Gene Information gene info

GENE:APLF

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol APLF
FullNmae aprataxin and PNKP like factor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:28724
EnsembleID ENSG00000169621
Uniprot Q8IW19

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
APLF immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
APLF GO:0000012,GO:0000166,GO:0003906,GO:0003906,GO:0004520,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006302,GO:0006302,GO:0006303,GO:0006457,GO:0006974,GO:0007566,GO:0008408,GO:0010717,GO:0035861,GO:0035861,GO:0042393,GO:0044183,GO:0045191,GO:0046872,GO:0051106,GO:0071168,GO:0072572,GO:0090734,GO:0140713,GO:0140861,GO:0160002

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APP APLF 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
AR APLF 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 APLF 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 APLF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA APLF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF APLF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 APLF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 APLF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 APLF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 APLF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS APLF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATM APLF 18077224 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122F23 APLF 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D793 APLF 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD APLF 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003CCBB9 APLF 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ATM APLF 22135298 phosphorylation N/A PhosphoSite
XRCC1 APLF 25361965 interaction type N/A PTMCode2
APLF XRCC1 25361965 interaction type N/A PTMCode2
APLF XRCC4 25361965 interaction type N/A PTMCode2
XRCC4 APLF 25361965 interaction type N/A PTMCode2
APLF LIG4 25361965 interaction type N/A PTMCode2
LIG4 APLF 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GMCL1 APLF 25348397 N/A two hybrid,physical interaction ComPPI
CST1 APLF 25348397 N/A physical interaction ComPPI
MSH3 APLF 25348397 N/A physical interaction ComPPI
POLB APLF 25348397 N/A physical interaction ComPPI
H2BC4 APLF 25348397 N/A physical interaction ComPPI
H2AC11 APLF 25348397 N/A physical interaction ComPPI
APLF XRCC1 14525934 17353262 17396150 23178593 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,far western blotting,filter binding,pull down,physical interaction,fluorescence microscopy,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
APLF CHD1L 25348397 N/A physical interaction ComPPI
APLF H3-4 25348397 N/A physical interaction ComPPI
APLF PARP1 17396150 18172500 20098424 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction,enzymatic study ComPPI,IntAct
APLF XRCC5 17396150 20098424 23178593 24234451 25348397 association,physical association anti tag coimmunoprecipitation,two hybrid,filter binding,fluorescence polarization spectroscopy,pull down,physical interaction ComPPI,IntAct
APLF APP 25348397 N/A physical interaction ComPPI
APLF FBXO25 25348397 N/A physical interaction ComPPI
APLF GMCL2 25348397 N/A physical interaction ComPPI
APLF MACROH2A2 25348397 N/A physical interaction ComPPI
APLF MACROH2A1 25348397 N/A physical interaction ComPPI
APLF SUPT16H 25348397 N/A physical interaction ComPPI
APLF LIG3 17396150 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
APLF PARP2 21812934 24234451 25348397 adp ribosylation reaction protein array,physical interaction ComPPI,IntAct
APLF XRCC6 17396150 23178593 24234451 25348397 association,physical association filter binding,fluorescence polarization spectroscopy,pull down,physical interaction ComPPI,IntAct
APLF HLTF 25348397 N/A physical interaction ComPPI
APLF H2BC11 25348397 N/A physical interaction ComPPI
APLF H2AC21 25348397 N/A physical interaction ComPPI
APLF XRCC4 14525934 17353262 17396150 23178593 24234451 25348397 physical association two hybrid,experimental interaction detection,filter binding,pull down,physical interaction ComPPI,HPRD,IntAct
APLF XPC 25348397 N/A physical interaction ComPPI
APLF TDP1 25348397 N/A physical interaction ComPPI
APLF TOP1 17396150 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
APLF SSRP1 25348397 N/A physical interaction ComPPI
APLF ZG16B 25348397 N/A physical interaction ComPPI
APLF CST4 25348397 N/A physical interaction ComPPI
APLF H2BC1 25348397 N/A physical interaction ComPPI
APLF H2AC20 25348397 N/A physical interaction ComPPI
APLF RECQL 17396150 24234451 25348397 association pull down ComPPI,IntAct
APLF RPS3A 17396150 24234451 25348397 association pull down ComPPI,IntAct
APLF PRKDC 17396150 24234451 25348397 association pull down ComPPI,IntAct
APLF YBX1 22118625 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CETN2 APLF 25348397 N/A physical interaction ComPPI
LIG4 APLF 14525934 17396150 23178593 24234451 25348397 physical association experimental interaction detection,filter binding,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
RPA1 APLF 17396150 24234451 25348397 association pull down ComPPI,IntAct
APLF APLF 14525934 17396150 N/A experimental interaction detection HPRD
APLF IRX5 14525934 17396150 N/A experimental interaction detection HPRD
ATM APLF 17507382 18077224 27898060 N/A N/A OmniPath
APLF PARP1 17396150 18172500 20098424 26186194 27898060 stimulant N/A OmniPath

Visualization