GENE：SLIT1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SLIT1 |
| FullNmae | slit guidance ligand 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11085 |
| EnsembleID | ENSG00000187122 |
| Uniprot | O75093 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SLIT1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SLIT1 | GO:0005509,GO:0005515,GO:0005615,GO:0005615,GO:0007097,GO:0007411,GO:0007411,GO:0008045,GO:0008201,GO:0021510,GO:0031290,GO:0033563,GO:0043395,GO:0048495,GO:0048495,GO:0048843,GO:0048846,GO:0048853,GO:0050919,GO:0050919,GO:0051964 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SLIT1 | hsa:6585 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SLIT1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | SLIT1 | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | SLIT1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| MYC | SLIT1 | 12747840 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | SLIT1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | SLIT1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | SLIT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SLIT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SLIT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SLIT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | SLIT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SLIT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | SLIT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | SLIT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | SLIT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00004505E4 | SLIT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00002E728C | SLIT1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B0B46 | SLIT1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000076E54 | SLIT1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000759B6A | SLIT1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006372A | SLIT1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001067D1 | SLIT1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000250A40 | SLIT1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075E2C3 | SLIT1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000011DF | SLIT1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000224AEA | SLIT1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003E1A9 | SLIT1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002F3336 | SLIT1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E5E03 | SLIT1 | 25416803 28735896 | mrna cleavage,inhibition | clip | TarBase |
| URS0000435A77 | SLIT1 | 25416803 28735896 | mrna cleavage,inhibition | clip | TarBase |
| URS000054A671 | SLIT1 | 25416803 28735896 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HOXA1 | SLIT1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| KRTAP10-8 | SLIT1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SLIT1 | GPC1 | 10364234 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| SLIT1 | ROBO1 | 10433822 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| SLIT1 | ATN1 | 14525934 16713569 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| SLIT1 | MTNR1A | 24234451 25348397 26514267 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| SLIT1 | TRIM42 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SLIT1 | FHL5 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SLIT1 | ROBO1 | 10433822 14761655 27898060 | stimulant | N/A | OmniPath |
| SLIT1 | SDC1 | 10433822 14761655 27898060 | stimulant | N/A | OmniPath |
| SLIT1 | GPC1 | 10364234 27898060 | stimulant | N/A | OmniPath |