Gene Information gene info

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GENE：NEFM

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NEFM
FullNmae neurofilament medium chain
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7734
EnsembleID ENSG00000104722
Uniprot P07197

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NEFM immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NEFM GO:0005200,GO:0005515,GO:0005737,GO:0005882,GO:0005883,GO:0008017,GO:0030424,GO:0030424,GO:0033693,GO:0033693,GO:0045111,GO:0097418,GO:0099160

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NEFM hsa:4741 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
NEFM hsa:4741 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MYC NEFM 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF NEFM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 NEFM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFIC NEFM N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 NEFM 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
GOLGA2 NEFM 25348397 N/A physical interaction ComPPI
DES NEFM 25348397 N/A physical interaction ComPPI
VIM NEFM 24234451 25348397 27173435 association,physical association physical interaction,two hybrid array,tandem affinity purification,two hybrid prey pooling approach,inference by socio-affinity scoring ComPPI,IntAct
CCDC106 NEFM 25348397 N/A physical interaction ComPPI
KEAP1 NEFM 25348397 N/A physical interaction ComPPI
MCM2 NEFM 25348397 N/A physical interaction ComPPI
JUN NEFM 20195357 24234451 25348397 25609649 association,physical association anti bait coimmunoprecipitation,display technology ComPPI,IntAct
RB1 NEFM 20195357 24234451 25348397 physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
SMAD2 NEFM 20195357 24234451 25348397 physical association display technology,physical interaction ComPPI,IntAct
KSR2 NEFM 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
APOE NEFM 14525934 25348397 8620924 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NEFM MINK1 14525934 15032605 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
NEFM NEFH 14525934 25348397 2557834 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
NEFM STXBP1 12963086 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NEFM SQSTM1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NEFM DISC1 25348397 N/A physical interaction ComPPI
NEFM TNIK 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NEFM SIRT7 25348397 N/A physical interaction ComPPI
NEFM IQCB1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NEFM FOS 20195357 24234451 25348397 physical association display technology,physical interaction ComPPI,IntAct
NEFM PRKN 25348397 N/A physical interaction ComPPI
NEFM SART3 25348397 N/A physical interaction ComPPI
NEFM PSG9 25348397 N/A physical interaction ComPPI
NEFM CALD1 25348397 N/A physical interaction ComPPI
NEFM SS18 25348397 N/A physical interaction ComPPI
NEFM DNAJA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NEFM STOML2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NEFM RPRD1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NEFM GAN 25348397 N/A physical interaction ComPPI
NEFM INA 25348397 N/A physical interaction ComPPI
NEFM NES 25348397 N/A physical interaction ComPPI
NEFM SYNC 25348397 N/A physical interaction ComPPI
NEFM FBXW5 25348397 N/A physical interaction ComPPI
NEFM KIF7 25348397 N/A physical interaction ComPPI
NEFM GFAP 25348397 N/A physical interaction ComPPI
NEFM MLLT6 25348397 N/A physical interaction ComPPI
NEFM CAPN1 25348397 N/A physical interaction ComPPI
NEFM PLEC 25348397 N/A physical interaction ComPPI
NEFM IKBKG 25348397 N/A physical interaction ComPPI
NEFM CCHCR1 25348397 N/A physical interaction ComPPI
NEFM PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NEFM NR4A2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NEFM ETS1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NEFM MDM2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NEFM PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NEFL NEFM 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HSPD1 NEFM 24234451 30021884 physical association cross-linking study IntAct
NEFM STUB1 21219885 27898060 N/A N/A OmniPath
MAPK1 NEFM 27898060 9592082 inhibition N/A OmniPath

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