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GENE：APPL2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol APPL2
FullNmae adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:18242
EnsembleID ENSG00000136044
Uniprot Q8NEU8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
APPL2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
APPL2 GO:0001726,GO:0001786,GO:0002024,GO:0005515,GO:0005634,GO:0005768,GO:0005886,GO:0006606,GO:0007049,GO:0007165,GO:0007179,GO:0009631,GO:0010008,GO:0010008,GO:0010762,GO:0016020,GO:0023052,GO:0031410,GO:0031901,GO:0031982,GO:0032009,GO:0032587,GO:0033211,GO:0034143,GO:0035091,GO:0035729,GO:0036186,GO:0042593,GO:0042802,GO:0042803,GO:0044354,GO:0044877,GO:0045088,GO:0046322,GO:0046325,GO:0046325,GO:0050768,GO:0051289,GO:0060100,GO:0070062,GO:0120162,GO:1900016,GO:1900077,GO:1905303,GO:1905451,GO:2000045,GO:2000178

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FSHR APPL2 17030088 23180781 physical association anti tag coimmunoprecipitation InnateDB
APPL1 APPL2 17030088 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR APPL2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 APPL2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 APPL2 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 APPL2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 APPL2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 APPL2 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 APPL2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 APPL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 APPL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A APPL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 APPL2 20215506 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
APPL2 RAB5A 25361965 interaction type N/A PTMCode2
RAB5A APPL2 25361965 interaction type N/A PTMCode2
APPL2 APPL1 25361965 interaction type N/A PTMCode2
APPL1 APPL2 25361965 interaction type N/A PTMCode2
APPL2 RBBP7 25361965 interaction type N/A PTMCode2
RBBP7 APPL2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
EPM2AIP1 APPL2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LGALS9C APPL2 25348397 N/A physical interaction ComPPI
APPL1 APPL2 14525934 15016378 16189514 23414517 24234451 25348397 25416956 colocalization,physical association two hybrid,physical interaction,mammalian protein protein interaction trap,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,fluorescence microscopy,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
DOK3 APPL2 25348397 N/A physical interaction ComPPI
ATF3 APPL2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NTRK1 APPL2 25348397 N/A physical interaction ComPPI
RAB5A APPL2 14525934 15016378 24234451 25348397 29568061 association experimental interaction detection,physical interaction,in vitro,proximity-dependent biotin identification ComPPI,HPRD,IntAct
ABI2 APPL2 25348397 N/A physical interaction ComPPI
TSC1 APPL2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FSHR APPL2 25348397 N/A physical interaction ComPPI
CRADD APPL2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
POT1 APPL2 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
TINF2 APPL2 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
MLST8 APPL2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
MTA2 APPL2 14525934 15016378 24234451 25348397 association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
TGOLN2 APPL2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5C APPL2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RAB22A APPL2 14525934 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
RUVBL2 APPL2 25348397 N/A physical interaction ComPPI
MAPRE3 APPL2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
SUV39H2 APPL2 23455924 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPL2 RBBP7 14525934 15016378 24234451 25348397 association experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
APPL2 RIPOR1 25348397 N/A physical interaction ComPPI
APPL2 TPM1 25348397 N/A physical interaction ComPPI
APPL2 LIX1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
APPL2 KMT2C 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
APPL2 LINC02875 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
APPL2 LDHAL6B 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
APPL2 RBP7 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
APPL2 CRBN 25348397 N/A physical interaction ComPPI
APPL2 CRLF3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
APPL2 CNMD 25348397 N/A physical interaction ComPPI
APPL2 RAI2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
APPL2 PRR35 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPL2 LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PINK1 APPL2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
YWHAE APPL2 24234451 30021884 physical association cross-linking study IntAct

Visualization










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