GENE：SPAG1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SPAG1 |
| FullNmae | sperm associated antigen 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11212 |
| EnsembleID | ENSG00000104450 |
| Uniprot | Q07617 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SPAG1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SPAG1 | GO:0005525,GO:0005737,GO:0005829,GO:0005829,GO:0007338,GO:0016787,GO:0050821,GO:0070286,GO:0070286,GO:0101031,GO:0120293 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SPAG1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | SPAG1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | SPAG1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | SPAG1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | SPAG1 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | SPAG1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | SPAG1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | SPAG1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | SPAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SPAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SPAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | SPAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | SPAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | SPAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000600E6 | SPAG1 | 17242205 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000003ABC4 | SPAG1 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00002E1509 | SPAG1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B0E50 | SPAG1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E92A8 | SPAG1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PCNA | SPAG1 | 25348397 | N/A | physical interaction | ComPPI |
| KEAP1 | SPAG1 | 25348397 | N/A | physical interaction | ComPPI |
| PRKCA | SPAG1 | 11517287 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| UBC | SPAG1 | 25348397 | N/A | physical interaction | ComPPI |
| CDH1 | SPAG1 | 25348397 | N/A | physical interaction | ComPPI |
| SPAG1 | GNB1 | 16368546 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| SPAG1 | ATL3 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SPAG1 | BBX | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
| PRPF38A | SPAG1 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
| SSR3 | SPAG1 | 24234451 30021884 | physical association | cross-linking study | IntAct |