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GENE：AHCYL1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol AHCYL1
FullNmae adenosylhomocysteinase like 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:344
EnsembleID ENSG00000168710
Uniprot O43865

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
AHCYL1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
AHCYL1 GO:0003723,GO:0005515,GO:0005737,GO:0005789,GO:0005829,GO:0006378,GO:0006611,GO:0006730,GO:0006915,GO:0010765,GO:0016324,GO:0030234,GO:0031440,GO:0032412,GO:0033353,GO:0038166,GO:0042045,GO:0042802,GO:0044070,GO:0044233,GO:0051592,GO:0070062,GO:1990456

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
AHCYL1 hsa:10768 path:hsa00270 Cysteine and methionine metabolism - Homo sapiens (human)
AHCYL1 hsa:10768 path:hsa01100 Metabolic pathways - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BID AHCYL1 23180781 25416956 physical association two hybrid InnateDB
SRPK1 AHCYL1 23180781 23602568 phosphorylation reaction protein kinase assay InnateDB
AHCYL1 ITPR3 11904675 16754674 29145629 physical association inferred by curator Reactome
AHCYL1 ITPR2 11904675 16754674 29145629 physical association inferred by curator Reactome
AHCYL1 ITPR1 11904675 16754674 29145629 physical association inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
AR AHCYL1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 AHCYL1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 AHCYL1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP63 AHCYL1 17521434 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 AHCYL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA AHCYL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF AHCYL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 AHCYL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 AHCYL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 AHCYL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 AHCYL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS AHCYL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A AHCYL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF AHCYL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC AHCYL1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 AHCYL1 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS0000324096 AHCYL1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
AHCYL1 AHCYL1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ZNF165 AHCYL1 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GEM AHCYL1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PPL AHCYL1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SNRPA AHCYL1 25348397 N/A physical interaction ComPPI
HEXIM2 AHCYL1 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VPS4B AHCYL1 25348397 N/A physical interaction ComPPI
ANP32B AHCYL1 25348397 N/A physical interaction ComPPI
TPD52L2 AHCYL1 25348397 N/A physical interaction ComPPI
SGTA AHCYL1 25348397 N/A physical interaction ComPPI
CD2BP2 AHCYL1 25348397 N/A physical interaction ComPPI
HBQ1 AHCYL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PTS AHCYL1 25348397 N/A physical interaction ComPPI
CDKN2C AHCYL1 24234451 25348397 25416956 25910212 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
RPL37A AHCYL1 25348397 N/A physical interaction ComPPI
MEOX2 AHCYL1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MAB21L3 AHCYL1 25348397 N/A physical interaction ComPPI
SLC23A1 AHCYL1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SKP1 AHCYL1 25348397 N/A physical interaction ComPPI
UBE2D1 AHCYL1 25348397 N/A physical interaction ComPPI
LAGE3 AHCYL1 25348397 N/A physical interaction ComPPI
UBL7 AHCYL1 25348397 N/A physical interaction ComPPI
TACC3 AHCYL1 25348397 N/A physical interaction ComPPI
TLE3 AHCYL1 25348397 N/A physical interaction ComPPI
ZYX AHCYL1 25348397 N/A physical interaction ComPPI
JUN AHCYL1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
TPM2 AHCYL1 25348397 N/A physical interaction ComPPI
UBE2D2 AHCYL1 25348397 N/A physical interaction ComPPI
UBE2L3 AHCYL1 25348397 N/A physical interaction ComPPI
HGS AHCYL1 25348397 N/A physical interaction ComPPI
SERPINH1 AHCYL1 25348397 N/A physical interaction ComPPI
UBA52 AHCYL1 25348397 N/A physical interaction ComPPI
CANX AHCYL1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CSNK1E AHCYL1 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
STIP1 AHCYL1 25348397 N/A physical interaction ComPPI
HSPA5 AHCYL1 25348397 N/A physical interaction ComPPI
SIN3A AHCYL1 25348397 N/A physical interaction ComPPI
PTGES3 AHCYL1 25348397 N/A physical interaction ComPPI
TRIP6 AHCYL1 25348397 N/A physical interaction ComPPI
TXN AHCYL1 25348397 N/A physical interaction ComPPI
C1QBP AHCYL1 25348397 N/A physical interaction ComPPI
ANP32A AHCYL1 25348397 N/A physical interaction ComPPI
PPP2CA AHCYL1 25348397 N/A physical interaction ComPPI
TPM3 AHCYL1 25348397 N/A physical interaction ComPPI
UBE2B AHCYL1 25348397 N/A physical interaction ComPPI
ECT2 AHCYL1 25348397 N/A physical interaction ComPPI
UBA6 AHCYL1 25348397 N/A physical interaction ComPPI
XPO1 AHCYL1 25348397 N/A physical interaction ComPPI
SP100 AHCYL1 25348397 N/A physical interaction ComPPI
TOM1L2 AHCYL1 25348397 N/A physical interaction ComPPI
SUMO2 AHCYL1 25348397 N/A physical interaction ComPPI
UBA2 AHCYL1 25348397 N/A physical interaction ComPPI
SRSF1 AHCYL1 25348397 N/A physical interaction ComPPI
ZRANB2 AHCYL1 25348397 N/A physical interaction ComPPI
SRPK1 AHCYL1 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
SPR AHCYL1 25348397 N/A physical interaction ComPPI
ARRB2 AHCYL1 25348397 N/A physical interaction ComPPI
SOX2 AHCYL1 25348397 N/A physical interaction ComPPI
CCT5 AHCYL1 25348397 N/A physical interaction ComPPI
STAT6 AHCYL1 25348397 N/A physical interaction ComPPI
YAP1 AHCYL1 25348397 N/A physical interaction ComPPI
TTC1 AHCYL1 25348397 N/A physical interaction ComPPI
UBQLN4 AHCYL1 25348397 N/A physical interaction ComPPI
PTPN21 AHCYL1 25348397 N/A physical interaction ComPPI
DOK4 AHCYL1 25348397 N/A physical interaction ComPPI
PSMD4 AHCYL1 25348397 N/A physical interaction ComPPI
EDA AHCYL1 25348397 N/A physical interaction ComPPI
STMN2 AHCYL1 25348397 N/A physical interaction ComPPI
STAM AHCYL1 25348397 N/A physical interaction ComPPI
CDC37 AHCYL1 25348397 N/A physical interaction ComPPI
PSME3 AHCYL1 25348397 N/A physical interaction ComPPI
UBE4B AHCYL1 25348397 N/A physical interaction ComPPI
ELAVL1 AHCYL1 25348397 N/A physical interaction ComPPI
UBQLN1 AHCYL1 25348397 N/A physical interaction ComPPI
SRPK2 AHCYL1 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
DACH1 AHCYL1 25348397 N/A physical interaction ComPPI
PDCD6IP AHCYL1 25348397 N/A physical interaction ComPPI
PITX2 AHCYL1 25348397 N/A physical interaction ComPPI
STMN1 AHCYL1 25348397 N/A physical interaction ComPPI
STUB1 AHCYL1 25348397 N/A physical interaction ComPPI
SOD1 AHCYL1 25348397 N/A physical interaction ComPPI
TGOLN2 AHCYL1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
UBE2V1 AHCYL1 25348397 N/A physical interaction ComPPI
UCHL3 AHCYL1 25348397 N/A physical interaction ComPPI
ITPR1 AHCYL1 12525476 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
TARDBP AHCYL1 25348397 N/A physical interaction ComPPI
UBE2C AHCYL1 25348397 N/A physical interaction ComPPI
TES AHCYL1 25348397 N/A physical interaction ComPPI
SEC24C AHCYL1 25348397 N/A physical interaction ComPPI
EIF3M AHCYL1 25348397 N/A physical interaction ComPPI
SHTN1 AHCYL1 25348397 N/A physical interaction ComPPI
SUGT1 AHCYL1 25348397 N/A physical interaction ComPPI
ECHS1 AHCYL1 25348397 N/A physical interaction ComPPI
PSMD12 AHCYL1 25348397 N/A physical interaction ComPPI
MYL6 AHCYL1 25348397 N/A physical interaction ComPPI
CEP72 AHCYL1 25348397 N/A physical interaction ComPPI
ZNF414 AHCYL1 25348397 N/A physical interaction ComPPI
SEPHS1 AHCYL1 25348397 N/A physical interaction ComPPI
SOX30 AHCYL1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ZNF263 AHCYL1 25348397 N/A physical interaction ComPPI
PSMD9 AHCYL1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SEC24A AHCYL1 25348397 N/A physical interaction ComPPI
GINS4 AHCYL1 25348397 N/A physical interaction ComPPI
PPIL3 AHCYL1 25348397 N/A physical interaction ComPPI
PIP4K2A AHCYL1 25348397 N/A physical interaction ComPPI
PSMD6 AHCYL1 25348397 N/A physical interaction ComPPI
UBXN1 AHCYL1 25348397 N/A physical interaction ComPPI
TKT AHCYL1 25348397 N/A physical interaction ComPPI
ZPR1 AHCYL1 25348397 N/A physical interaction ComPPI
SMAP AHCYL1 25348397 N/A physical interaction ComPPI
SNX3 AHCYL1 25348397 N/A physical interaction ComPPI
CAMKV AHCYL1 25348397 N/A physical interaction ComPPI
SH3BGRL3 AHCYL1 25348397 N/A physical interaction ComPPI
SLX4 AHCYL1 19596235 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HOXC9 AHCYL1 25348397 N/A physical interaction ComPPI
AHCYL1 JOSD2 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AHCYL1 USP42 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AHCYL1 WDR48 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AHCYL1 TBCA 25348397 N/A physical interaction ComPPI
AHCYL1 THADA 25348397 N/A physical interaction ComPPI
AHCYL1 SULT1A1 25348397 N/A physical interaction ComPPI
AHCYL1 TTLL12 25348397 N/A physical interaction ComPPI
AHCYL1 USP34 25348397 N/A physical interaction ComPPI
AHCYL1 TAGLN2 25348397 N/A physical interaction ComPPI
AHCYL1 TMOD3 25348397 N/A physical interaction ComPPI
AHCYL1 SNCG 25348397 N/A physical interaction ComPPI
AHCYL1 SRXN1 25348397 N/A physical interaction ComPPI
AHCYL1 TTC9C 25348397 N/A physical interaction ComPPI
AHCYL1 UFC1 25348397 N/A physical interaction ComPPI
AHCYL1 USP9X 25348397 N/A physical interaction ComPPI
AHCYL1 PSAT1 25348397 N/A physical interaction ComPPI
AHCYL1 SNX12 25348397 N/A physical interaction ComPPI
AHCYL1 TUBB6 25348397 N/A physical interaction ComPPI
AHCYL1 PPM1G 25348397 N/A physical interaction ComPPI
AHCYL1 TPM1 25348397 N/A physical interaction ComPPI
AHCYL1 UFM1 25348397 N/A physical interaction ComPPI
AHCYL1 VPS26A 25348397 N/A physical interaction ComPPI
AHCYL1 ZFYVE19 25348397 N/A physical interaction ComPPI
AHCYL1 FBXL7 25348397 N/A physical interaction ComPPI
AHCYL1 BID 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
AHCYL1 MOV10 25348397 N/A physical interaction ComPPI
AHCYL1 NXF1 25348397 N/A physical interaction ComPPI
AHCYL1 DHX8 25348397 N/A physical interaction ComPPI
AHCYL1 ZC3H3 25348397 N/A physical interaction ComPPI
AHCYL1 ZNF444 25348397 N/A physical interaction ComPPI
AHCYL1 FAM13C 25348397 N/A physical interaction ComPPI
AHCYL1 ANP32E 25348397 N/A physical interaction ComPPI
AHCYL1 CEP128 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
AHCYL1 POC1A 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
AHCYL1 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
AHCYL1 AHCYL2 25348397 N/A physical interaction ComPPI
AHCYL1 RASL10B 25348397 N/A physical interaction ComPPI
AHCYL1 TAFA3 25348397 N/A physical interaction ComPPI
AHCYL1 ABCF2 25348397 N/A physical interaction ComPPI
AHCYL1 FOXD4 25348397 N/A physical interaction ComPPI
AHCYL1 GOLGA8DP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AHCYL1 UACA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AHCYL1 PRDM6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AHCYL1 HSPA6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AHCYL1 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
AHCYL1 MFHAS1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
AHCY AHCYL1 25348397 N/A physical interaction ComPPI
TGIF2LY AHCYL1 25348397 N/A physical interaction ComPPI
TYMS AHCYL1 25348397 N/A physical interaction ComPPI
ATP6V1B2 AHCYL1 25348397 N/A physical interaction ComPPI
BTK29A AHCYL1 25348397 N/A two hybrid ComPPI
SGG AHCYL1 25348397 N/A anti tag coimmunoprecipitation ComPPI
AHCYL1 MTS 14605208 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AHCYL1 AHCYL1 24234451 25416956 physical association two hybrid array,two hybrid prey pooling approach IntAct
NUDCD1 AHCYL1 24234451 29021621 association anti tag coimmunoprecipitation IntAct
EEF1G AHCYL1 24234451 30021884 physical association cross-linking study IntAct
PPP1CB AHCYL1 17635105 27898060 N/A N/A OmniPath
PPP1CA AHCYL1 17635105 27898060 N/A N/A OmniPath
GSK3B AHCYL1 17016520 27898060 N/A N/A OmniPath
PPP1CC AHCYL1 17635105 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B8C77 AHCYL1 27087310 direct interaction,inhibition N/A NPInter

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