GENE：MAN1A1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MAN1A1 |
| FullNmae | mannosidase alpha class 1A member 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6821 |
| EnsembleID | ENSG00000111885 |
| Uniprot | P33908 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MAN1A1 | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MAN1A1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MAN1A1 | GO:0000139,GO:0000139,GO:0004571,GO:0004571,GO:0004571,GO:0005509,GO:0005783,GO:0005793,GO:0005794,GO:0005829,GO:0005975,GO:0015923,GO:0016020,GO:0030433,GO:0031410,GO:0045047,GO:0070062,GO:1904382,GO:1904382 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MAN1A1 | hsa:4121 | path:hsa00510 | N-Glycan biosynthesis - Homo sapiens (human) |
| MAN1A1 | hsa:4121 | path:hsa00513 | Various types of N-glycan biosynthesis - Homo sapiens (human) |
| MAN1A1 | hsa:4121 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| MAN1A1 | hsa:4121 | path:hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | MAN1A1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | MAN1A1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | MAN1A1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | MAN1A1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | MAN1A1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | MAN1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MAN1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MAN1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | MAN1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | MAN1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | MAN1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | MAN1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | MAN1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| IGF1R | MAN1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | MAN1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | MAN1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | MAN1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | MAN1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | MAN1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| OCLN | MAN1A1 | 25348397 | N/A | physical interaction | ComPPI |
| CLU | MAN1A1 | 25348397 | N/A | physical interaction | ComPPI |
| CDCP1 | MAN1A1 | 25348397 | N/A | physical interaction | ComPPI |
| PLAUR | MAN1A1 | 25348397 | N/A | physical interaction | ComPPI |
| MMP10 | MAN1A1 | 25348397 | N/A | physical interaction | ComPPI |
| UST | MAN1A1 | 25348397 | N/A | physical interaction | ComPPI |