GENE：TLN2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TLN2 |
| FullNmae | talin 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:15447 |
| EnsembleID | ENSG00000171914 |
| Uniprot | Q9Y4G6 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TLN2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TLN2 | GO:0001726,GO:0003779,GO:0005178,GO:0005198,GO:0005200,GO:0005515,GO:0005737,GO:0005886,GO:0005925,GO:0005925,GO:0007010,GO:0007043,GO:0007155,GO:0015629,GO:0045202,GO:0051015,GO:0098609 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TLN2 | hsa:83660 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| TLN2 | hsa:83660 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
| TLN2 | hsa:83660 | path:hsa04611 | Platelet activation - Homo sapiens (human) |
| TLN2 | hsa:83660 | path:hsa05131 | Shigellosis - Homo sapiens (human) |
| TLN2 | hsa:83660 | path:hsa05166 | Human T-cell leukemia virus 1 infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | TLN2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | TLN2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | TLN2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | TLN2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | TLN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | TLN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TLN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | TLN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | TLN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | TLN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | TLN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | TLN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | TLN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | TLN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | TLN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | TLN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | TLN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000028BB8 | TLN2 | 22310291 22330136 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS0000028BB8 | TLN2 | 22310291 22330136 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS000018E6CD | TLN2 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005CCD18 | TLN2 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000486E0B | TLN2 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C85B2 | TLN2 | 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ITGB2 | TLN2 | 25361965 | interaction type | N/A | PTMCode2 |
| TLN2 | ITGB2 | 25361965 | interaction type | N/A | PTMCode2 |
| TLN2 | PIP5K1C | 25361965 | interaction type | N/A | PTMCode2 |
| PIP5K1C | TLN2 | 25361965 | interaction type | N/A | PTMCode2 |
| VCL | TLN2 | 25361965 | interaction type | N/A | PTMCode2 |
| TLN2 | VCL | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CDC5L | TLN2 | 20467437 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SGTB | TLN2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| HAT1 | TLN2 | 25348397 | N/A | physical interaction | ComPPI |
| ITGB5 | TLN2 | 24234451 25348397 25448675 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| SKP1 | TLN2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| EXOC8 | TLN2 | 25348397 | N/A | physical interaction | ComPPI |
| UBL7 | TLN2 | 25348397 | N/A | physical interaction | ComPPI |
| DIAPH1 | TLN2 | 25348397 | N/A | physical interaction | ComPPI |
| CLK1 | TLN2 | 25348397 | N/A | physical interaction | ComPPI |
| ITGB2 | TLN2 | 19234221 24234451 25348397 | physical association | anti bait coimmunoprecipitation,far western blotting,pull down | ComPPI,IntAct |
| SYNCRIP | TLN2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| HIF1AN | TLN2 | 24234451 25348397 26972000 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| PIP5K1C | TLN2 | 12422219 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,OmniPath |
| SEM1 | TLN2 | 25348397 | N/A | physical interaction | ComPPI |
| SNF8 | TLN2 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPD | TLN2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TLN2 | TWF2 | 25348397 | N/A | physical interaction | ComPPI |
| TLN2 | NUP93 | 25348397 | N/A | physical interaction | ComPPI |
| TLN2 | ALB | 15174051 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TLN2 | SEM1 | 25348397 | N/A | physical interaction | ComPPI |
| TLN2 | RGCC | 25348397 | N/A | physical interaction | ComPPI |
| TLN2 | DDI2 | 25348397 | N/A | physical interaction | ComPPI |
| TLN2 | TRMT6 | 25348397 | N/A | physical interaction | ComPPI |
| TLN2 | TRMT61A | 25348397 | N/A | physical interaction | ComPPI |
| TLN2 | TTC4 | 25348397 | N/A | physical interaction | ComPPI |
| TLN2 | DGCR8 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TLN2 | CHMP4B | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TLN2 | KANK4 | 25348397 | N/A | physical interaction | ComPPI |
| TLN2 | CCND2 | 25348397 | N/A | physical interaction | ComPPI |
| TLN2 | ABL1 | 19234221 24234451 25348397 | physical association | anti bait coimmunoprecipitation,pull down | ComPPI,IntAct |
| TLN2 | FOS | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| DCUN1D5 | TLN2 | 25348397 | N/A | physical interaction | ComPPI |