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GENE：PPP3R1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PPP3R1
FullNmae protein phosphatase 3 regulatory subunit B, alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9317
EnsembleID ENSG00000221823
Uniprot P63098

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PPP3R1 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPP3R1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPP3R1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPP3R1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PPP3R1 GO:0001569,GO:0001837,GO:0004723,GO:0005509,GO:0005515,GO:0005516,GO:0005654,GO:0005829,GO:0005829,GO:0005955,GO:0005955,GO:0005955,GO:0006470,GO:0006606,GO:0007507,GO:0008287,GO:0008597,GO:0016018,GO:0019902,GO:0019902,GO:0019904,GO:0022011,GO:0033173,GO:0042383,GO:0045944,GO:0060487,GO:0070886,GO:0097720,GO:0098685,GO:0098686,GO:0098688,GO:0098693,GO:0098794,GO:0098978,GO:0099149,GO:0099170,GO:1905665,GO:1905949

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PPP3R1 hsa:5534 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04218 Cellular senescence - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04360 Axon guidance - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04720 Long-term potentiation - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa04924 Renin secretion - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa05020 Prion disease - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa05031 Amphetamine addiction - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa05152 Tuberculosis - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
PPP3R1 hsa:5534 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PPP3CB PPP3R1 10195903 11015619 18296442 24243840 26192618 29145629 7593193 association,physical association inferred by curator ACSN,Reactome
PPP3R1 BAD 10195903 26192618 7593193 interaction type N/A ACSN
BCL6 PPP3R1 19965633 23180781 physical association anti tag coimmunoprecipitation InnateDB
PPP3R1 PPP3CA 11015619 18296442 24243840 29145629 physical association inferred by curator Reactome
PPP3R1 NFATC2 10860980 11030334 12975316 17502104 29145629 8576111 8631904 8799126 9727000 physical association inferred by curator Reactome
NFATC1 PPP3R1 10860980 11030334 12015605 12975316 16880514 16920709 17502104 19851316 29145629 8576111 8631904 8799126 9727000 physical association inferred by curator Reactome
PPP3R1 NFATC3 10860980 11030334 12975316 17502104 29145629 8576111 8631904 8799126 9727000 physical association inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
AR PPP3R1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 PPP3R1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 PPP3R1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PPP3R1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PPP3R1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 PPP3R1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PPP3R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PPP3R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PPP3R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PPP3R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PPP3R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PPP3R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PPP3R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PPP3R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 PPP3R1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,experimental interaction detection TarBase
URS0000345DEB PPP3R1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000EED18 PPP3R1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000003ABC4 PPP3R1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00004B4B85 PPP3R1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005CCD18 PPP3R1 22100165 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000CBE63 PPP3R1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000081E1F PPP3R1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002A71AD PPP3R1 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F PPP3R1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 PPP3R1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000202460 PPP3R1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000018D2BE PPP3R1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000049FAE8 PPP3R1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E PPP3R1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 PPP3R1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000007FBA PPP3R1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003A5E54 PPP3R1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002F3336 PPP3R1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A PPP3R1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000170D8B PPP3R1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 PPP3R1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 PPP3R1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 PPP3R1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 PPP3R1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA PPP3R1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 PPP3R1 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PPP3R1 BCL2 25361965 interaction type N/A PTMCode2
BCL2 PPP3R1 25361965 interaction type N/A PTMCode2
PPP3R1 PPP3CB 25361965 interaction type N/A PTMCode2
PPP3CB PPP3R1 25361965 interaction type N/A PTMCode2
PPP3R1 PPP3CA 25361965 interaction type N/A PTMCode2
PPP3CA PPP3R1 25361965 interaction type N/A PTMCode2
PPP3R1 NFATC2 25361965 interaction type N/A PTMCode2
NFATC2 PPP3R1 25361965 interaction type N/A PTMCode2
PPP3R1 PPIA 25361965 interaction type N/A PTMCode2
PPIA PPP3R1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CALM1 PPP3R1 25348397 N/A anti bait coimmunoprecipitation ComPPI
CABP5 PPP3R1 25348397 N/A physical interaction ComPPI
PPP3R1 CABP2 11108966 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PPP3R1 PPP3CA 11439183 14525934 19896943 24234451 25348397 25416956 8524402 association,physical association experimental interaction detection,light scattering,molecular sieving,pull down,x-ray crystallography,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
PPP3R1 NFATC1 14525934 16473827 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PPP3R1 NFATC2 14525934 16473827 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PPP3R1 MAP3K5 14525934 16648474 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD,IntAct
PPP3R1 PPIA 25348397 N/A physical interaction ComPPI
PPP3R1 CABP1 25348397 N/A physical interaction ComPPI
PPP3R1 ELAVL1 25348397 N/A physical interaction ComPPI
PPP3R1 PSMA7 21256111 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PPP3R1 PDE4D 25348397 N/A physical interaction ComPPI
PPP3R1 TRAF3 25348397 N/A physical interaction ComPPI
PPP3R1 IQCB1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP3R1 NAP1L2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PPP3R1 TP53 25348397 N/A physical interaction ComPPI
PPP3R1 PABIR1 25348397 N/A physical interaction ComPPI
PPP3R1 FCGR2A 25348397 N/A physical interaction ComPPI
PPP3R1 PDHB 25348397 N/A physical interaction ComPPI
PPP3R1 RCAN3 25348397 N/A physical interaction ComPPI
PPP3R1 PPP3CC 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PPP3R1 RCAN2 25348397 N/A physical interaction ComPPI
PPP3R1 MYH7 25348397 N/A physical interaction ComPPI
PPP3R1 TINF2 25348397 N/A physical interaction ComPPI
PPP3R1 PPP3CB 25348397 N/A physical interaction ComPPI
PPP3R1 RCAN1 25348397 N/A physical interaction ComPPI
PPP3R1 DEFA1 25348397 N/A physical interaction ComPPI
PPP3R1 TMEM200A 25348397 N/A physical interaction ComPPI
PPP3R1 KLRG2 25348397 N/A physical interaction ComPPI
PPP3R1 ESS2 25348397 N/A physical interaction ComPPI
PPP3R1 SMPD3 25348397 N/A physical interaction ComPPI
PPP3R1 CDR2 25348397 N/A physical interaction ComPPI
PPP3R1 ARHGAP22 25348397 N/A physical interaction ComPPI
PPP3R1 IGFBP6 25348397 N/A physical interaction ComPPI
PPP3R1 CRTC2 25348397 N/A physical interaction ComPPI
PPP3R1 SRBD1 25348397 N/A physical interaction ComPPI
PPP3R1 DGUOK 25348397 N/A physical interaction ComPPI
PPP3R1 NUFIP1 25348397 N/A physical interaction ComPPI
PPP3R1 TRIM25 25348397 N/A physical interaction ComPPI
PPP3R1 BCL2 15757646 24234451 25348397 colocalization pull down,fluorescence microscopy ComPPI,IntAct
PPP3R1 USP14 19896943 24234451 25348397 association pull down ComPPI,IntAct
PPP3R1 CHRNA6 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
PPP3R1 AKAP5 22343722 24234451 25348397 physical association light scattering,molecular sieving,x-ray crystallography ComPPI,IntAct
CALM2 PPP3R1 15757646 24234451 physical association anti bait coimmunoprecipitation IntAct

Visualization










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