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GENE：DEGS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DEGS1
FullNmae delta 4-desaturase, sphingolipid 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:13709
EnsembleID ENSG00000143753
Uniprot O15121

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DEGS1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DEGS1 GO:0005515,GO:0005739,GO:0005783,GO:0005789,GO:0005886,GO:0006636,GO:0009055,GO:0016020,GO:0022900,GO:0030148,GO:0031966,GO:0035579,GO:0042284,GO:0042284,GO:0042284,GO:0043217,GO:0046513,GO:0050251

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DEGS1 hsa:8560 path:hsa00600 Sphingolipid metabolism - Homo sapiens (human)
DEGS1 hsa:8560 path:hsa01100 Metabolic pathways - Homo sapiens (human)
DEGS1 hsa:8560 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EGR1 DEGS1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 DEGS1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 DEGS1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 DEGS1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 DEGS1 18922183 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 DEGS1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 DEGS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DEGS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DEGS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DEGS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DEGS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DEGS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 DEGS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC DEGS1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 DEGS1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000F31F4 DEGS1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 DEGS1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EED18 DEGS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004719AB DEGS1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000007FBA DEGS1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 DEGS1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000215483 DEGS1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000042935A DEGS1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000486E0B DEGS1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D DEGS1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA DEGS1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 DEGS1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A DEGS1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA DEGS1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001AFC71 DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000435A77 DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003ACE11 DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 DEGS1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
NUDT21 DEGS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF3E DEGS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
OPRM1 DEGS1 25348397 N/A physical interaction ComPPI
EIF5B DEGS1 25348397 N/A physical interaction ComPPI
PTH1R DEGS1 25348397 N/A physical interaction ComPPI
PYGM DEGS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EGFR DEGS1 14525934 25348397 9188692 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
GTF2F1 DEGS1 25348397 N/A physical interaction ComPPI
SIRT2 DEGS1 25348397 N/A physical interaction ComPPI
APLNR DEGS1 25348397 N/A physical interaction ComPPI
SLC16A1 DEGS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PCMT1 DEGS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CD79A DEGS1 25348397 N/A physical interaction ComPPI
NAGPA DEGS1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FOXP4 DEGS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SF3B3 DEGS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SHMT2 DEGS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UFD1 DEGS1 25348397 N/A physical interaction ComPPI
CPLX2 DEGS1 25348397 N/A physical interaction ComPPI
MOB1A DEGS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RADIL DEGS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
FLOT2 DEGS1 25348397 N/A physical interaction ComPPI
DEGS1 SURF4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DEGS1 EIPR1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DEGS1 NRG1 25348397 N/A physical interaction ComPPI
DEGS1 LSG1 25348397 N/A physical interaction ComPPI
DEGS1 HDGFL2 25348397 N/A physical interaction ComPPI
DEGS1 SUPT6H 25348397 N/A physical interaction ComPPI
DEGS1 CYHR1 25348397 N/A physical interaction ComPPI
DEGS1 NT5E 25348397 N/A physical interaction ComPPI
DEGS1 LPAR6 25348397 N/A physical interaction ComPPI
DEGS1 C4ORF3 25348397 N/A physical interaction ComPPI
DEGS1 SCARA3 25348397 N/A physical interaction ComPPI
DEGS1 TCTN3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DEGS1 NCR3LG1 25348397 N/A physical interaction ComPPI
DEGS1 SLC17A2 25348397 N/A physical interaction ComPPI
DEGS1 PACC1 25348397 N/A physical interaction ComPPI

Visualization










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