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GENE：TRAF3IP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TRAF3IP2
FullNmae TRAF3 interacting protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1343
EnsembleID ENSG00000056972
Uniprot O43734

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TRAF3IP2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TRAF3IP2 GO:0001768,GO:0001782,GO:0001783,GO:0001822,GO:0002230,GO:0002269,GO:0002334,GO:0002344,GO:0002447,GO:0005102,GO:0005515,GO:0005575,GO:0005634,GO:0006606,GO:0006954,GO:0006959,GO:0007507,GO:0009410,GO:0023019,GO:0023035,GO:0030217,GO:0031234,GO:0031410,GO:0033209,GO:0035556,GO:0038173,GO:0042092,GO:0042119,GO:0043123,GO:0043123,GO:0043588,GO:0048255,GO:0048535,GO:0048536,GO:0061630,GO:0070254,GO:0070534,GO:0072538,GO:0097400,GO:0110012,GO:1990959

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TRAF3IP2 hsa:10758 path:hsa04218 Cellular senescence - Homo sapiens (human)
TRAF3IP2 hsa:10758 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP3K7 TRAF3IP2 12089335 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF1 TRAF3IP2 12089335 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF1 TRAF3IP2 12759449 23180781 physical association electrophoretic mobility supershift assay InnateDB
CEBPB TRAF3IP2 12759449 23180781 physical association electrophoretic mobility supershift assay InnateDB
IL17RA TRAF3IP2 17035243 17277779 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF3IP2 IL17RA 17277779 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF3IP2 MAP3K7 17277779 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF3IP2 TRAF3 15485634 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF3IP2 CD40 15485634 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF3IP2 TRAF2 15485634 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF3IP2 TNFRSF13C 15485634 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF13C TRAF3IP2 15485634 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF6 TRAF3IP2 19825828 23180781 ubiquitination reaction enzymatic study InnateDB

Source Target Pmid Interactiontype Methods Database
TRAF3IP2 CHUK 20005715 interaction type N/A PSP
TRAF3IP2 MAP3K7 20005715 interaction type N/A PSP,SignaLink
TRAF3IP2 TRAF6 20005715 interaction type N/A PSP,SignaLink

Source Target Pmid Interactiontype Methods Database
AR TRAF3IP2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 TRAF3IP2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 TRAF3IP2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TRAF3IP2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 TRAF3IP2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 TRAF3IP2 18922183 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 TRAF3IP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TRAF3IP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TRAF3IP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TRAF3IP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TRAF3IP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TRAF3IP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TRAF3IP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TRAF3IP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TRAF3IP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 TRAF3IP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 TRAF3IP2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000C5BAA TRAF3IP2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000215483 TRAF3IP2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075B538 TRAF3IP2 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 TRAF3IP2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 TRAF3IP2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000136174 TRAF3IP2 20371350 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004B4B85 TRAF3IP2 20371350 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A TRAF3IP2 20371350 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000BA274 TRAF3IP2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075C1E1 TRAF3IP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 TRAF3IP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032AE90 TRAF3IP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC TRAF3IP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 TRAF3IP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 TRAF3IP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE TRAF3IP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A TRAF3IP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D TRAF3IP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E TRAF3IP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 TRAF3IP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002D2333 TRAF3IP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 TRAF3IP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 TRAF3IP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 TRAF3IP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 TRAF3IP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 TRAF3IP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C TRAF3IP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 TRAF3IP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 TRAF3IP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 TRAF3IP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 TRAF3IP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 TRAF3IP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F TRAF3IP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA TRAF3IP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 TRAF3IP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 TRAF3IP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 TRAF3IP2 25416803 26376209 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
TRAF6 TRAF3IP2 25361965 interaction type N/A PTMCode2
TRAF3IP2 TRAF6 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GOLGA2 TRAF3IP2 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
STK16 TRAF3IP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FHL3 TRAF3IP2 25348397 N/A physical interaction ComPPI
TRAF6 TRAF3IP2 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
QPRT TRAF3IP2 25348397 N/A physical interaction ComPPI
MRPL28 TRAF3IP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MDFI TRAF3IP2 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SYK TRAF3IP2 25348397 N/A physical interaction ComPPI
UBC TRAF3IP2 25348397 N/A physical interaction ComPPI
HSP90AA1 TRAF3IP2 24120361 25024377 25348397 27898060 N/A physical interaction ComPPI,OmniPath
IRF3 TRAF3IP2 25348397 N/A physical interaction ComPPI
IKBKB TRAF3IP2 25348397 N/A physical interaction,in vivo ComPPI
TRAF3 TRAF3IP2 25348397 N/A physical interaction,in vivo ComPPI
TRIP6 TRAF3IP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TRAF1 TRAF3IP2 25348397 N/A in vitro,in vivo ComPPI
TRAF2 TRAF3IP2 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SRSF1 TRAF3IP2 21822258 23772036 24234451 25348397 27898060 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
TRAF5 TRAF3IP2 21822258 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,IntAct
HSPA4 TRAF3IP2 25348397 N/A physical interaction ComPPI
CHUK TRAF3IP2 25348397 N/A physical interaction,in vivo ComPPI
MAP3K7 TRAF3IP2 25348397 N/A physical interaction,in vivo ComPPI
TRAF3IP2 CD40 25348397 N/A physical interaction,in vivo ComPPI
TRAF3IP2 IKBKG 10962024 10962033 12943667 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TRAF3IP2 IL17RA 17035243 17277779 22045852 24120361 25202827 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TRAF3IP2 TNFRSF13C 25348397 N/A physical interaction ComPPI
TRAF3IP2 TBK1 25348397 N/A physical interaction ComPPI
TRAF3IP2 IKBKE 22851696 23066157 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TRAF3IP2 UBE2V1 25348397 N/A physical interaction ComPPI
TRAF3IP2 ELAVL1 25348397 N/A physical interaction ComPPI
TRAF3IP2 RIMBP3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TRAF3IP2 HSP90AA2P 25348397 N/A physical interaction ComPPI
TRAF3IP2 IL17RB 25348397 N/A physical interaction ComPPI
TRAF3IP2 IL17RC 25348397 N/A physical interaction ComPPI
TRAF3IP2 MMGT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAF3IP2 HSD17B10 25348397 N/A physical interaction ComPPI
TRAF3IP2 INVS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
IL17A TRAF3IP2 25348397 N/A physical interaction ComPPI
MAP3K7 TRAF3IP2 12089335 17277779 27898060 N/A N/A OmniPath
TRAF3IP2 MAP3K7 12089335 17277779 27898060 N/A N/A OmniPath
TRAF3IP2 TRAF2 15485634 16189514 21822258 27898060 N/A N/A OmniPath
TRAF2 TRAF3IP2 15485634 16189514 21822258 27898060 N/A N/A OmniPath
TRAF3IP2 TRAF6 12459498 17277779 19825828 21516116 21822258 22851696 23737552 25202827 25416956 27898060 N/A N/A OmniPath
TRAF3IP2 CD40 12089335 15485634 24120361 27898060 N/A N/A OmniPath
TRAF3IP2 TRAF3 12089335 15485634 24120361 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS0000032F49 TRAF3IP2 10903453 27087310 direct interaction,inhibition N/A NPInter

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