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GENE：VAMP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol VAMP2
FullNmae vesicle associated membrane protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12643
EnsembleID ENSG00000220205
Uniprot P63027

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
VAMP2 lysosomal_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
VAMP2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
VAMP2 GO:0000149,GO:0005484,GO:0005515,GO:0005516,GO:0005543,GO:0005802,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0006887,GO:0006906,GO:0006906,GO:0008021,GO:0008021,GO:0009749,GO:0015031,GO:0016020,GO:0016079,GO:0016079,GO:0016192,GO:0017075,GO:0017075,GO:0017156,GO:0017157,GO:0019905,GO:0019905,GO:0030136,GO:0030141,GO:0030667,GO:0030669,GO:0030672,GO:0030672,GO:0031201,GO:0031201,GO:0031201,GO:0031410,GO:0031982,GO:0032869,GO:0035493,GO:0042589,GO:0043001,GO:0043005,GO:0043231,GO:0043308,GO:0044306,GO:0045202,GO:0048306,GO:0048471,GO:0048488,GO:0060203,GO:0060291,GO:0060627,GO:0061025,GO:0061202,GO:0065003,GO:0070032,GO:0070033,GO:0070044,GO:0070083,GO:0090316,GO:1902259

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
VAMP2 hsa:6844 path:hsa04130 SNARE interactions in vesicular transport - Homo sapiens (human)
VAMP2 hsa:6844 path:hsa04721 Synaptic vesicle cycle - Homo sapiens (human)
VAMP2 hsa:6844 path:hsa04911 Insulin secretion - Homo sapiens (human)
VAMP2 hsa:6844 path:hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human)
VAMP2 hsa:6844 path:hsa04970 Salivary secretion - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EGR1 VAMP2 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR VAMP2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
EGR1 VAMP2 18971253 8774732 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
ETS1 VAMP2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 VAMP2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC VAMP2 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SP1 VAMP2 8774732 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
FOXP3 VAMP2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 VAMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA VAMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF VAMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 VAMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 VAMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 VAMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 VAMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS VAMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A VAMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF VAMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 VAMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 VAMP2 8774732 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 VAMP2 14697198 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00000EED18 VAMP2 14697198 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000000B1C9 VAMP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000034B6F5 VAMP2 25416803 25481410 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
HSPA8 VAMP2 25348397 N/A physical interaction ComPPI
TAX1BP3 VAMP2 25348397 N/A physical interaction ComPPI
GET3 VAMP2 25348397 N/A physical interaction ComPPI
STX11 VAMP2 10036234 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SNAP29 VAMP2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
VAMP2 STX1A 10100611 14525934 24234451 25348397 9030619 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach ComPPI,HPRD,IntAct
VAMP2 STX4 10194441 10820264 12417022 12517971 14525934 24234451 25348397 25416956 27898060 8760387 8770861 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct,OmniPath
VAMP2 SYP 12181340 12485399 14525934 18706977 20114047 21645620 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
VAMP2 SNAP25 14525934 25348397 7961655 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
VAMP2 STX1B 12093152 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
VAMP2 STXBP2 12773094 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
VAMP2 SNAP23 10713150 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
VAMP2 VAMP8 10336434 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
VAMP2 RABAC1 14525934 25348397 9341137 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
VAMP2 CPLX1 11832227 14525934 21785412 21785414 24234451 25348397 physical association experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD,IntAct
VAMP2 VAPA 14525934 25348397 9657962 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
VAMP2 VAPB 14525934 25348397 9920726 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
VAMP2 SYPL1 10370136 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
VAMP2 TRPC3 14525934 15327778 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
VAMP2 PRKD3 14525934 17196367 24234451 25348397 27898060 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,in vitro,in vivo,confocal microscopy,two hybrid ComPPI,HPRD,IntAct,OmniPath
VAMP2 STXBP3 25348397 N/A physical interaction ComPPI
VAMP2 STX2 25348397 N/A physical interaction ComPPI
VAMP2 STX3 25348397 N/A physical interaction ComPPI
VAMP2 BCAP31 25348397 N/A physical interaction ComPPI
VAMP2 NAPA 25348397 N/A physical interaction ComPPI
VAMP2 UNC13B 25348397 N/A physical interaction ComPPI
VAMP2 VAMP3 25348397 N/A physical interaction ComPPI
VAMP2 BAG6 25348397 N/A physical interaction ComPPI
VAMP2 SYT1 25348397 N/A physical interaction ComPPI
VAMP2 HGS 25348397 N/A physical interaction ComPPI
VAMP2 ATP13A2 22645275 24234451 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
VAMP2 PRDX5 25348397 N/A physical interaction ComPPI
VAMP2 ABCC2 25348397 N/A physical interaction ComPPI
VAMP2 S100A16 25348397 N/A physical interaction ComPPI
VAMP2 TDP1 25348397 N/A physical interaction ComPPI
VAMP2 USP7 25348397 N/A physical interaction ComPPI
VAMP2 ACAD9 25348397 N/A physical interaction ComPPI
VAMP2 SEPTIN9 25348397 N/A physical interaction ComPPI
VAMP2 TMED10 25348397 N/A physical interaction ComPPI
VAMP2 ILF3 25348397 N/A physical interaction ComPPI
VAMP2 RPS12 25348397 N/A physical interaction ComPPI
VAMP2 SLC25A6 25348397 N/A physical interaction ComPPI
VAMP2 SEC22B 25348397 N/A physical interaction ComPPI
VAMP2 ATP6V0A1 25348397 N/A physical interaction ComPPI
VAMP2 UBE2M 25348397 N/A physical interaction ComPPI
VAMP2 UBA52 25348397 N/A physical interaction ComPPI
VAMP2 FLOT1 25348397 N/A physical interaction ComPPI
VAMP2 SF1 25348397 N/A physical interaction ComPPI
VAMP2 SLC30A5 25348397 N/A physical interaction ComPPI
VAMP2 UBAP2L 25348397 N/A physical interaction ComPPI
VAMP2 ACAA2 25348397 N/A physical interaction ComPPI
VAMP2 FLOT2 25348397 N/A physical interaction ComPPI
VAMP2 UBXN1 25348397 N/A physical interaction ComPPI
VAMP2 SFXN3 25348397 N/A physical interaction ComPPI
VAMP2 HSD17B4 25348397 N/A physical interaction ComPPI
VAMP2 SCFD1 25348397 N/A physical interaction ComPPI
VAMP2 TIMM50 25348397 N/A physical interaction ComPPI
VAMP2 TRAP1 25348397 N/A physical interaction ComPPI
VAMP2 LAMTOR3 25348397 N/A physical interaction ComPPI
VAMP2 IQCB1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VAMP2 ATP4A 25348397 N/A physical interaction ComPPI
VAMP2 FKBP2 25348397 N/A physical interaction ComPPI
VAMP2 EXOC3 25348397 N/A physical interaction ComPPI
VAMP2 STX7 25348397 N/A physical interaction ComPPI
VAMP2 STX12 25348397 N/A physical interaction ComPPI
VAMP2 NUFIP1 25348397 N/A physical interaction ComPPI
VAMP2 DGUOK 25348397 N/A physical interaction ComPPI
VAMP2 STX19 25348397 N/A physical interaction ComPPI
VAMP2 LPAR1 25348397 N/A physical interaction ComPPI
VAMP2 TCTN2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
VAMP2 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
VAMP2 TMEM216 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
VAMP2 HUWE1 25348397 N/A physical interaction ComPPI
VAMP2 PPM1H 25348397 N/A physical interaction ComPPI
VAMP2 WDFY1 25348397 N/A physical interaction ComPPI
VAMP2 TPCN2 25348397 N/A physical interaction ComPPI
VAMP2 MUC1 25348397 N/A physical interaction ComPPI
VAMP2 LMNA 25348397 N/A physical interaction ComPPI
VAMP2 ERGIC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VAMP2 CREB3L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VAMP2 SLC7A14 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VAMP2 KASH5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VAMP2 JAGN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VAMP2 ARL13B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VAMP2 SLC30A8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VAMP2 HIBADH 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VAMP2 EBP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VAMP2 TGOLN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
VAMP2 LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CALM1 VAMP2 25348397 N/A physical interaction ComPPI
VAMP2 DNAJC5 24234451 29997244 physical association bioluminescence resonance energy transfer IntAct

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