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GENE：GCC2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GCC2
FullNmae GRIP and coiled-coil domain containing 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:23218
EnsembleID ENSG00000135968
Uniprot Q8IWJ2

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GCC2 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
GCC2 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
GCC2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GCC2 GO:0005515,GO:0005654,GO:0005794,GO:0005794,GO:0005802,GO:0005829,GO:0006622,GO:0016020,GO:0031023,GO:0031267,GO:0034067,GO:0034453,GO:0034499,GO:0034499,GO:0042147,GO:0042802,GO:0070861,GO:0071955,GO:0090161

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GCC2 hsa:9648 path:hsa05132 Salmonella infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR GCC2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 GCC2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 GCC2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 GCC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GCC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GCC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GCC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 GCC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 GCC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 GCC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 GCC2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005606AA GCC2 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 GCC2 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002CF3F0 GCC2 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ARL1 GCC2 25361965 interaction type N/A PTMCode2
GCC2 ARL1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
WASHC3 GCC2 25348397 N/A physical interaction ComPPI
PKD2 GCC2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
KIFAP3 GCC2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HNRNPL GCC2 25348397 N/A physical interaction ComPPI
RAB6A GCC2 18243103 24234451 25348397 27898060 N/A affinity chromatography technology,isothermal titration calorimetry,x-ray crystallography ComPPI,IntAct,OmniPath
EXOC3 GCC2 25348397 N/A physical interaction ComPPI
PSMC5 GCC2 25348397 N/A physical interaction ComPPI
RAD23A GCC2 25348397 N/A physical interaction ComPPI
ADCYAP1 GCC2 25348397 N/A physical interaction ComPPI
TUBA1A GCC2 24234451 25348397 27291054 association pull down ComPPI,IntAct
PMF1 GCC2 25348397 N/A physical interaction ComPPI
SRPK2 GCC2 25348397 N/A physical interaction ComPPI
MRE11 GCC2 25348397 N/A physical interaction ComPPI
ESR2 GCC2 21182203 24234451 25348397 association cosedimentation through density gradient ComPPI,IntAct
SYNC GCC2 25348397 N/A physical interaction ComPPI
SNU13 GCC2 25348397 N/A physical interaction ComPPI
TGOLN2 GCC2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MLLT6 GCC2 25348397 N/A physical interaction ComPPI
ZRANB1 GCC2 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARL1 GCC2 18243103 24234451 25348397 N/A affinity chromatography technology,physical interaction ComPPI,IntAct
BET1 GCC2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CLASP1 GCC2 25348397 N/A physical interaction ComPPI
SPC25 GCC2 25348397 N/A physical interaction ComPPI
TCP10L GCC2 25348397 N/A physical interaction ComPPI
GCC2 DHX16 25348397 N/A physical interaction ComPPI
GCC2 TTC4 25348397 N/A physical interaction ComPPI
GCC2 HERC2 25348397 N/A physical interaction ComPPI
GCC2 HERC2P3 25348397 N/A physical interaction ComPPI
GCC2 SSC5D 25348397 N/A physical interaction ComPPI
GCC2 CCDC136 25348397 N/A physical interaction ComPPI
GCC2 CCDC107 25348397 N/A physical interaction ComPPI
GCC2 AIMP1 25348397 N/A physical interaction ComPPI
GCC2 GCC2 14525934 15654769 18243103 24234451 physical association cross-linking study,experimental interaction detection,molecular sieving HPRD,IntAct
STK38L GCC2 24234451 30108113 association proximity-dependent biotin identification IntAct
RPN1 GCC2 24234451 30021884 physical association cross-linking study IntAct

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