GENE：NFKBIZ
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NFKBIZ |
| FullNmae | NFKB inhibitor zeta |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:29805 |
| EnsembleID | ENSG00000144802 |
| Uniprot | Q9BYH8 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NFKBIZ | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NFKBIZ | GO:0000978,GO:0002224,GO:0002317,GO:0002456,GO:0002544,GO:0003712,GO:0005515,GO:0005634,GO:0006338,GO:0009410,GO:0010468,GO:0016607,GO:0019221,GO:0030216,GO:0032980,GO:0036464,GO:0042100,GO:0042789,GO:0043616,GO:0045063,GO:0045190,GO:0045944,GO:0048536,GO:0048873,GO:0050729,GO:0050829,GO:0050852,GO:0051593,GO:0061436,GO:0070897,GO:0070974,GO:0071222,GO:0071560,GO:0072539,GO:0072718,GO:0090594,GO:0097194,GO:0097398,GO:0140459,GO:1904019,GO:1990117,GO:2000321 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| NFKBIZ | hsa:64332 | path:hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NFKBIZ | IFNG | 20876105 21224476 26192618 | interaction type | N/A | ACSN |
| NFKBIZ | LCN2 | 17447895 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| NFKB1 | NFKBIZ | 16513645 19783680 21224476 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| NFKBIZ | RELA | 16513645 21224476 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IFNG | NFKBIZ | 21224476 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | NFKBIZ | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | NFKBIZ | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA1 | NFKBIZ | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | NFKBIZ | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | NFKBIZ | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | NFKBIZ | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | NFKBIZ | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | NFKBIZ | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | NFKBIZ | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | NFKBIZ | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | NFKBIZ | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | NFKBIZ | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | NFKBIZ | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | NFKBIZ | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | NFKBIZ | 20220144 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | NFKBIZ | 20220144 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | NFKBIZ | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000F31F4 | NFKBIZ | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000B59A2 | NFKBIZ | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000AA464 | NFKBIZ | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RBM3 | NFKBIZ | 25348397 | N/A | physical interaction | ComPPI |
| NFKB1 | NFKBIZ | 11356851 14525934 15241416 21988832 24234451 25348397 | physical association | two hybrid,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| NFKB2 | NFKBIZ | 25348397 | N/A | physical interaction | ComPPI |
| STAT3 | NFKBIZ | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| IL6 | NFKBIZ | 24234451 26226212 | association | chromatin immunoprecipitation assay | IntAct |
| ERP29 | NFKBIZ | 24234451 30021884 | physical association | cross-linking study | IntAct |
| NFKB1 | NFKBIZ | 11356851 15241416 16513645 17349209 17561400 19783680 21224476 21988832 27898060 | N/A | N/A | OmniPath |
| NFKBIZ | NFKB1 | 11356851 15241416 16513645 17349209 17561400 19783680 21224476 21988832 27898060 | N/A | N/A | OmniPath |
| NFKBIZ | RELA | 16513645 21224476 27898060 | N/A | N/A | OmniPath |
| NFKBIZ | STAT3 | 19595668 21988832 27898060 | inhibition | N/A | OmniPath |