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GENE：SMC6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SMC6
FullNmae structural maintenance of chromosomes 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:20466
EnsembleID ENSG00000163029
Uniprot Q96SB8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SMC6 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SMC6 GO:0000217,GO:0000722,GO:0000724,GO:0000724,GO:0000775,GO:0000781,GO:0000781,GO:0000803,GO:0003684,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0006974,GO:0016605,GO:0016607,GO:0016925,GO:0030915,GO:0030915,GO:0030915,GO:0031625,GO:0032204,GO:0035061,GO:0035861,GO:0035861,GO:0044828,GO:0051984,GO:0090398,GO:0097431,GO:0140588

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR SMC6 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 SMC6 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SMC6 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SMC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SMC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SMC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SMC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SMC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SMC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SMC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000153377 SMC6 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
SMC6 RAD52 25361965 interaction type N/A PTMCode2
RAD52 SMC6 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BTF3 SMC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NSMCE2 SMC6 18086888 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP1 SMC6 24234451 25348397 26496610 29656893 association anti tag coimmunoprecipitation,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
STN1 SMC6 25348397 N/A physical interaction ComPPI
NTRK1 SMC6 25348397 N/A physical interaction ComPPI
MYC SMC6 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
MKI67 SMC6 25348397 N/A physical interaction ComPPI
RAD18 SMC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SCARB2 SMC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MDC1 SMC6 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
NCKIPSD SMC6 25348397 N/A physical interaction ComPPI
PJA1 SMC6 25348397 N/A physical interaction ComPPI
H3C1 SMC6 25348397 N/A physical interaction ComPPI
TTC19 SMC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TUFT1 SMC6 25348397 N/A physical interaction ComPPI
IGHMBP2 SMC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KIF1B SMC6 25348397 N/A physical interaction ComPPI
BRCA1 SMC6 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
PRDX3 SMC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSF1 SMC6 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
HPS5 SMC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DGCR8 SMC6 25348397 N/A physical interaction ComPPI
ASCC1 SMC6 25348397 N/A physical interaction ComPPI
HEATR1 SMC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KLC2 SMC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELP3 SMC6 25348397 N/A physical interaction ComPPI
IFT88 SMC6 25348397 N/A physical interaction ComPPI
ALK SMC6 25348397 N/A physical interaction ComPPI
EID3 SMC6 18086888 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CCDC174 SMC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPB11 SMC6 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
IFT27 SMC6 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
LAMA2 SMC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HEXB SMC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TTC3 SMC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NSMCE3 SMC6 18086888 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMC5 SMC6 15601840 18086888 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
SMC6 NSMCE1 14701739 18086888 24234451 25348397 26186194 26344197 26496610 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,molecular sieving,physical interaction ComPPI,IntAct,OmniPath
SMC6 NSMCE4A 18086888 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMC6 ZNF597 25348397 N/A physical interaction ComPPI
SMC6 ZFP36L2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMC6 CEPT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMC6 GPN3 25348397 N/A physical interaction ComPPI
SMC6 PLXNA3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMC6 SLF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMC6 TMEM165 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMC6 TMEM126A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMC6 SLF1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMC6 MAK16 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMC6 PWWP3A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMC6 ESCO1 25348397 N/A physical interaction ComPPI
SMC6 B3GLCT 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMC6 ZBED6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMC6 TSPYL6 25348397 N/A physical interaction ComPPI
SMARCA5 SMC6 24234451 30021884 physical association cross-linking study IntAct
DHRS2 SMC6 24234451 30021884 physical association cross-linking study IntAct
HNRNPD SMC6 24234451 30021884 physical association cross-linking study IntAct
NSMCE2 SMC6 15738391 16055714 18086888 22751501 26344197 26496610 27898060 stimulant N/A OmniPath

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