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GENE：PRPS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRPS1
FullNmae phosphoribosyl pyrophosphate synthetase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9462
EnsembleID ENSG00000147224
Uniprot P60891

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRPS1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PRPS1 GO:0000287,GO:0002189,GO:0004749,GO:0004749,GO:0004749,GO:0005515,GO:0005524,GO:0005524,GO:0005737,GO:0005829,GO:0006015,GO:0006015,GO:0006144,GO:0006164,GO:0006164,GO:0006221,GO:0007399,GO:0009156,GO:0016301,GO:0016310,GO:0034418,GO:0042802,GO:0042803,GO:0046101

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRPS1 hsa:5631 path:hsa00030 Pentose phosphate pathway - Homo sapiens (human)
PRPS1 hsa:5631 path:hsa00230 Purine metabolism - Homo sapiens (human)
PRPS1 hsa:5631 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PRPS1 hsa:5631 path:hsa01200 Carbon metabolism - Homo sapiens (human)
PRPS1 hsa:5631 path:hsa01230 Biosynthesis of amino acids - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
YWHAE PRPS1 20462248 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR PRPS1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PRPS1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PRPS1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 PRPS1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 PRPS1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PRPS1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PRPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PRPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PRPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PRPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PRPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PRPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PRPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PRPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PRPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR PRPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 PRPS1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00005651EE PRPS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000041CB9C PRPS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000032835F PRPS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C85B2 PRPS1 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 PRPS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B989F PRPS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000007F792 PRPS1 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000AD002 PRPS1 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000039A052 PRPS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075C4B1 PRPS1 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000045147B PRPS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001A7F58 PRPS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00006DE17B PRPS1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000027352D PRPS1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003D4175 PRPS1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000A2C49 PRPS1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000078918 PRPS1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000040828B PRPS1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002B7450 PRPS1 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
RBKS PRPS1 25361965 interaction type N/A PTMCode2
PRPS1 RBKS 25361965 interaction type N/A PTMCode2
PRPS1 PRPS1 25361965 interaction type N/A PTMCode2
PRPS1 PRPSAP1 25361965 interaction type N/A PTMCode2
PRPSAP1 PRPS1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NDUFB9 PRPS1 25348397 N/A physical interaction ComPPI
BRMS1 PRPS1 25348397 N/A physical interaction ComPPI
KEAP1 PRPS1 25348397 N/A physical interaction ComPPI
JUN PRPS1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
UBB PRPS1 25348397 N/A physical interaction ComPPI
DLD PRPS1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NTRK1 PRPS1 25348397 N/A physical interaction ComPPI
TUBA4A PRPS1 25348397 N/A physical interaction ComPPI
GORASP2 PRPS1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
ELF2 PRPS1 25348397 N/A physical interaction ComPPI
YWHAE PRPS1 25348397 N/A physical interaction ComPPI
SPG21 PRPS1 14525934 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
GTF2F1 PRPS1 25348397 N/A physical interaction ComPPI
TP53RK PRPS1 25348397 N/A physical interaction ComPPI
ATXN3 PRPS1 25348397 N/A physical interaction ComPPI
NARS1 PRPS1 25348397 N/A physical interaction ComPPI
PRKN PRPS1 25348397 N/A physical interaction ComPPI
PRPSAP1 PRPS1 14525934 16189514 24234451 25348397 25416956 25910212 9366267 physical association experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
PRPS1 SUMO4 14525934 16236267 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRPS1 PRPS2 24234451 25348397 25416956 26496610 association,physical association anti tag coimmunoprecipitation,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PRPS1 TWF1 25348397 N/A physical interaction ComPPI
PRPS1 SMURF1 25348397 N/A physical interaction ComPPI
PRPS1 FBXO6 25348397 N/A physical interaction ComPPI
PRPS1 PFDN1 25348397 N/A physical interaction ComPPI
PRPS1 DNAJA4 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRPS1 RPAP3 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRPS1 EML4 25348397 N/A physical interaction ComPPI
PRPS1 PRPSAP2 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRPS1 NMT2 25348397 N/A physical interaction ComPPI
PRPS1 PRPS1L1 25348397 N/A physical interaction ComPPI
PRPS1 CDK5RAP2 25348397 N/A physical interaction ComPPI
PRPS1 NFRKB 25348397 N/A physical interaction ComPPI
PRPS1 ELP3 25348397 N/A physical interaction ComPPI
PRPS1 PLS1 25348397 N/A physical interaction ComPPI
PRPS1 BOD1L1 25348397 N/A physical interaction ComPPI
PRPS1 SETD1A 25348397 N/A physical interaction ComPPI
PRPS1 RPS4Y1 25348397 N/A physical interaction ComPPI
PRPS1 CXXC1 25348397 N/A physical interaction ComPPI
PRPS1 FARSA 25348397 N/A physical interaction ComPPI
PRPS1 NMD3 25348397 N/A physical interaction ComPPI
PRPS1 PPAT 25348397 N/A physical interaction ComPPI
PRPS1 SBDS 25348397 N/A physical interaction ComPPI
PRPS1 POC5 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PRPS1 STIL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PRPS1 TCTN1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PRPS1 PRPF19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRPS1 FBXO31 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRPS1 KLHL13 25348397 N/A physical interaction ComPPI
PRPS1 TOP1MT 25348397 N/A physical interaction ComPPI
PRPS1 ATOH1 25348397 N/A physical interaction ComPPI
PRPS1 CRBN 25348397 N/A physical interaction ComPPI
PRPS1 DUSP28 25348397 N/A physical interaction ComPPI
PRPS1 KHK 25348397 N/A anti tag coimmunoprecipitation,pull down,phosphorylation reaction,physical interaction,protein kinase assay ComPPI
PRPS1 NFKB1 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
PRPS1 PRPS1 14525934 16189514 24234451 25416956 25910212 physical association two hybrid array,two hybrid pooling approach,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid,two hybrid HPRD,IntAct
NUDCD1 PRPS1 24234451 29021621 association anti tag coimmunoprecipitation IntAct

Visualization










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