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GENE：C1R

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol C1R
FullNmae complement C1r
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1246
EnsembleID ENSG00000159403
Uniprot P00736

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
C1R immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
C1R GO:0004252,GO:0004252,GO:0005509,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0006955,GO:0006958,GO:0008236,GO:0031638,GO:0031638,GO:0042802,GO:0045087,GO:0070062,GO:0072562,GO:0140313

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
C1R hsa:715 path:hsa04145 Phagosome - Homo sapiens (human)
C1R hsa:715 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
C1R hsa:715 path:hsa05133 Pertussis - Homo sapiens (human)
C1R hsa:715 path:hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
C1R hsa:715 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
C1R hsa:715 path:hsa05322 Systemic lupus erythematosus - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR C1R 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA C1R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 C1R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 C1R 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000116F83 C1R 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000007A060 C1R 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000A939F C1R 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 C1R 22135298 phosphorylation N/A PhosphoSite
SERPING1 C1R 25361965 interaction type N/A PTMCode2
C1R SERPING1 25361965 interaction type N/A PTMCode2
C1R C1S 25361965 interaction type N/A PTMCode2
C1S C1R 25361965 interaction type N/A PTMCode2
C1R C1QA 25361965 interaction type N/A PTMCode2
C1QA C1R 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
EP300 C1R 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SERPING1 C1R 14525934 25348397 6282262 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CSNK2A1 C1R 14525934 25348397 8635594 N/A experimental interaction detection,in vivo ComPPI,HPRD
C1QA C1R 10878362 14525934 2372546 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
C1R C1QB 1370572 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
C1R C1S 10092586 12788922 14525934 17996945 2372546 2387866 24234451 25348397 9477945 protein cleavage,physical association experimental interaction detection,molecular sieving,surface plasmon resonance,physical interaction,protease assay,in vitro,in vivo,equilibrium dialysis ComPPI,HPRD,IntAct
C1R PCK1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
C1R C1RL 25348397 N/A physical interaction ComPPI
C1R BIRC2 25348397 N/A physical interaction ComPPI
C1R LRRC15 25348397 N/A physical interaction ComPPI
C1R C1R 14525934 20970424 24234451 9174342 N/A experimental interaction detection,nuclear magnetic resonance HPRD,IntAct
CSNK2A1 C1R 27898060 8635594 N/A N/A OmniPath
CAMK2A C1R 27898060 8635594 N/A N/A OmniPath

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