GENE：ADD2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ADD2 |
| FullNmae | adducin 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:244 |
| EnsembleID | ENSG00000075340 |
| Uniprot | P35612 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ADD2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ADD2 | GO:0003779,GO:0005200,GO:0005516,GO:0005829,GO:0005856,GO:0005886,GO:0007416,GO:0008290,GO:0014069,GO:0019901,GO:0030036,GO:0030097,GO:0030507,GO:0031410,GO:0032092,GO:0042803,GO:0044853,GO:0046982,GO:0046983,GO:0050900,GO:0050901,GO:0051015,GO:0051015,GO:0051016,GO:0051016,GO:0051017,GO:0065003 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | ADD2 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | ADD2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | ADD2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | ADD2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | ADD2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ADD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ADD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ADD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ADD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ADD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ADD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ADD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | ADD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | ADD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000FC8EB | ADD2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000008F0CF | ADD2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000060AABB | ADD2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000235862 | ADD2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00006097A6 | ADD2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002367FA | ADD2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005F1B8C | ADD2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000383DF4 | ADD2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041FA2C | ADD2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AB32B | ADD2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000043F369 | ADD2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002004E0 | ADD2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000482389 | ADD2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004719AB | ADD2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001EFEC1 | ADD2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000285DCB | ADD2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B7E30 | ADD2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000028DE3F | ADD2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002A71AD | ADD2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003A5E54 | ADD2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003FA24D | ADD2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000427B68 | ADD2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002233F4 | ADD2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CHEK1 | ADD2 | 22135298 | phosphorylation | N/A | PhosphoSite |
| GSK3B | ADD2 | 22135298 | phosphorylation | N/A | PhosphoSite |
| CDK5 | ADD2 | 22135298 | phosphorylation | N/A | PhosphoSite |
| FYN | ADD2 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| PRKCA | ADD2 | 22135298 | phosphorylation | N/A | PhosphoSite |
| PRKCZ | ADD2 | 22135298 | phosphorylation | N/A | PhosphoSite |
| ADD2 | ADD1 | 25361965 | interaction type | N/A | PTMCode2 |
| ADD1 | ADD2 | 25361965 | interaction type | N/A | PTMCode2 |
| ADD2 | FYN | 25361965 | interaction type | N/A | PTMCode2 |
| ADD2 | PTPRZ1 | 25361965 | interaction type | N/A | PTMCode2 |
| PTPRZ1 | ADD2 | 25361965 | interaction type | N/A | PTMCode2 |
| ADD2 | RPH3A | 25361965 | interaction type | N/A | PTMCode2 |
| RPH3A | ADD2 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DEF6 | ADD2 | 25348397 | N/A | physical interaction | ComPPI |
| ROCK1 | ADD2 | 25348397 | N/A | physical interaction | ComPPI |
| DPPA4 | ADD2 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP23 | ADD2 | 25348397 | N/A | physical interaction | ComPPI |
| NUDT12 | ADD2 | 25348397 | N/A | physical interaction | ComPPI |
| RPH3A | ADD2 | 14525934 25348397 27898060 7707875 7999065 9244430 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD,OmniPath |
| SERPINB13 | ADD2 | 25348397 | N/A | physical interaction | ComPPI |
| PTPRG | ADD2 | 25348397 | N/A | physical interaction | ComPPI |
| ADD3 | ADD2 | 25348397 | N/A | physical interaction | ComPPI |
| FYN | ADD2 | 11526103 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| NUFIP1 | ADD2 | 25348397 | N/A | physical interaction | ComPPI |
| ROCK2 | ADD2 | 25348397 | N/A | physical interaction | ComPPI |
| CTDSPL | ADD2 | 25348397 | N/A | physical interaction | ComPPI |
| ADD1 | ADD2 | 14525934 25348397 27898060 7490111 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD,OmniPath |
| LAMP1 | ADD2 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| APP | ADD2 | 25348397 | N/A | physical interaction | ComPPI |
| ALDH16A1 | ADD2 | 25348397 | N/A | physical interaction | ComPPI |
| ADD2 | ANKRD29 | 25348397 | N/A | physical interaction | ComPPI |
| PTPRZ1 | ADD2 | 14525934 16105548 | N/A | experimental interaction detection | HPRD |
| ADD2 | ADD2 | 14525934 7707875 7999065 | N/A | experimental interaction detection | HPRD |
| CALM2 | ADD2 | 14525934 7490111 | N/A | experimental interaction detection | HPRD |
| PRKCD | ADD2 | 14525934 8810272 9679146 | N/A | experimental interaction detection | HPRD |
| PRKACA | ADD2 | 14525934 8810272 9679146 | N/A | experimental interaction detection | HPRD |
| PRKACA | ADD2 | 18452278 19664994 27898060 8810272 9679146 | N/A | N/A | OmniPath |
| PRKCA | ADD2 | 16116087 27898060 8810272 9679146 | inhibition | N/A | OmniPath |
| FYN | ADD2 | 11526103 16765915 27898060 | N/A | N/A | OmniPath |
| PRKCD | ADD2 | 18452278 19664994 27898060 8810272 9679146 | N/A | N/A | OmniPath |
| ROCK1 | ADD2 | 16116087 27898060 8810272 9679146 | N/A | N/A | OmniPath |
| PRKCZ | ADD2 | 16116087 27898060 | inhibition | N/A | OmniPath |
| PTPRZ1 | ADD2 | 16105548 27898060 | N/A | N/A | OmniPath |