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GENE：XRN2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol XRN2
FullNmae 5'-3' exoribonuclease 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12836
EnsembleID ENSG00000088930
Uniprot Q9H0D6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
XRN2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
XRN2 GO:0000175,GO:0000956,GO:0001147,GO:0003723,GO:0003723,GO:0004518,GO:0004534,GO:0004534,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0006364,GO:0006369,GO:0006396,GO:0006397,GO:0006401,GO:0007283,GO:0008409,GO:0016020,GO:0016070,GO:0016235,GO:0021766,GO:0030182,GO:0042802,GO:0046872,GO:0060041

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
XRN2 hsa:22803 path:hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human)
XRN2 hsa:22803 path:hsa03018 RNA degradation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DHX58 XRN2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
EIF2AK2 XRN2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
BMI1 XRN2 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR XRN2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 XRN2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 XRN2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 XRN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA XRN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF XRN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 XRN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 XRN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 XRN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS XRN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A XRN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000512C88 XRN2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 XRN2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000043D2C1 XRN2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 XRN2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 XRN2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 XRN2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E XRN2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 XRN2 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK7 XRN2 22135298 phosphorylation N/A PhosphoSite
CDK9 XRN2 22135298 phosphorylation N/A PhosphoSite
DXO XRN2 25361965 interaction type N/A PTMCode2
XRN2 DXO 25361965 interaction type N/A PTMCode2
TARDBP XRN2 25361965 interaction type N/A PTMCode2
XRN2 TARDBP 25361965 interaction type N/A PTMCode2
EXOSC10 XRN2 25361965 interaction type N/A PTMCode2
XRN2 EXOSC10 25361965 interaction type N/A PTMCode2
XRN2 EXOSC8 25361965 interaction type N/A PTMCode2
EXOSC8 XRN2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TXLNA XRN2 25348397 N/A physical interaction ComPPI
SNW1 XRN2 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L XRN2 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PLEKHF2 XRN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DDX21 XRN2 24234451 25348397 25470060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA1 XRN2 25348397 N/A physical interaction ComPPI
LSM3 XRN2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
GABARAPL2 XRN2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
BMI1 XRN2 25348397 N/A physical interaction ComPPI
MCM2 XRN2 25348397 N/A physical interaction ComPPI
SMN1 XRN2 24234451 25348397 26700805 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC8 XRN2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
JUN XRN2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
COPS5 XRN2 25348397 N/A physical interaction ComPPI
PSMA3 XRN2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CUL3 XRN2 25348397 N/A physical interaction ComPPI
NTRK1 XRN2 25348397 N/A physical interaction ComPPI
ENO1 XRN2 25348397 N/A physical interaction ComPPI
EIF2AK2 XRN2 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WWP2 XRN2 25348397 N/A physical interaction ComPPI
RPA1 XRN2 25348397 N/A physical interaction ComPPI
XRN2 EIF5A 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XRN2 EIF6 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XRN2 TARDBP 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XRN2 TOLLIP 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XRN2 COMT 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XRN2 MOCS3 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XRN2 UPF2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XRN2 EIF3L 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XRN2 EXOSC10 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XRN2 DXO 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XRN2 TIPARP 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XRN2 EEF1A1 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
XRN2 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
XRN2 DHX58 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRN2 SIRT7 25348397 N/A physical interaction ComPPI
XRN2 HNRNPA1 22446626 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
XRN2 CUL4B 25348397 N/A physical interaction ComPPI
XRN2 CUL1 25348397 N/A physical interaction ComPPI
XRN2 CAND1 25348397 N/A physical interaction ComPPI
XRN2 DENND5A 25348397 N/A physical interaction ComPPI
XRN2 UBE2A 25348397 N/A physical interaction ComPPI
XRN2 USP19 25348397 N/A physical interaction ComPPI
XRN2 UNC13D 25348397 N/A physical interaction ComPPI
XRN2 XPO1 25348397 N/A physical interaction ComPPI
XRN2 CSNK2A1 25348397 N/A physical interaction,protein kinase assay ComPPI
XRN2 AICDA 25348397 N/A physical interaction ComPPI
XRN2 PAN2 25348397 N/A physical interaction ComPPI
XRN2 EEF1A1P5 25348397 N/A physical interaction ComPPI
XRN2 ATRN 25348397 N/A physical interaction ComPPI
XRN2 CTSC 25348397 N/A physical interaction ComPPI
XRN2 EIF5AL1 25348397 N/A physical interaction ComPPI
XRN2 ALDH1B1 25348397 N/A physical interaction ComPPI
XRN2 PRAME 25348397 N/A physical interaction ComPPI
XRN2 MRPS10 25348397 N/A physical interaction ComPPI
XRN2 RPA3 25348397 N/A physical interaction ComPPI
XRN2 RPA2 25348397 N/A physical interaction ComPPI
XRN2 WWOX 25348397 N/A physical interaction ComPPI
XRN2 ERG 25348397 N/A physical interaction ComPPI
XRN2 LIN28A 25348397 N/A physical interaction ComPPI
XRN2 CDKN2AIPNL 24234451 25348397 26496610 26779609 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRN2 DHX8 25348397 N/A physical interaction ComPPI
XRN2 POLR2A 24234451 25348397 26700805 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
XRN2 NKRF 25348397 N/A physical interaction ComPPI
XRN2 CDKN2AIP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRN2 POLR2B 25348397 N/A physical interaction ComPPI
XRN2 LGALS3BP 25348397 N/A physical interaction ComPPI
XRN2 MAGED2 25348397 N/A physical interaction ComPPI
XRN2 SHMT2 25348397 N/A physical interaction ComPPI
XRN2 MOV10 25348397 N/A physical interaction ComPPI
XRN2 NXF1 25348397 N/A physical interaction ComPPI
XRN2 CUL7 25348397 N/A physical interaction ComPPI
XRN2 OBSL1 25348397 N/A physical interaction ComPPI
XRN2 MCFD2 25348397 N/A physical interaction ComPPI
XRN2 API5 25348397 N/A physical interaction ComPPI
XRN2 HNRNPU 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRN2 CRY2 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
XRN2 EGFR 24189400 24234451 24780295 25348397 association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
XRN2 DCAF7 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
XRN2 FOXA1 25348397 N/A physical interaction ComPPI
XRN2 BRCA1 25348397 N/A physical interaction ComPPI
XRN2 YAP1 25348397 N/A physical interaction ComPPI
XRN2 KDM1A 25348397 N/A pull down,physical interaction ComPPI
XRN2 MAP1LC3A 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
XRN2 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
XRN2 GABARAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
XRN2 MCM7 23764002 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
XRN2 MNDA 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
XRN2 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
XRN2 RRP1B 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
KPNA6 XRN2 25348397 N/A physical interaction ComPPI
XPO7 XRN2 25348397 N/A physical interaction ComPPI
MRPL4 XRN2 25348397 N/A physical interaction ComPPI
CFAP58 XRN2 25348397 N/A physical interaction ComPPI
XRN2 XRN2 24234451 physical association two hybrid array,two hybrid prey pooling approach IntAct
MKI67 XRN2 24234451 26949251 association anti tag coimmunoprecipitation IntAct
METTL3 XRN2 24234451 29507755 association anti tag coimmunoprecipitation IntAct
XRN2 CPLANE1 24234451 30021884 physical association cross-linking study IntAct
XRN2 IWS1 24234451 30021884 physical association cross-linking study IntAct
DHX58 XRN2 21903422 27898060 N/A N/A OmniPath

Visualization










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