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GENE：EIF2B1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EIF2B1
FullNmae eukaryotic translation initiation factor 2B subunit alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3257
EnsembleID ENSG00000111361
Uniprot Q14232

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EIF2B1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EIF2B1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EIF2B1 GO:0003743,GO:0003743,GO:0005085,GO:0005085,GO:0005515,GO:0005737,GO:0005829,GO:0005851,GO:0005851,GO:0005886,GO:0006413,GO:0006413,GO:0009408,GO:0009408,GO:0009749,GO:0014003,GO:0016020,GO:0042802,GO:0043434,GO:0050852

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EIF2B1 hsa:1967 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EIF2S1 EIF2B1 12601012 12667446 16246152 23850759 26192618 interaction type N/A ACSN
EIF2S2 EIF2B1 12601012 12667446 16246152 23850759 26192618 interaction type N/A ACSN
NDUFA7 EIF2B1 12601012 12667446 16246152 23850759 26192618 interaction type N/A ACSN
NDUFB4 EIF2B1 12601012 12667446 16246152 23850759 26192618 interaction type N/A ACSN
NDUFB5 EIF2B1 12601012 12667446 16246152 23850759 26192618 interaction type N/A ACSN
NDUFB6 EIF2B1 12601012 12667446 16246152 23850759 26192618 interaction type N/A ACSN
EIF2B1 EIF2B3 16246152 26192618 interaction type N/A ACSN
EIF2B1 EIF2B4 16246152 26192618 interaction type N/A ACSN
EIF2B1 EIF2B5 16246152 26192618 interaction type N/A ACSN
NDUFS1 EIF2B1 16246152 26192618 interaction type N/A ACSN
EIF2B1 BAX 16246152 26192618 interaction type N/A ACSN
EIF2S3 EIF2B1 16246152 26192618 interaction type N/A ACSN
NDUFA1 EIF2B1 26192618 association N/A ACSN
EIF2B1 ADRA2B 23180781 9235896 physical association pull down InnateDB
ADRB2 EIF2B1 23180781 9235896 physical association anti tag coimmunoprecipitation,pull down InnateDB
ADRA2A EIF2B1 23180781 9235896 physical association pull down InnateDB
ADRA2C EIF2B1 23180781 9235896 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 EIF2B1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 EIF2B1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 EIF2B1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 EIF2B1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 EIF2B1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 EIF2B1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 EIF2B1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 EIF2B1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000003ABC4 EIF2B1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000100748 EIF2B1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002152A8 EIF2B1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000427B68 EIF2B1 21572407 22927820 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB EIF2B1 21572407 22927820 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002233F4 EIF2B1 21572407 22927820 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001C308D EIF2B1 21572407 22927820 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000157026 EIF2B1 21572407 22927820 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000077AED EIF2B1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000202460 EIF2B1 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
STX12 EIF2B1 25348397 N/A physical interaction ComPPI
SGTB EIF2B1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF2B2 EIF2B1 10805739 14525934 24234451 25348397 29599245 9446619 physical association experimental interaction detection,molecular sieving,physical interaction,electron tomography,in vitro,inference by socio-affinity scoring ComPPI,HPRD,IntAct
FOXR2 EIF2B1 25348397 N/A physical interaction ComPPI
C1ORF50 EIF2B1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RD3 EIF2B1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RPL10 EIF2B1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
JUN EIF2B1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
CREBBP EIF2B1 14525934 15752756 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
ARHGDIA EIF2B1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DLD EIF2B1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NTRK1 EIF2B1 25348397 N/A physical interaction ComPPI
SERPINB13 EIF2B1 25348397 N/A physical interaction ComPPI
PDIA4 EIF2B1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HNRNPU EIF2B1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HNRNPL EIF2B1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CAD EIF2B1 25348397 N/A physical interaction ComPPI
GORASP2 EIF2B1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EIF2S1 EIF2B1 14525934 25348397 8887689 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
AP2A2 EIF2B1 25348397 N/A physical interaction ComPPI
XPO1 EIF2B1 25348397 N/A physical interaction ComPPI
AP2A1 EIF2B1 25348397 N/A physical interaction ComPPI
ADRB2 EIF2B1 14525934 24234451 25348397 9235896 colocalization,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,imaging technique,in vivo ComPPI,HPRD,IntAct
SYNCRIP EIF2B1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EGFR EIF2B1 25348397 N/A physical interaction ComPPI
STK11 EIF2B1 20368287 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
EIF2B1 EIF2S2 14525934 25348397 9446619 N/A experimental interaction detection,in vitro ComPPI,HPRD
EIF2B1 ADRA2A 14525934 25348397 9235896 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EIF2B1 ADRA2C 14525934 25348397 9235896 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EIF2B1 ADRA2B 14525934 25348397 9235896 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EIF2B1 EIF2B3 17353931 24234451 25348397 29599245 physical association anti bait coimmunoprecipitation,molecular sieving,physical interaction,electron tomography,inference by socio-affinity scoring ComPPI,IntAct
EIF2B1 EIF2B5 24234451 25348397 29599245 physical association molecular sieving,physical interaction,electron tomography,inference by socio-affinity scoring ComPPI,IntAct
EIF2B1 DCD 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF2B1 DCC 20434207 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF2B1 NTAQ1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EIF2B1 BZW2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EIF2B1 VTI1B 25348397 N/A physical interaction ComPPI
EIF2B1 CA14 25348397 N/A physical interaction ComPPI
EIF2B1 GPR183 25348397 N/A physical interaction ComPPI
EIF2B1 LUC7L 25348397 N/A physical interaction ComPPI
EIF2B1 P2RX4 25348397 N/A physical interaction ComPPI
EIF2B1 PTGER3 25348397 N/A physical interaction ComPPI
EIF2B1 NECTIN4 25348397 N/A physical interaction ComPPI
EIF2B1 HNRNPA1 25348397 N/A physical interaction ComPPI
EIF2B1 ARF1 25348397 N/A physical interaction ComPPI
EIF2B1 EIF2B4 24234451 25348397 29599245 physical association molecular sieving,physical interaction,electron tomography,inference by socio-affinity scoring ComPPI,IntAct
EIF2B1 LYPLA2 25348397 N/A physical interaction ComPPI
EIF2B1 MTAP 25348397 N/A physical interaction ComPPI
EIF2B1 SERPINB3 25348397 N/A physical interaction ComPPI
EIF2B1 TRMT6 25348397 N/A physical interaction ComPPI
EIF2B1 MPST 25348397 N/A physical interaction ComPPI
EIF2B1 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF2B1 NOP56 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF2B1 ZFC3H1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF2B1 EPM2A 25348397 N/A physical interaction ComPPI
EIF2B1 GYPB 25348397 N/A physical interaction ComPPI
EIF2B1 SIGLECL1 25348397 N/A physical interaction ComPPI
EIF2B1 CLEC3A 25348397 N/A physical interaction ComPPI
EIF2B1 BHLHA15 25348397 N/A physical interaction ComPPI
EIF2B1 SMDT1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EIF2B1 MCU 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EIF2B1 MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF2B1 TRIM59 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EIF2B1 TRIML2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EIF2B1 MED29 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EIF2B1 ATF5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ARL4D EIF2B1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MRPL4 EIF2B1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
EIF2B1 EIF2B1 10858531 14525934 24234451 25416956 physical association experimental interaction detection,two hybrid array,two hybrid prey pooling approach HPRD,IntAct
MYH9 EIF2B1 24234451 30021884 physical association cross-linking study IntAct
GSK3B EIF2B1 21798082 27898060 inhibition N/A OmniPath

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