GENE：AFF3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | AFF3 |
| FullNmae | ALF transcription elongation factor 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6473 |
| EnsembleID | ENSG00000144218 |
| Uniprot | P51826 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| AFF3 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| AFF3 | GO:0003690,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0010468,GO:0016604,GO:0032783,GO:0034612,GO:0035116 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | AFF3 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | AFF3 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | AFF3 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | AFF3 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | AFF3 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | AFF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | AFF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | AFF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | AFF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | AFF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | AFF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | AFF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | AFF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | AFF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | AFF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | AFF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | AFF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | AFF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00001CF056 | AFF3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003677B2 | AFF3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D814 | AFF3 | 23313552 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000075CC78 | AFF3 | 23313552 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00006DE17B | AFF3 | 23313552 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00001012BC | AFF3 | 23313552 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000021202F | AFF3 | 23313552 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HNRNPL | AFF3 | 25348397 | N/A | physical interaction | ComPPI |
| CDK9 | AFF3 | 23455922 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| PIP4K2A | AFF3 | 25348397 | N/A | physical interaction | ComPPI |
| ERP29 | AFF3 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| TFRC | AFF3 | 24234451 30021884 | physical association | cross-linking study | IntAct |