Gene Information gene info

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GENE：DEFA6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DEFA6
FullNmae defensin alpha 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2765
EnsembleID ENSG00000164822
Uniprot Q01524

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DEFA6 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DEFA6 GO:0002227,GO:0005515,GO:0005576,GO:0005615,GO:0005796,GO:0019731,GO:0030133,GO:0031640,GO:0042803,GO:0050829,GO:0050830,GO:0050832,GO:0051673,GO:0061844,GO:0071222

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DEFA6 hsa:1671 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
DEFA6 hsa:1671 path:hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
DEFA6 hsa:1671 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DEFA6 DEFA6 17088326 23180781 physical association x-ray crystallography InnateDB

Source Target Pmid Interactiontype Methods Database
CTCF DEFA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DEFA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TCF7L2 DEFA6 19221600 trascriptional regulation,stimulation inferred by curator TFlink
TCF4 DEFA6 19221600 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
ZFYVE9 DEFA6 25348397 N/A physical interaction ComPPI
SGTB DEFA6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ACTB DEFA6 25348397 N/A physical interaction ComPPI
DEFA6 APP 25348397 N/A physical interaction ComPPI
DEFA6 UBQLN1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DEFA6 ZFPM1 25348397 N/A physical interaction ComPPI
DEFA6 POTEE 25348397 N/A physical interaction ComPPI
DEFA6 VWA1 25348397 N/A physical interaction ComPPI
DEFA6 PZP 25348397 N/A physical interaction ComPPI
DEFA6 IP6K1 25348397 N/A physical interaction ComPPI
DEFA6 RBPMS2 25348397 N/A physical interaction ComPPI
DEFA6 EXTL3 25348397 N/A physical interaction ComPPI
DEFA6 FBXO11 25348397 N/A physical interaction ComPPI
DEFA6 YAP1 25348397 N/A physical interaction ComPPI
DEFA6 ACTBL2 25348397 N/A physical interaction ComPPI
DEFA6 MIPEP 25348397 N/A physical interaction ComPPI
DEFA6 CTSF 25348397 N/A physical interaction ComPPI
DEFA6 UBQLN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct

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