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GENE：POLE2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol POLE2
FullNmae DNA polymerase epsilon 2, accessory subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9178
EnsembleID ENSG00000100479
Uniprot P56282

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
POLE2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
POLE2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
POLE2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
POLE2 GO:0003677,GO:0003887,GO:0005515,GO:0005654,GO:0005654,GO:0006260,GO:0006261,GO:0006261,GO:0006281,GO:0008622,GO:0008622,GO:0008622,GO:0016604,GO:0042276,GO:0043231

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
POLE2 hsa:5427 path:hsa03030 DNA replication - Homo sapiens (human)
POLE2 hsa:5427 path:hsa03410 Base excision repair - Homo sapiens (human)
POLE2 hsa:5427 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 POLE2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 POLE2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 POLE2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 POLE2 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C POLE2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA POLE2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF POLE2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 POLE2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A POLE2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 POLE2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 POLE2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFIC POLE2 11433027 trascriptional regulation,stimulation inferred by curator TFlink
SP1 POLE2 11433027 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 POLE2 11433027 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 POLE2 N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F2 POLE2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 POLE2 20304954 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
POLE2 GINS1 25361965 interaction type N/A PTMCode2
GINS1 POLE2 25361965 interaction type N/A PTMCode2
POLE2 POLE 25361965 interaction type N/A PTMCode2
POLE POLE2 25361965 interaction type N/A PTMCode2
POLE2 POLE3 25361965 interaction type N/A PTMCode2
POLE3 POLE2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAPRE1 POLE2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TFAP4 POLE2 25348397 N/A physical interaction ComPPI
ZBED1 POLE2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SAP18 POLE2 11872158 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
SORBS3 POLE2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
POLE4 POLE2 10801849 14525934 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
POLE3 POLE2 10801849 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TLE1 POLE2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
REL POLE2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PEX19 POLE2 25348397 N/A physical interaction ComPPI
POLE POLE2 10801849 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RPL28 POLE2 25348397 N/A physical interaction ComPPI
EEF1A1 POLE2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PKM POLE2 25348397 N/A physical interaction ComPPI
DNAJC7 POLE2 25348397 N/A physical interaction ComPPI
UBQLN2 POLE2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TENT5A POLE2 25348397 N/A physical interaction ComPPI
EXOSC4 POLE2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CD79B POLE2 25348397 N/A physical interaction ComPPI
AGFG1 POLE2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TRIM27 POLE2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RAD17 POLE2 25348397 N/A physical interaction ComPPI
TRIP13 POLE2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPINT2 POLE2 25348397 N/A physical interaction ComPPI
ZBTB21 POLE2 25348397 N/A physical interaction ComPPI
POLE2 KAT5 14525934 16169070 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,two hybrid ComPPI,HPRD,IntAct
POLE2 ERG28 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
POLE2 EEF1A1P5 25348397 N/A physical interaction ComPPI
POLE2 POLD4 25348397 N/A physical interaction ComPPI
POLE2 TBX15 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
POLE2 NXF1 25348397 N/A physical interaction ComPPI
POLE2 KLK11 25348397 N/A physical interaction ComPPI
POLE2 KLK5 25348397 N/A physical interaction ComPPI
POLE2 LRRC46 25348397 N/A physical interaction ComPPI
POLE2 PCGF1 25348397 N/A physical interaction ComPPI
POLE2 ARL4C 25348397 N/A physical interaction ComPPI
POLE2 C6ORF141 25348397 N/A physical interaction ComPPI
POLE2 BMERB1 25348397 N/A physical interaction ComPPI
POLE2 LGALS7 25348397 N/A physical interaction ComPPI
POLE2 SNX21 25348397 N/A physical interaction ComPPI
POLE2 CYP4F12 25348397 N/A physical interaction ComPPI
POLE2 ZUP1 25348397 N/A physical interaction ComPPI

Visualization










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