1F 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000017CCCB PPM1F 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000034979B PPM1F 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000006A1CB PPM1F 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D PPM1F 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D PPM1F 25416803 26498692 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PPM1F CAMK2A 25361965 interaction type N/A PTMCode2
CAMK2A PPM1F 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PRKAA2 PPM1F 20801214 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ROR2 PPM1F 25348397 N/A physical interaction ComPPI
TOMM22 PPM1F 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ERBB2 PPM1F 25348397 N/A physical interaction ComPPI
PAK1 PPM1F 25348397 N/A in vivo ComPPI
ERBB4 PPM1F 25348397 N/A physical interaction ComPPI
PSMA3 PPM1F 25348397 N/A physical interaction ComPPI
TRIO PPM1F 25348397 N/A physical interaction ComPPI
PRKAA1 PPM1F 20801214 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NTRK1 PPM1F 25348397 N/A physical interaction ComPPI
DIAPH1 PPM1F 18230650 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,filter binding ComPPI,IntAct,OmniPath
EGFR PPM1F 25348397 N/A physical interaction ComPPI
ARHGEF7 PPM1F 11864573 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MARS1 PPM1F 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
INSR PPM1F 25348397 N/A physical interaction ComPPI
ELAVL1 PPM1F 25348397 N/A physical interaction ComPPI
CDC25B PPM1F 25348397 N/A physical interaction ComPPI
LMTK2 PPM1F 25348397 N/A physical interaction ComPPI
FEM1B PPM1F 11559703 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PPM1F FEM1A 11559703 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PPM1F FAM161A 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PPM1F FBXO6 25348397 N/A physical interaction ComPPI
PPM1F CAMK2A 11559703 24234451 25348397 dephosphorylation reaction physical interaction,phosphatase assay ComPPI,IntAct
PPM1F CEP164 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PPM1F MUC20 25348397 N/A physical interaction ComPPI
PPM1F AATK 25348397 N/A physical interaction ComPPI
PPM1F ERBB3 25348397 N/A physical interaction ComPPI
PPM1F ROR1 25348397 N/A physical interaction ComPPI
PPM1F PTK7 25348397 N/A physical interaction ComPPI
IGF1R PPM1F 25348397 N/A physical interaction ComPPI
PPM1F PPM1F 11559703 14525934 N/A experimental interaction detection HPRD
PPM1F PAK1 11864573 20016286 27898060 inhibition N/A OmniPath
PPM1F PAK2 20016286 27898060 inhibition N/A OmniPath
PPM1F CAMK2A 10814834 11559703 15140879 27898060 inhibition N/A OmniPath
PPM1F CAMK1 10814834 15680915 27898060 9442023 inhibition N/A OmniPath
PPM1F CAMK4 10814834 15680915 27898060 inhibition N/A OmniPath

Visualization










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