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GENE：HLA-DRB5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HLA-DRB5
FullNmae major histocompatibility complex, class II, DR beta 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4953
EnsembleID ENSG00000198502
Uniprot Q30154

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HLA-DRB5 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HLA-DRB5 immunogenic 36579538 Through literature reviews, a total of 108 ICD-related genes were identified (Supplement Table S1). retulator signature

Go Annotation:

GeneSymbol Go id
HLA-DRB5 GO:0000139,GO:0002250,GO:0002503,GO:0005765,GO:0005765,GO:0005765,GO:0005886,GO:0012507,GO:0019886,GO:0023026,GO:0030658,GO:0030666,GO:0030669,GO:0031902,GO:0031902,GO:0032588,GO:0042605,GO:0042605,GO:0042613,GO:0042613,GO:0050778,GO:0050870,GO:0070062,GO:0098553

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HLA-DRB5 hsa:3127 path:hsa04145 Phagosome - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa04612 Antigen processing and presentation - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa04940 Type I diabetes mellitus - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa05140 Leishmaniasis - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa05152 Tuberculosis - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa05164 Influenza A - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa05310 Asthma - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa05322 Systemic lupus erythematosus - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa05330 Allograft rejection - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa05332 Graft-versus-host disease - Homo sapiens (human)
HLA-DRB5 hsa:3127 path:hsa05416 Viral myocarditis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SMARCA4 HLA-DRB5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CIITA HLA-DRB5 10886240 trascriptional regulation,stimulation inferred by curator TFlink
RFX5 HLA-DRB5 11258423 trascriptional regulation,stimulation inferred by curator TFlink
RFXANK HLA-DRB5 11258423 trascriptional regulation,stimulation inferred by curator TFlink
RFXAP HLA-DRB5 11258423 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 HLA-DRB5 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00003E226A HLA-DRB5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 HLA-DRB5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 HLA-DRB5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040FA88 HLA-DRB5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000003E1A9 HLA-DRB5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000020CEC2 HLA-DRB5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005DEC41 HLA-DRB5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 HLA-DRB5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004214BB HLA-DRB5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000204177 HLA-DRB5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000277201 HLA-DRB5 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
HSPA8 HLA-DRB5 25348397 N/A physical interaction ComPPI
STAT1 HLA-DRB5 25348397 N/A physical interaction ComPPI
HSP90AB1 HLA-DRB5 25348397 N/A physical interaction ComPPI
HSP90AA1 HLA-DRB5 25348397 N/A physical interaction ComPPI
HSPA5 HLA-DRB5 25348397 N/A physical interaction ComPPI
PKM HLA-DRB5 25348397 N/A physical interaction ComPPI
ATP1B1 HLA-DRB5 25348397 N/A physical interaction ComPPI
ANXA11 HLA-DRB5 25348397 N/A physical interaction ComPPI
CHEK1 HLA-DRB5 25348397 N/A physical interaction ComPPI
YWHAE HLA-DRB5 25348397 N/A physical interaction ComPPI
MS4A1 HLA-DRB5 25348397 N/A physical interaction ComPPI
HLA-A HLA-DRB5 25348397 N/A physical interaction ComPPI
HLA-DRB5 HLA-DRA 12244309 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
HLA-DRB5 HLA-DRB1 25348397 N/A physical interaction ComPPI

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