GENE：PPP3CC
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PPP3CC |
| FullNmae | protein phosphatase 3 catalytic subunit gamma |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9316 |
| EnsembleID | ENSG00000120910 |
| Uniprot | P48454 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PPP3CC | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PPP3CC | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PPP3CC | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PPP3CC | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PPP3CC | GO:0004723,GO:0005515,GO:0005516,GO:0005737,GO:0005737,GO:0005739,GO:0005829,GO:0005829,GO:0005955,GO:0005955,GO:0006470,GO:0008287,GO:0017018,GO:0033173,GO:0033192,GO:0033192,GO:0046872,GO:0070886,GO:0097720,GO:0098793,GO:0098978,GO:1900244,GO:1905665,GO:1905949 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PPP3CC | hsa:5533 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04218 | Cellular senescence - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04720 | Long-term potentiation - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa04924 | Renin secretion - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa05014 | Amyotrophic lateral sclerosis - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa05020 | Prion disease - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa05152 | Tuberculosis - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa05166 | Human T-cell leukemia virus 1 infection - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human) |
| PPP3CC | hsa:5533 | path:hsa05417 | Lipid and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | PPP3CC | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | PPP3CC | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | PPP3CC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PPP3CC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | PPP3CC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PPP3CC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | PPP3CC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | PPP3CC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| THAP7 | PPP3CC | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| CDR2 | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| KEAP1 | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| NFATC1 | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| UNC119 | PPP3CC | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SDC2 | PPP3CC | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| GSK3B | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| HAX1 | PPP3CC | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| GSK3A | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| PDHB | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| ARID3B | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| BMPR1B | PPP3CC | 14525934 15761153 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| AMPH | PPP3CC | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| BCL2 | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| NFATC4 | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| CABIN1 | PPP3CC | 11714752 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| LRRC41 | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| IGFBP6 | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| PPP3R1 | PPP3CC | 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| MLH1 | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| ESS2 | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| RCAN1 | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| RCAN2 | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| PPP3CB | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| PPP3CC | APP | 25348397 | N/A | physical interaction | ComPPI |
| PPP3CC | CSNK2B | 21988832 24234451 25348397 | colocalization,physical association | two hybrid,physical interaction,confocal microscopy | ComPPI,IntAct |
| PPP3CC | ITPKC | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PPP3CC | RCAN3 | 25348397 | N/A | physical interaction | ComPPI |
| PPP3CC | ARMT1 | 25348397 | N/A | physical interaction | ComPPI |
| PPP3CC | LBH | 25348397 | N/A | physical interaction | ComPPI |
| PPP3CC | PI4KA | 25348397 | N/A | physical interaction | ComPPI |
| PPP3CC | TMEM200A | 25348397 | N/A | physical interaction | ComPPI |
| PPP3CC | DEFA1 | 25348397 | N/A | physical interaction | ComPPI |
| PPP3CC | KLRG2 | 25348397 | N/A | physical interaction | ComPPI |
| PPP3CC | CRTC2 | 25348397 | N/A | physical interaction | ComPPI |
| PPP3CC | SRBD1 | 25348397 | N/A | physical interaction | ComPPI |
| PPP3CC | TAFA3 | 25348397 | N/A | physical interaction | ComPPI |
| PPP3CC | ARHGAP44 | 25348397 | N/A | physical interaction | ComPPI |
| PPP3CC | ARHGAP22 | 25348397 | N/A | physical interaction | ComPPI |
| PPP3CC | SPATA33 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CSN2 | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| SIK3 | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| PPP3CC | TGFBR1 | 14525934 15761153 | N/A | experimental interaction detection | HPRD |
| PPP3CC | DNM1 | 20496096 27898060 8052858 | stimulant | N/A | OmniPath |
| PPP3CC | PRKAR2A | 27898060 9660947 | N/A | N/A | OmniPath |
| PPP3CC | VASP | 27898060 7656973 | N/A | N/A | OmniPath |
| PPP3CC | FLNA | 16442073 27898060 | inhibition | N/A | OmniPath |
| PPP3CC | PPP1R1B | 10217279 12065642 27898060 | N/A | N/A | OmniPath |
| PPP3CC | CSNK1E | 27898060 9430669 | N/A | N/A | OmniPath |
| PPP3CC | DNM2 | 20496096 27898060 | N/A | N/A | OmniPath |
| PPP3CC | KSR2 | 19560418 27898060 | N/A | N/A | OmniPath |
| PPP3CC | BAD | 10195903 22820751 27898060 | stimulant | N/A | OmniPath |
| PPP3CC | CRYAA | 2548498 27898060 | N/A | N/A | OmniPath |
| PPP3CC | RCAN1 | 12063245 27898060 | N/A | N/A | OmniPath |
| PPP3CC | MAPT | 15959850 16262633 27898060 9660947 | N/A | N/A | OmniPath |
| PPP3CC | GSK3B | 19659461 27898060 | N/A | N/A | OmniPath |
| PPP3CC | HSPB1 | 27898060 7510704 | N/A | N/A | OmniPath |
| PPP3CC | JUN | 17215518 27898060 | N/A | N/A | OmniPath |
| PPP3CC | NFATC2 | 11030334 11062529 18676376 27898060 9660947 | stimulant | N/A | OmniPath |
| PPP3CC | ELK1 | 10329725 27898060 | N/A | N/A | OmniPath |
| PPP3CC | NFATC1 | 11062529 18676376 27898060 | stimulant | N/A | OmniPath |
| PPP3CC | PPP1R1A | 11278334 27898060 | N/A | N/A | OmniPath |
| PPP3CC | NEFH | 20031277 27898060 | N/A | N/A | OmniPath |
| PPP3CC | CANX | 20700529 27898060 | N/A | N/A | OmniPath |
| PPP3CC | DNM1L | 17721437 18838687 27898060 | stimulant | N/A | OmniPath |
| PPP3CC | SSH1 | 15671020 27898060 | N/A | N/A | OmniPath |
| PPP3CC | GAD1 | 15147202 27898060 7896780 | N/A | N/A | OmniPath |
| PPP3CC | GAD2 | 15147202 27898060 | N/A | N/A | OmniPath |
| PPP3CC | SLC10A1 | 12065290 27898060 | N/A | N/A | OmniPath |