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GENE：EXOSC8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EXOSC8
FullNmae exosome component 8
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17035
EnsembleID ENSG00000120699
Uniprot Q96B26

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EXOSC8 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EXOSC8 GO:0000176,GO:0000176,GO:0000177,GO:0000177,GO:0000178,GO:0000178,GO:0000467,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0005829,GO:0005829,GO:0006396,GO:0006401,GO:0034427,GO:0034473,GO:0034475,GO:0034476,GO:0035925,GO:0042802,GO:0043231,GO:0043928,GO:0071028,GO:0071035,GO:0071038,GO:0071042,GO:0101019

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EXOSC8 hsa:11340 path:hsa03018 RNA degradation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 EXOSC8 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 EXOSC8 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC EXOSC8 12747840 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 EXOSC8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EXOSC8 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
EXOSC9 EXOSC8 25361965 interaction type N/A PTMCode2
EXOSC8 EXOSC9 25361965 interaction type N/A PTMCode2
EXOSC5 EXOSC8 25361965 interaction type N/A PTMCode2
EXOSC8 EXOSC5 25361965 interaction type N/A PTMCode2
ZFP36 EXOSC8 25361965 interaction type N/A PTMCode2
EXOSC8 ZFP36 25361965 interaction type N/A PTMCode2
EXOSC2 EXOSC8 25361965 interaction type N/A PTMCode2
EXOSC8 EXOSC2 25361965 interaction type N/A PTMCode2
XRN2 EXOSC8 25361965 interaction type N/A PTMCode2
EXOSC8 XRN2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GEM EXOSC8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SNRPC EXOSC8 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC5 EXOSC8 11719186 12364597 12419256 12837249 14525934 15231747 17391830 17942686 21516116 24234451 24336220 25348397 25416956 26186194 26344197 26496610 27898060 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vivo,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct,OmniPath
LMO4 EXOSC8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIAS2 EXOSC8 25348397 N/A two hybrid ComPPI
SNRPB EXOSC8 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HOXB9 EXOSC8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TFAP4 EXOSC8 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FAM90A1 EXOSC8 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LSM1 EXOSC8 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SNAI1 EXOSC8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC1 EXOSC8 15231747 24234451 25043052 25348397 26496610 association,physical association anti tag coimmunoprecipitation,two hybrid,molecular sieving,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 COX5A 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EXOSC8 FRG1 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EXOSC8 TXNDC17 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EXOSC8 DUSP23 24234451 25348397 25416956 25910212 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
EXOSC8 ZFP36 15231747 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EXOSC8 EXOSC2 11719186 14525934 17545563 24234451 25348397 26496610 association anti tag coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
EXOSC8 RASSF1 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOSC8 FHOD1 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOSC8 LSM7 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOSC8 DIS3 11719186 14525934 15231747 20531386 24234451 25348397 association,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
EXOSC8 EXOSC9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,two hybrid,physical interaction,in vivo ComPPI,IntAct
EXOSC8 FOXN3 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOSC8 EXOSC7 11719186 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
EXOSC8 PALS2 11719186 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EXOSC8 MKRN1 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOSC8 XRN2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOSC8 UPF2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOSC8 EXOSC6 11719186 12419256 14525934 15231747 18631361 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
EXOSC8 MTREX 11719186 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
EXOSC8 EXOSC10 14525934 15231747 21255825 24234451 25348397 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOSC8 CWC22 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOSC8 RPP14 11929972 14525934 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,two hybrid array,in vitro,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct,OmniPath
EXOSC8 EXOSC4 11719186 14525934 20531386 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
EXOSC8 XRN1 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
EXOSC8 UBC 25348397 N/A physical interaction ComPPI
EXOSC8 VHL 25348397 N/A physical interaction ComPPI
EXOSC8 DIS3L 20531386 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
EXOSC8 EXOSC3 15231747 20531389 21255825 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
EXOSC8 MDC1 24234451 25348397 29656893 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
EXOSC8 METTL22 25348397 N/A physical interaction ComPPI
EXOSC8 AICDA 21255825 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC8 MKRN9P 25348397 N/A physical interaction ComPPI
EXOSC8 RPA3 25348397 N/A physical interaction ComPPI
EXOSC8 RPA2 25348397 N/A physical interaction ComPPI
EXOSC8 RPA1 25348397 N/A physical interaction ComPPI
EXOSC8 DNAAF10 25348397 N/A physical interaction ComPPI
EXOSC8 CRMP1 25348397 N/A physical interaction ComPPI
EXOSC8 TP53 25348397 N/A physical interaction ComPPI
EXOSC8 REL 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EXOSC8 TCEA2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EXOSC8 USP6 25348397 N/A physical interaction ComPPI
EXOSC8 TXNDC9 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EXOSC8 OTUD4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EXOSC8 AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EXOSC8 COL23A1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EXOSC8 MORN4 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 MOV10 25348397 N/A physical interaction ComPPI
EXOSC8 NXF1 25348397 N/A physical interaction ComPPI
EXOSC8 MPHOSPH6 25348397 N/A physical interaction ComPPI
EXOSC8 HBS1L 25348397 N/A physical interaction ComPPI
EXOSC8 ZCCHC8 25348397 N/A physical interaction ComPPI
EXOSC8 C1D 25348397 N/A physical interaction ComPPI
EXOSC8 PXN 25348397 N/A physical interaction ComPPI
EXOSC8 RBM7 25348397 N/A physical interaction ComPPI
EXOSC8 IFI16 25348397 N/A physical interaction ComPPI
EXOSC8 MED4 25348397 N/A physical interaction ComPPI
EXOSC8 MED20 25348397 N/A physical interaction ComPPI
EXOSC8 MED23 25348397 N/A physical interaction ComPPI
EXOSC8 TMPO 25348397 N/A physical interaction ComPPI
EXOSC8 TMPO 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC8 DUSP13 25348397 N/A physical interaction ComPPI
EXOSC8 DUSP13 25348397 N/A physical interaction ComPPI
EXOSC8 BRCA1 25348397 N/A physical interaction ComPPI
EXOSC8 MTMR3 12419256 24234451 25348397 physical association two hybrid ComPPI,IntAct
EXOSC8 JUN 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
EXOSC8 LNX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 PHF21A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 CNNM3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 RASD1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 SLAIN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 HAPLN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 MYOZ1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 MACIR 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 NTAQ1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 RFC5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 USP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 RUSC1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 WT1-AS 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 KANK2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 C22ORF39 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 FAM161B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 KCNJ11 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 SOCS7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 FOXD4L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 INCA1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 DDIT4L 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC8 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
LSM4 EXOSC8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ATF2 EXOSC8 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EXOSC8 EXOSC8 14525934 15231747 24234451 25416956 physical association two hybrid,two hybrid array,two hybrid prey pooling approach,two hybrid HPRD,IntAct
EXOSC8 CABLES1 24234451 30021884 physical association cross-linking study IntAct
EXOSC8 NIP7 20528918 27898060 9891085 N/A N/A OmniPath

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