GeneInfo:
GeneAttribute |
GeneDescription |
GeneSymbol |
MCUB |
FullNmae |
mitochondrial calcium uniporter dominant negative subunit beta |
LocusType |
gene with protein product |
Status |
Approved |
HGNC_id |
HGNC:26076 |
EnsembleID |
ENSG00000005059 |
Uniprot |
Q9NWR8 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol |
CellDeathType |
PMID |
Description |
GeneType |
MCUB |
mpt |
32299299 |
MCUb overexpressing mice demonstrated inhibited mitochondrial Ca2+ uptake in cardiomyocytes and partial protection from ischemia-reperfusion injury by reducing mitochondrial permeability transition pore opening. |
retulator signature |
MCUB |
immunogenic |
38538696 |
The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) |
retulator signature |
Go Annotation:
GeneSymbol |
Go id |
MCUB |
GO:0005654,GO:0005739,GO:0005739,GO:0005743,GO:0005743,GO:0005743,GO:0006851,GO:0016020,GO:0019855,GO:0019855,GO:0034704,GO:0036444,GO:0036444,GO:0043231,GO:0051560,GO:0051560,GO:0051560,GO:1990246,GO:1990246,GO:1990246 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source |
Target |
Pmid |
Interactiontype |
Methods |
Database |
ETS1 |
MCUB |
18971253
20019798
|
trascriptional regulation,stimulation |
inferred by curator,chromatin immunoprecipitation assay |
TFlink |
TFAP2C |
MCUB |
20629094
|
trascriptional regulation,stimulation |
chromatin immunoprecipitation assay |
TFlink |
FOXP3 |
MCUB |
20554955
|
trascriptional regulation,stimulation |
chromatin immunoprecipitation array |
TFlink |
SMARCA4 |
MCUB |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
CTCF |
MCUB |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
E2F4 |
MCUB |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
FOXA1 |
MCUB |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
FOXP1 |
MCUB |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
FOS |
MCUB |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
GATA2 |
MCUB |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
HNF4A |
MCUB |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
SPI1 |
MCUB |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
TRIM28 |
MCUB |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
TAL1 |
MCUB |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
Source |
Target |
Pmid |
Interactiontype |
Methods |
Database |
URS000003ABC4 |
MCUB |
19088304
25416803
|
mrna cleavage,inhibition |
array technology |
TarBase |
URS000005481D |
MCUB |
23622248
25416803
|
mrna cleavage,inhibition |
clash |
TarBase |
Source |
Target |
Pmid |
Interactiontype |
Methods |
Database |
SETDB1 |
MCUB |
25348397
|
N/A |
physical interaction |
ComPPI |
ZBTB16 |
MCUB |
14525934
16169070
24234451
25348397
|
physical association |
two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid |
ComPPI,HPRD,IntAct |
GNAI2 |
MCUB |
25348397
|
N/A |
physical interaction |
ComPPI |
ASPH |
MCUB |
25348397
|
N/A |
physical interaction |
ComPPI |
FAF2 |
MCUB |
25348397
|
N/A |
physical interaction |
ComPPI |
SLC25A10 |
MCUB |
25348397
|
N/A |
physical interaction |
ComPPI |
MRPL12 |
MCUB |
25348397
|
N/A |
physical interaction |
ComPPI |
Visualization