GENE：ACKR1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ACKR1 |
| FullNmae | atypical chemokine receptor 1 (Duffy blood group) |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:4035 |
| EnsembleID | ENSG00000213088 |
| Uniprot | Q16570 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ACKR1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ACKR1 | GO:0004888,GO:0004930,GO:0005769,GO:0005886,GO:0006952,GO:0006954,GO:0007186,GO:0019957,GO:0019957,GO:0032642,GO:0038023,GO:0055037,GO:0070098 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ACKR1 | hsa:2532 | path:hsa05144 | Malaria - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CXCL8 | ACKR1 | 15720550 23180781 7592830 8132497 9195930 | physical association | competition binding,saturation binding | InnateDB |
| CXCL1 | ACKR1 | 23180781 7592830 8132497 9195930 | physical association | competition binding | InnateDB |
| CCL2 | ACKR1 | 23180781 8132497 | physical association | competition binding | InnateDB |
| PF4 | ACKR1 | 23180781 8132497 | physical association | competition binding | InnateDB |
| ACKR1 | CCL5 | 23180781 7592830 8132497 9195930 | physical association | competition binding | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | ACKR1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | ACKR1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | ACKR1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ACKR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ACKR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ACKR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DBP | ACKR1 | 22122911 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CXCL8 | ACKR1 | 14525934 17416748 25348397 9921412 | N/A | affinity chromatography technology,experimental interaction detection,physical interaction,biochemical | ComPPI,HPRD |
| CXCL1 | ACKR1 | 14525934 25348397 7592830 | N/A | experimental interaction detection,physical interaction,biochemical | ComPPI,HPRD |
| CCL2 | ACKR1 | 13679391 14525934 17416748 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| MTNR1B | ACKR1 | 25348397 | N/A | physical interaction | ComPPI |
| CCL5 | ACKR1 | 12081195 14525934 17416748 | N/A | experimental interaction detection | HPRD |
| ACKR1 | CXCL5 | 13679391 14525934 | N/A | experimental interaction detection | HPRD |
| ACKR1 | CCL17 | 13679391 14525934 | N/A | experimental interaction detection | HPRD |
| ACKR1 | CCL8 | 13679391 14525934 | N/A | experimental interaction detection | HPRD |
| CXCL8 | ACKR1 | 10206993 15720550 17416748 24218476 27898060 7592830 8132497 8558064 9195930 9921412 | N/A | N/A | OmniPath |
| CCL5 | ACKR1 | 12081195 17416748 24218476 27898060 7592830 8132497 9195930 | N/A | N/A | OmniPath |
| CCL2 | ACKR1 | 13679391 17416748 24218476 27898060 8132497 | N/A | N/A | OmniPath |
| PF4 | ACKR1 | 27898060 8132497 | N/A | N/A | OmniPath |
| DNAJC9 | ACKR1 | 27898060 8132497 | N/A | N/A | OmniPath |
| CXCL1 | ACKR1 | 12734373 24218476 27898060 7592830 8132497 9195930 | stimulant | N/A | OmniPath |